Biocompatible surface functionalization architecture for a diamond quantum sensor

Xie, Mouzhe; Yu, Xiaofei; Rodgers, Lila V. H.; Xu, Daohong; Chi-Durán, Ignacio; Toros, Adrien; Quack, Niels; de Leon, Nathalie P.; Maurer, Peter C.

doi:10.1073/pnas.2114186119

Title: Biocompatible surface functionalization architecture for a diamond quantum sensor

Journal Article · 22 February 2022 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.2114186119 · OSTI ID:1846056

^[1]; Yu, Xiaofei ^[2];

^[3]; Xu, Daohong ^[2];

^[4]; Toros, Adrien ^[5];

^[6]; de Leon, Nathalie P. ^[3];

^[1]

Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637
Department of Physics, The University of Chicago, Chicago, IL 60637
Department of Electrical and Computer Engineering, Princeton University, Princeton, NJ 08544
Department of Chemistry, The University of Chicago, Chicago, IL 60637
Center of MicroNanoTechnology, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland
Institute of Microengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland

Significance Diamond-based quantum sensing enables nanoscale measurements of biological systems with unprecedented sensitivity. Potential applications of this emerging technology range from the investigation of fundamental biological processes to the development of next-generation medical diagnostics devices. One of the main challenges faced by bioquantum sensing is the need to interface quantum sensors with biological target systems. Specifically, such an interface needs to maintain the highly fragile quantum states of our sensor and at the same time be able to fish intact biomolecules out of solution and immobilize them on our quantum sensor surface. Our work overcomes these challenges by combining tools from quantum engineering, single-molecule biophysics, and material processing.

View Journal Article

Cite

Export

Save

Research Organization:: University of Chicago, IL (United States)

Sponsoring Organization:: National Science Foundation (NSF); Swiss National Science Foundation (SNSF); US Department of Defense (USDOD); USDOE

OSTI ID:: 1846056

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 8 Vol. 119; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

References (40)

Nitrilotriacetic Acid Functionalized Graft Copolymers: A Polymeric Interface for Selective and Reversible Binding of Histidine-Tagged Proteins Zhen, G.; Falconnet, D.; Kuennemann, E. Advanced Functional Materials, Vol. 16, Issue 2 https://doi.org/10.1002/adfm.200500232	journal	January 2006
Dissolution Behaviors and Applications of Silicon Oxides and Nitrides in Transient Electronics Kang, Seung-Kyun; Hwang, Suk-Won; Cheng, Huanyu Advanced Functional Materials, Vol. 24, Issue 28 https://doi.org/10.1002/adfm.201304293	journal	April 2014
NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors Meyer, Bernd; Peters, Thomas Angewandte Chemie International Edition, Vol. 42, Issue 8 https://doi.org/10.1002/anie.200390233	journal	February 2003
In-Cell NMR and EPR Spectroscopy of Biomacromolecules Hänsel, Robert; Luh, Laura M.; Corbeski, Ivan Angewandte Chemie International Edition, Vol. 53, Issue 39 https://doi.org/10.1002/anie.201311320	journal	July 2014
Chemical Functionalization of Nanodiamonds: Opportunities and Challenges Ahead Reina, Giacomo; Zhao, Li; Bianco, Alberto Angewandte Chemie International Edition, Vol. 58, Issue 50 https://doi.org/10.1002/anie.201905997	journal	December 2019
Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides Dommerholt, Jan; Rutjes, Floris P. J. T.; van Delft, Floris L. Topics in Current Chemistry, Vol. 374, Issue 2 https://doi.org/10.1007/s41061-016-0016-4	journal	March 2016
Ratiometric measurement and identification of single diffusing molecules Dahan, Maxime; Deniz, Ashok A.; Ha, Taekjip Chemical Physics, Vol. 247, Issue 1 https://doi.org/10.1016/S0301-0104(99)00132-9	journal	August 1999
ESCORTing proteins directly from whole cell-lysate for single-molecule studies Srinivasan, Shwetha; Hazra, Jagadish P.; Singaraju, Gayathri S. Analytical Biochemistry, Vol. 535 https://doi.org/10.1016/j.ab.2017.07.022	journal	October 2017
Systematic comparison of various oxidation treatments on diamond surface Li, Chenxi; Zhang, Xiang; Oliveira, Eliezer F. Carbon, Vol. 182 https://doi.org/10.1016/j.carbon.2021.06.050	journal	September 2021
The future of NMR-based metabolomics Markley, John L.; Brüschweiler, Rafael; Edison, Arthur S. Current Opinion in Biotechnology, Vol. 43 https://doi.org/10.1016/j.copbio.2016.08.001	journal	February 2017
Cleaning diamond surfaces using boiling acid treatment in a standard laboratory chemical hood Brown, Kimberly Jean; Chartier, Elizabeth; Sweet, Ellen M. Journal of Chemical Health & Safety, Vol. 26, Issue 6 https://doi.org/10.1016/j.jchas.2019.06.001	journal	November 2019
Looking into Living Cell Systems: Planar Waveguide Microfluidic NMR Detector for in Vitro Metabolomics of Tumor Spheroids Kalfe, Ayten; Telfah, Ahmad; Lambert, Jörg Analytical Chemistry, Vol. 87, Issue 14 https://doi.org/10.1021/acs.analchem.5b01603	journal	June 2015
Nitrogen-Terminated Diamond Surface for Nanoscale NMR by Shallow Nitrogen-Vacancy Centers Kawai, Sora; Yamano, Hayate; Sonoda, Takahiro The Journal of Physical Chemistry C, Vol. 123, Issue 6 https://doi.org/10.1021/acs.jpcc.8b11274	journal	January 2019
Impact of Surface Functionalization on the Quantum Coherence of Nitrogen-Vacancy Centers in Nanodiamonds Ryan, Robert G.; Stacey, Alastair; O’Donnell, Kane M. ACS Applied Materials & Interfaces, Vol. 10, Issue 15 https://doi.org/10.1021/acsami.7b19238	journal	December 2017
Engineered Micro- and Nanoscale Diamonds as Mobile Probes for High-Resolution Sensing in Fluid Andrich, Paolo; Alemán, Benjamín J.; Lee, Jonathan C. Nano Letters, Vol. 14, Issue 9 https://doi.org/10.1021/nl501208s	journal	August 2014
Proper Surface Termination for Luminescent Near-Surface NV Centers in Diamond Kaviani, Moloud; Deák, Peter; Aradi, Bálint Nano Letters, Vol. 14, Issue 8 https://doi.org/10.1021/nl501927y	journal	July 2014
High-resolution magnetic resonance spectroscopy using a solid-state spin sensor Glenn, David R.; Bucher, Dominik B.; Lee, Junghyun Nature, Vol. 555, Issue 7696 https://doi.org/10.1038/nature25781	journal	March 2018
Single-cell magnetic imaging using a quantum diamond microscope Glenn, David R.; Lee, Kyungheon; Park, Hongkun Nature Methods, Vol. 12, Issue 8 https://doi.org/10.1038/nmeth.3449	journal	June 2015
High-sensitivity diamond magnetometer with nanoscale resolution Taylor, J. M.; Cappellaro, P.; Childress, L. Nature Physics, Vol. 4, Issue 10 https://doi.org/10.1038/nphys1075	journal	September 2008
Thiol-based, site-specific and covalent immobilization of biomolecules for single-molecule experiments Zimmermann, Julia L.; Nicolaus, Thomas; Neuert, Gregor Nature Protocols, Vol. 5, Issue 6 https://doi.org/10.1038/nprot.2010.49	journal	May 2010
Single-molecule pull-down for studying protein interactions Jain, Ankur; Liu, Ruijie; Xiang, Yang K. Nature Protocols, Vol. 7, Issue 3 https://doi.org/10.1038/nprot.2011.452	journal	February 2012
In situ observation of protein phosphorylation by high-resolution NMR spectroscopy Selenko, Philipp; Frueh, Dominique P.; Elsaesser, Simon J. Nature Structural & Molecular Biology, Vol. 15, Issue 3 https://doi.org/10.1038/nsmb.1395	journal	February 2008
Atomic-scale imaging of a 27-nuclear-spin cluster using a quantum sensor Abobeih, M. H.; Randall, J.; Bradley, C. E. Nature, Vol. 576, Issue 7787 https://doi.org/10.1038/s41586-019-1834-7	journal	December 2019
Single-DNA electron spin resonance spectroscopy in aqueous solutions Shi, Fazhan; Kong, Fei; Zhao, Pengju Nature Methods, Vol. 15, Issue 9 https://doi.org/10.1038/s41592-018-0084-1	journal	August 2018
Diamond surface functionalization: from gemstone to photoelectrochemical applications Raymakers, Jorne; Haenen, Ken; Maes, Wouter Journal of Materials Chemistry C, Vol. 7, Issue 33 https://doi.org/10.1039/C9TC03381E	journal	January 2019
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells Shalek, A. K.; Robinson, J. T.; Karp, E. S. Proceedings of the National Academy of Sciences, Vol. 107, Issue 5, p. 1870-1875 https://doi.org/10.1073/pnas.0909350107	journal	January 2010
Surface NMR using quantum sensors in diamond Liu, Kristina S.; Henning, Alex; Heindl, Markus W. Proceedings of the National Academy of Sciences, Vol. 119, Issue 5 https://doi.org/10.1073/pnas.2111607119	journal	January 2022
Diamond for bio-sensor applications Nebel, Christoph E.; Rezek, Bohuslav; Shin, Dongchan Journal of Physics D: Applied Physics, Vol. 40, Issue 20 https://doi.org/10.1088/0022-3727/40/20/S21	journal	October 2007
Unambiguous nuclear spin detection using an engineered quantum sensing sequence Shu, Zijun; Zhang, Zhendong; Cao, Qingyun Physical Review A, Vol. 96, Issue 5 https://doi.org/10.1103/PhysRevA.96.051402	journal	November 2017
Chemical control of the charge state of nitrogen-vacancy centers in diamond Hauf, M. V.; Grotz, B.; Naydenov, B. Physical Review B, Vol. 83, Issue 8 https://doi.org/10.1103/PhysRevB.83.081304	journal	February 2011
NMR technique for determining the depth of shallow nitrogen-vacancy centers in diamond Pham, Linh M.; DeVience, Stephen J.; Casola, Francesco Physical Review B, Vol. 93, Issue 4 https://doi.org/10.1103/PhysRevB.93.045425	journal	January 2016
Direct Identification of Dilute Surface Spins on Al 2 O 3 : Origin of Flux Noise in Quantum Circuits de Graaf, S. E.; Adamyan, A. A.; Lindström, T. Physical Review Letters, Vol. 118, Issue 5 https://doi.org/10.1103/PhysRevLett.118.057703	journal	January 2017
Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor Smits, Janis; Damron, Joshua T.; Kehayias, Pauli Science Advances, Vol. 5, Issue 7 https://doi.org/10.1126/sciadv.aaw7895	journal	July 2019
Single-protein spin resonance spectroscopy under ambient conditions Shi, F.; Zhang, Q.; Wang, P. Science, Vol. 347, Issue 6226 https://doi.org/10.1126/science.aaa2253	journal	March 2015
Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic Lovchinsky, I.; Sushkov, A. O.; Urbach, E. Science, Vol. 351, Issue 6275 https://doi.org/10.1126/science.aad8022	journal	February 2016
Submillihertz magnetic spectroscopy performed with a nanoscale quantum sensor Schmitt, Simon; Gefen, Tuvia; Stürner, Felix M. Science, Vol. 356, Issue 6340 https://doi.org/10.1126/science.aam5532	journal	May 2017
Quantum sensing with arbitrary frequency resolution Boss, J. M.; Cujia, K. S.; Zopes, J. Science, Vol. 356, Issue 6340 https://doi.org/10.1126/science.aam7009	journal	May 2017
Nanoscale nuclear magnetic resonance with chemical resolution Aslam, Nabeel; Pfender, Matthias; Neumann, Philipp Science, Vol. 357, Issue 6346 https://doi.org/10.1126/science.aam8697	journal	June 2017
Photophysics of Fluorescent Probes for Single-Molecule Biophysics and Super-Resolution Imaging Ha, Taekjip; Tinnefeld, Philip Annual Review of Physical Chemistry, Vol. 63, Issue 1 https://doi.org/10.1146/annurev-physchem-032210-103340	journal	May 2012
Emerging new strategies for successful metabolite identification in metabolomics Bingol, Kerem; Bruschweiler-Li, Lei; Li, Dawei Bioanalysis, Vol. 8, Issue 6 https://doi.org/10.4155/bio-2015-0004	journal	March 2016

Similar Records

Plasmonic sensors based on graphene and graphene hybrid materials

Journal Article · 2022 · Nano Convergence · OSTI ID:1872253

Zhang, Zhichao; Lee, Yeageun; Haque, Md Farhadul; +3 more

Materials challenges for quantum technologies based on color centers in diamond

Journal Article · 2021 · MRS Bulletin · OSTI ID:1870750

Rodgers, Lila H.; Hughes, Lillian B.; Xie, Mouzhe; +4 more

Nanoscopic lipid domains determined by microscopy and neutron scattering

Journal Article · 2024 · Methods · OSTI ID:2376309

Collier, Charles Patrick; Bolmatov, Dima; Elkins, James G.; +1 more

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
NV center
biocompatible functionalization
diamond surface modification
quantum sensing

Title: Biocompatible surface functionalization architecture for a diamond quantum sensor

Citation Formats

References (40)

Similar Records

Related Subjects