Title: Electrospun porous La–Sr–Co–Ni–O nanofibers for highly sensitive non-enzymatic glucose detection

Abstract

Glucose biosensors are widely used for clinical, industrial, and environmental applications. Nonenzymatic electrochemical glucose biosensors based on metal oxides with a perovskite structure have exhibited high sensitivity, excellent stability, and cost efficiency. In this work, porous La–Sr–Co–Ni–O (LSCNO) nanofibers, with an ABO₃-type perovskite structure, were prepared through optimizing the A-site and B-site elements by electrospinning, followed with calcination at 700 °C for 5 h. Characterized by scanning and transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, fabricated nanofibers were confirmed to be porous and nanosized polycrystalline grains with high crystallinity. A novel La_0.75Sr_0.25Co_0.5Ni_0.5O₃-based nonenzymatic electrochemical biosensor was developed, which is sensitive to glucose because of an electrochemically catalytic mechanism, a mediated electron transfer involving Ni(II)/Ni(III) or Co(II)/Co(III), accompanying with gluconic acid complexation. The glucose biosensor presented a linear response in the range of 0.1–1.0 mM with a calibration sensitivity of 924 ± 28 μA mM^–1, a proportion of the variance of 0.9926, and a lower limit of detection of 0.083 mM, respectively, demonstrating an outstanding analytical performance. The biosensor showed no response to the most widely used anionic surfactant, sodium dodecyl sulfate, and low sensitivity to other biomolecules, such as fructose, lactose, galactose, mannose, dopamine, and ascorbic acid. Amore » urine sample was tested by this novel nonenzymatic electrochemical biosensor by standard addition method, suggesting a potential application for clinical test.« less

Authors:

Pelucarte, Kasci D. ^[1]; Hatchell, Tashi A. ^[2]; George, Gibin  ^[1];

• Search DOE PAGES for author "George, Gibin"
• Search DOE PAGES for ORCID "0000-0002-4236-4860"

Ede, Sivasankara Rao ^[2]; Adhikari, Menuka ^[2]; Lin, Yulin ^[3]; Wen, Jianguo  ^[3];

• Search DOE PAGES for author "Wen, Jianguo"
• Search DOE PAGES for ORCID "0000-0002-3755-0044"

Luo, Zhiping  ^[2];

• Search DOE PAGES for author "Luo, Zhiping"
• Search DOE PAGES for ORCID "0000-0002-8264-6424"

Han, Shubo  ^[2]

• Search DOE PAGES for author "Han, Shubo"
• Search DOE PAGES for ORCID "0000-0002-0216-5111"

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+ Show Author Affiliations

1. Fayetteville State Univ., NC (United States); Campbell Univ., Lillington, NC (United States); GG-SCMS School of Engineering and Technology, Kerala (India)
2. Fayetteville State Univ., NC (United States)
3. Argonne National Lab. (ANL), Lemont, IL (United States)

Publication Date:

Tue Jan 11 00:00:00 EST 2022

Research Org.:

Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:

National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

OSTI Identifier:

1846278

Grant/Contract Number:  

AC02-06CH11357

Resource Type:

Accepted Manuscript

Journal Name:

Materials Advances

Additional Journal Information:

Journal Volume: 3; Journal Issue: 4; Journal ID: ISSN 2633-5409

Publisher:

Royal Society of Chemistry

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE