A Third Generation Potentially Bifunctional Trithiol Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (119Sb) from Its Sn Target

Olson, Aeli P.; Ma, Li; Feng, Yutian; Khosroshahi, Firouzeh Najafi; Kelley, Steven P.; Aluicio-Sarduy, Eduardo; Barnhart, Todd E.; Hennkens, Heather M.; Ellison, Paul A.; Jurisson, Silvia S.; Engle, Jonathan W.

doi:10.1021/acs.inorgchem.1c01690

Title: A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target

Journal Article · 04 October 2021 · Inorganic Chemistry

DOI: https://doi.org/10.1021/acs.inorgchem.1c01690 · OSTI ID:1846100

Olson, Aeli P. ^[1]; Ma, Li ^[2]; Feng, Yutian ^[3]; Khosroshahi, Firouzeh Najafi ^[2];

^[2]; Aluicio-Sarduy, Eduardo ^[4]; Barnhart, Todd E. ^[4];

^[5];

^[4];

^[2];

^[4]

Univ. of Wisconsin, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison
Univ. of Missouri, Columbia, MO (United States)
Duke Univ. Medical Center, Durham, NC (United States)
Univ. of Wisconsin, Madison, WI (United States)
Univ. of Missouri, Columbia, MO (United States); Univ. of Missouri Research Reactor (MURR), Columbia, MO (United States)

The therapeutic potential of the Meitner-Auger- and conversion-electron emitting radionuclide ¹¹⁹Sb remains unexplored because of the difficulty of incorporating it into biologically targeted compounds. To address this challenge, we report the development of ¹¹⁹Sb production from electroplated tin cyclotron targets and its complexation by a novel trithiol chelate. Here, the chelation reaction occurs in harsh solvent conditions even in the presence of large quantities of tin, which are necessary for production on small, low energy (16 MeV) cyclotrons. The ¹¹⁹Sb-trithiol complex has high stability and can be purified by HPLC. The third generation trithiol chelate and the analogous stable ^natSb-trithiol compound were synthesized and characterized, including by single crystal X-ray diffraction analyses.

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Research Organization:: Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0010283; SC0020159

OSTI ID:: 1846100

Journal Information:: Inorganic Chemistry, Journal Name: Inorganic Chemistry Journal Issue: 20 Vol. 60; ISSN 0020-1669

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Title: A Third Generation Potentially Bifunctional Trithiol Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (119Sb) from Its Sn Target

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Title: A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target