A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline

Bin, Jianhui; Obst-Huebl, Lieselotte; Mao, Jian-Hua; Nakamura, Kei; Geulig, Laura D.; Chang, Hang; Ji, Qing; He, Li; De Chant, Jared; Kober, Zachary; Gonsalves, Anthony J.; Bulanov, Stepan; Celniker, Susan E.; Schroeder, Carl B.; Geddes, Cameron G. R.; Esarey, Eric; Simmons, Blake A.; Schenkel, Thomas; Blakely, Eleanor A.; Steinke, Sven; Snijders, Antoine M.

doi:10.1038/s41598-022-05181-3

Title: A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline

Journal Article · 27 January 2022 · Scientific Reports

DOI: https://doi.org/10.1038/s41598-022-05181-3 · OSTI ID:1842393

;

; Chang, Hang; Ji, Qing; He, Li;

; Kober, Zachary;

; Bulanov, Stepan; Celniker, Susan E.;

;

; Esarey, Eric; Simmons, Blake A.; Schenkel, Thomas; Blakely, Eleanor A.;

Abstract Radiotherapy is the current standard of care for more than 50% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2 MeV energy at 0.2 Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10 mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35 Gy at ultra-high instantaneous dose rates of 10 ⁷ Gy/s. Dose-dependent cell survival measurements of human normal and tumor cells exposed to LD protons showed significantly higher cell survival of normal-cells compared to tumor-cells for total doses of 7 Gy and higher, which was not observed to the same extent for X-ray reference irradiations at clinical dose rates. These findings provide preliminary evidence that compact LD proton sources enable a new and promising platform for investigating the physical, chemical and biological mechanisms underlying the FLASH effect.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1842393

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 12; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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