Title: Protein Assembly by Design

Journal Article · · Chemical Reviews
ORCiD logo [1]; ORCiD logo [2];  [2];  [2]; ORCiD logo [2];  [2];  [2]; ORCiD logo [2];  [2]; ORCiD logo [2]; ORCiD logo [2]
  1. Univ. of California, San Diego, La Jolla, CA (United States); University of California, San Diego
  2. Univ. of California, San Diego, La Jolla, CA (United States)
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Proteins are nature’s primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes such as photosystem II and nitrogenase that drive biogeochemical cycles to cytoskeletal assemblies and muscle fibers for motion. Such natural systems have inspired extensive efforts in the rational design of artificial protein assemblies in the last two decades. As molecular building blocks, proteins are highly complex, in terms of both their three-dimensional structures and chemical compositions. To enable control over the self-assembly of such complex molecules, scientists have devised many creative strategies by combining tools and principles of experimental and computational biophysics, supramolecular chemistry, inorganic chemistry, materials science, and polymer chemistry, among others. Owing to these innovative strategies, what started as a purely structure-building exercise two decades ago has, in short order, led to artificial protein assemblies with unprecedented structures and functions and protein-based materials with unusual properties. Furthermore, our goal in this review is to give an overview of this exciting and highly interdisciplinary area of research, first outlining the design strategies and tools that have been devised for controlling protein self-assembly, then describing the diverse structures of artificial protein assemblies, and finally highlighting the emergent properties and functions of these assemblies.

Research Organization:
Univ. of Washington, Seattle, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
SC0019288
OSTI ID:
1841020
Journal Information:
Chemical Reviews, Journal Name: Chemical Reviews Journal Issue: 22 Vol. 121; ISSN 0009-2665
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English

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Engineering an intertwined form of CD2 for stability and assembly journal September 1998
Electron Microscopic Studies of Lipid Protein Films journal May 1971
Assembly of Tobacco Mosaic Virus Particle journal September 1971
Electron density map of apoferritin at 2.8-Å resolution journal January 1978
Design and self-assembly of two-dimensional DNA crystals journal August 1998
Two-dimensional crystallization technique for imaging macromolecules, with application to antigen–antibody–complement complexes journal January 1983
Origin of life: The RNA world journal February 1986
RNA evolution and the origins of life journal March 1989
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts journal February 1991
Lateral gene transfer and the nature of bacterial innovation journal May 2000
The dead-end elimination theorem and its use in protein side-chain positioning journal April 1992
A DNA-based method for rationally assembling nanoparticles into macroscopic materials journal August 1996
Insulin signalling and the regulation of glucose and lipid metabolism journal December 2001
The antiquity of RNA-based evolution journal July 2002
Auxetic materials: Avoiding the shrink journal October 2003
DNA nanotechnology journal November 2017
Open channel structure of MscL and the gating mechanism of mechanosensitive channels journal August 2002
Computational design of receptor and sensor proteins with novel functions journal May 2003
The principle of gating charge movement in a voltage-dependent K+ channel journal May 2003
Reticular synthesis and the design of new materials journal June 2003
Protein folding and misfolding journal December 2003
The molecular organization of cypovirus polyhedra journal March 2007
DNA-programmable nanoparticle crystallization journal January 2008
Assembly reflects evolution of protein complexes journal June 2008
Design of functional metalloproteins journal August 2009
Cell mechanics and the cytoskeleton journal January 2010
Reconfigurable self-assembly through chiral control of interfacial tension journal January 2012
Piezo proteins are pore-forming subunits of mechanically activated channels journal February 2012
Phase transitions in the assembly of multivalent signalling proteins journal March 2012
Principles for designing ideal protein structures journal November 2012
Proof of principle for epitope-focused vaccine design journal February 2014
Accurate design of co-assembling multi-component protein nanomaterials journal May 2014
Computational design of co-assembling protein–DNA nanowires journal September 2015
Rational design of α-helical tandem repeat proteins with closed architectures journal December 2015
Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals journal May 2016
Design of a hyperstable 60-subunit protein icosahedron journal June 2016
Designed proteins induce the formation of nanocage-containing extracellular vesicles journal November 2016
Evolution of a designed protein assembly encapsulating its own RNA genome journal December 2017
Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel journal August 2011
Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays journal March 2012
Protein camouflage in cytochrome c–calixarene complexes journal April 2012
Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP journal June 2013
Structure of a designed protein cage that self-assembles into a highly porous cube journal November 2014
Dynamic molecular crystals with switchable physical properties journal June 2016
Computational design of self-assembling cyclic protein homo-oligomers journal December 2016
Self-assembly and optically triggered disassembly of hierarchical dendron–virus complexes journal March 2010
Re-engineering protein interfaces yields copper-inducible ferritin cage assembly journal January 2013
Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments journal April 2013
Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm journal December 2017
Observation of gold sub-nanocluster nucleation within a crystalline protein cage journal March 2017
Terminal supraparticle assemblies from similarly charged protein molecules and nanoparticles journal May 2014
Self-assembly and modular functionalization of three-dimensional crystals from oppositely charged proteins journal July 2014
Protein crystalline frameworks with controllable interpenetration directed by dual supramolecular interactions journal August 2014
Molecular protein adaptor with genetically encoded interaction sites guiding the hierarchical assembly of plasmonically active nanoparticle architectures journal March 2015
Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency journal May 2015
States of Aggregation of Tobacco Mosaic Virus Protein journal January 1971
Polymerization of Tobacco Mosaic Virus Protein and its Control journal January 1971
Stimuli-responsive polypeptide vesicles by conformation-specific assembly journal March 2004
Deformation and failure of protein materials in physiologically extreme conditions and disease journal March 2009
DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles journal October 2010
Poisson's ratio and modern materials journal October 2011
Ordered nanoparticle arrays formed on engineered chaperonin protein templates journal November 2002
Nano-architectures by covalent assembly of molecular building blocks journal October 2007
Generation of protein lattices by fusing proteins with matching rotational symmetry journal July 2011
Challenges and opportunities for structural DNA nanotechnology journal November 2011
Electrostatic assembly of binary nanoparticle superlattices using protein cages journal December 2012
Physical virology journal October 2010
Protein structure prediction on the Web: a case study using the Phyre server journal February 2009
The ClusPro web server for protein–protein docking journal January 2017
Cryo-EM in drug discovery: achievements, limitations and prospects journal June 2018
The complex architecture of oxygenic photosynthesis journal December 2004
Filopodia: molecular architecture and cellular functions journal May 2008
The amyloid state and its association with protein misfolding diseases
  • Knowles, Tuomas P. J.; Vendruscolo, Michele; Dobson, Christopher M.
  • Nature Reviews Molecular Cell Biology, Vol. 15, Issue 6 https://doi.org/10.1038/nrm3810
journal May 2014
Prokaryotic cytoskeletons: protein filaments organizing small cells journal January 2018
Biogenesis and functions of bacterial S-layers journal February 2014
Design, structure and stability of a hyperthermophilic protein variant journal June 1998
One-step evolution of a dimer from a monomeric protein journal September 1995
Why protein crystals favour some space-groups over others journal December 1995
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating journal August 2002
Recent progress in the phase-transition mechanism and modulation of vanadium dioxide materials journal July 2018
Cooperative colloidal self-assembly of metal-protein superlattice wires journal September 2017
A cysteine-based molecular code informs collagen C-propeptide assembly journal October 2018
A five-residue motif for the design of domain swapping in proteins journal January 2019
Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages journal February 2019
A 3.8 Å resolution cryo-EM structure of a small protein bound to an imaging scaffold journal April 2019
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle journal September 2019
Diverse protein assembly driven by metal and chelating amino acids with selectivity and tunability journal December 2019
Engineering protein assemblies with allosteric control via monomer fold-switching journal December 2019
Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions journal July 2020
Two-tier supramolecular encapsulation of small molecules in a protein cage journal October 2020
Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials journal February 2021
Structural insights into photosystem II assembly journal April 2021
Dynamic protein assembly by programmable DNA strand displacement journal March 2018
Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly journal April 2018
Supercharging enables organized assembly of synthetic biomolecules journal January 2019
An efficient, step-economical strategy for the design of functional metalloproteins journal February 2019
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold journal February 2021
Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy journal March 2020
Supramolecular–covalent hybrid polymers for light-activated mechanical actuation journal June 2020
Biomimetic peptide self-assembly for functional materials journal September 2020
Advances in protein structure prediction and design journal August 2019
The tubulin code and its role in controlling microtubule properties and functions journal February 2020
Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks journal May 2018
Programmable design of orthogonal protein heterodimers journal December 2018
An ultra-stable gold-coordinated protein cage displaying reversible assembly journal May 2019
De novo protein design by citizen scientists journal June 2019
Controlling protein assembly on inorganic crystals through designed protein interfaces journal July 2019
Constructing protein polyhedra via orthogonal chemical interactions journal January 2020
Design of biologically active binary protein 2D materials journal January 2021
Computational design of transmembrane pores journal August 2020
Quadrivalent influenza nanoparticle vaccines induce broad protection journal March 2021
Multi-input chemical control of protein dimerization for programming graded cellular responses journal September 2019
Atomic insights into the genesis of cellular filaments by globular proteins journal August 2018
Receptor subtype discrimination using extensive shape complementary designed interfaces journal May 2019
Engineering and functionalization of large circular tandem repeat protein nanoparticles journal March 2020
The HDOCK server for integrated protein–protein docking journal April 2020
Engineering new catalytic activities in enzymes journal January 2020
Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly journal March 2017
Synthesis of protein–polymer conjugates journal January 2007
Porous protein frameworks with unsaturated metal centers in sterically encumbered coordination sites journal January 2011
Enzymatic functionalization of carbon–hydrogen bonds journal January 2011
Electrostatic self-assembly of virus–polymer complexes journal January 2011
Cucurbituril chemistry: a tale of supramolecular success journal January 2012
Toward functional nanocomposites: taking the best of nanoparticles, polymers, and small molecules journal January 2013
An ion signal responsive dynamic protein nano-spring constructed by high ordered host–guest recognition journal January 2016
Natural supramolecular protein assemblies journal January 2016
Peptide self-assembly for nanomaterials: the old new kid on the block journal January 2015
Design and engineering of artificial oxygen-activating metalloenzymes journal January 2016
Metal induced self-assembly of designed V-shape protein into 2D wavy supramolecular nanostructure journal January 2016
Domain-swapped cytochrome cb 562 dimer and its nanocage encapsulating a Zn–SO 4 cluster in the internal cavity journal January 2015
The construction of functional protein nanotubes by small molecule-induced self-assembly of cricoid proteins journal January 2016
Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein journal January 2016
Photocontrolled reversible morphology conversion of protein nanowires mediated by an azobenzene-cored dendrimer journal January 2016
Protein self-assembly via supramolecular strategies journal January 2016
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology journal January 2017
Dynamic protein self-assembly driven by host–guest chemistry and the folding–unfolding feature of a mutually exclusive protein journal January 2017
Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes journal January 2017
Protein cage assembly across multiple length scales journal January 2018
Coiled coil protein origami: from modular design principles towards biotechnological applications journal January 2018
Construction of protein assemblies by host–guest interactions with cucurbiturils journal January 2017
Photocontrolled protein assembly for constructing programmed two-dimensional nanomaterials journal January 2018
Porous protein crystals as scaffolds for enzyme immobilization journal January 2019
Tailoring lumazine synthase assemblies for bionanotechnology journal January 2018
Functional protein nanostructures: a chemical toolbox journal January 2018
Construction of supramolecular nanotubes from protein crystals journal January 2019
Disulfide-mediated reversible two-dimensional self-assembly of protein nanocages journal January 2019
Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging journal January 2019
Colloidal molecules and patchy particles: complementary concepts, synthesis and self-assembly journal January 2020
Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry journal January 2020
Molecular understanding of heteronuclear active sites in heme–copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling journal January 2021
Connectability of protein cages journal January 2020
Symmetry-related residues as promising hotspots for the evolution of de novo oligomeric enzymes journal January 2021
Coiled coils 9-to-5: rational de novo design of α-helical barrels with tunable oligomeric states journal January 2021
Host–guest chemistry of calixarene capsules journal January 2000
Protein-based materials, toward a new level of structural control journal January 2001
Artificial metalloenzymes: proteins as hosts for enantioselective catalysis journal January 2005
Rheological properties of peptide-based hydrogels for biomedical and other applications journal January 2010
Elastin-based materials journal January 2010
Hybrid nanomaterials for biomedical applications journal January 2010
Cyclodextrin-based inclusion complexation bridging supramolecular chemistry and macromolecular self-assembly journal January 2011
Protein cage nanoparticles as secondary building units for the synthesis of 3-dimensional coordination polymers journal January 2010
Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins journal January 2011
Protein assemblies by site-specific avidin–biotin interactions journal January 2011
Evaluation of a symmetry-based strategy for assembling protein complexes journal January 2011
A chemically-controlled supramolecular protein polymer formed by a myoglobin-based self-assembly system journal January 2011
Supramolecular assembling systems formed by heme–heme pocket interactions in hemoproteins journal January 2012
Self-assembly of glutathione S-transferase into nanowires journal January 2012
2D square arrays of protein nanocages through channel-directed electrostatic interactions with poly(α, l-lysine) journal January 2014
Metal-induced self-assembly of peroxiredoxin as a tool for sorting ultrasmall gold nanoparticles into one-dimensional clusters journal January 2014
Repurposing proteins for new bioinorganic functions journal May 2017
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein journal September 2004
Potential energy functions for atomic-level simulations of water and organic and biomolecular systems journal May 2005
Nanohedra: Using symmetry to design self assembling protein cages, layers, crystals, and filaments journal February 2001
An approach to crystallizing proteins by synthetic symmetrization journal October 2006
Light-activated DNA binding in a designed allosteric protein journal July 2008
In vitro self-assembly of tailorable nanotubes from a simple protein building block journal February 2008
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility journal December 2008
Metal templated design of protein interfaces journal December 2009
Elicitation of structure-specific antibodies by epitope scaffolds journal September 2010
Mechanics of bacteriophage maturation journal January 2012
Computational design of a protein crystal journal April 2012
Computational design of a symmetric homodimer using  -strand assembly journal December 2011
Exceptionally stable, redox-active supramolecular protein assemblies with emergent properties journal February 2014
Computational design of a self-assembling symmetrical β-propeller protein journal October 2014
DNA-mediated engineering of multicomponent enzyme crystals journal March 2015
Computational design and experimental verification of a symmetric protein homodimer journal August 2015
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core journal December 2016
Flexible, symmetry-directed approach to assembling protein cages journal July 2016
Conversion of monomeric protein L to an obligate dimer by computational protein design journal August 2001
A complete rule set for designing symmetry combination materials from protein molecules journal November 2020
On the Early Chemical History of the Earth and the Origin of Life journal April 1952
Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques. journal March 1992
Optimal sequence selection in proteins of known structure by simulated evolution. journal June 1994
Domain swapping: entangling alliances between proteins. journal April 1994
Principles of protein-protein interactions. journal January 1996
Symmetry and the energy landscapes of biomolecules journal December 1996
Direct measurement of salt-bridge solvation energies using a peptide model system: implications for protein stability. journal April 1996
Native protein sequences are close to optimal for their structures journal September 2000
The Many Faces of G Protein Signaling journal January 1998
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity journal March 2004
PDZ Domains: Structural Modules for Protein Complex Assembly journal February 2002
A New Approach to the Rapid Determination of Protein Side Chain Conformations journal June 1991
Protein crosslinking: Uses in chemistry, biology and biotechnology journal March 2020
Inclusion of neutral guests by water-soluble macrocyclic hosts – a comparative thermodynamic investigation with cyclodextrins, calixarenes and cucurbiturils journal November 2015
Gap junction structures. I. Correlated electron microscopy and x-ray diffraction. journal August 1977
High resolution AFM topographs of the Escherichia coli water channel aquaporin Z journal September 1999
In search of the ideal protein sequence journal January 1995
A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents journal October 2004
Design and application of stimulus-responsive peptide systems journal January 2007
The tobacco mosaic virus particle: structure and assembly journal March 1999
The Structure and Function of the Eukaryotic Ribosome journal May 2012
Denaturation of Heterogeneous DNA journal September 1997
Entropy and surface engineering in protein crystallization journal December 2005
Protein crystallization by surface entropy reduction: optimization of the SER strategy journal April 2007
Application of protein engineering to enhance crystallizability and improve crystal properties journal April 2010
3D domain swapping: As domains continue to swap journal June 2002
Allostery and cooperativity revisited journal August 2008
‘Crystal lattice engineering,’ an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines journal July 2007
Polymer-driven crystallization journal November 2007
A de novo designed protein-protein interface journal December 2007
S-layers: principles and applications journal September 2014
The Formation of Organic Compounds on the Primitive Earth journal August 1957
Two-dimensional crystallization of proteins on planar lipid films and structure determination by electron crystallography* journal January 1994
Designing and defining dynamic protein cage nanoassemblies in solution journal December 2016
Chemical Glycobiology journal March 2001
A Perspective on Enzyme Catalysis journal August 2003
Self-Assembly of Proteins into Designed Networks journal October 2003
How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations journal January 2004
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones journal May 2004
Computational Thermostabilization of an Enzyme journal May 2005
The Ins and Outs of DNA Transfer in Bacteria journal December 2005
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling journal August 2005
Viruses: Making Friends with Old Foes journal May 2006
Designed Synthesis of 3D Covalent Organic Frameworks journal April 2007
Designed Protein-Protein Association journal January 2008
Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces journal May 2011
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin journal May 2011
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold journal October 2011
Structure of a 16-nm Cage Designed by Using Protein Oligomers journal May 2012
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy journal May 2012
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity journal June 2012
Discovery of an Organic Trefoil Knot journal November 2012
Self-Assembling Cages from Coiled-Coil Peptide Modules journal April 2013
Computational design of water-soluble α-helical barrels journal October 2014
High thermodynamic stability of parametrically designed helical bundles journal October 2014
A designed supramolecular protein assembly with in vivo enzymatic activity journal December 2014
Organic Compound Synthes on the Primitive Eart: Several questions about the origin of life have been answered, but much remains to be studied journal July 1959
Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences journal April 1966
Molecular Code for Cooperativity in Hemoglobin journal January 1992
Protein electron transfer rates set by the bridging secondary and tertiary structure journal May 1991
Principles that Govern the Folding of Protein Chains journal July 1973
Host-Guest Chemistry: Complexes between organic compounds simulate the substrate selectivity of enzymes journal March 1974
Supramolecular Chemistry: Receptors, Catalysts, and Carriers journal February 1985
De Novo Protein Design: Fully Automated Sequence Selection journal October 1997
High-Resolution Protein Design with Backbone Freedom journal November 1998
Structure of the MscL Homolog from Mycobacterium tuberculosis: A Gated Mechanosensitive Ion Channel journal December 1998
X-ray Crystal Structures of 70S Ribosome Functional Complexes journal September 1999
Quality Control by DNA Repair journal December 1999
Structural Evidence for Evolution of the beta /alpha Barrel Scaffold by Gene Duplication and Fusion journal September 2000
Characterization of a helical protein designed from first principles journal August 1988
The design of molecular hosts, guests, and their complexes journal May 1988
Three-dimensional structure of myosin subfragment-1: a molecular motor journal July 1993
Principles of assembly reveal a periodic table of protein complexes journal December 2015
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces journal June 2015
De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity journal May 2016
Accurate design of megadalton-scale two-component icosahedral protein complexes journal July 2016
Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes journal March 2017
Accurate computational design of multipass transmembrane proteins journal March 2018
Evolution of a highly active and enantiospecific metalloenzyme from short peptides journal December 2018
De novo design of self-assembling helical protein filaments journal November 2018
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis journal May 2019
De novo design of tunable, pH-driven conformational changes journal May 2019
De novo design of protein logic gates journal April 2020
Designed proteins assemble antibodies into modular nanocages journal April 2021
Structure, Dynamics, Assembly, and Evolution of Protein Complexes journal June 2015
Allostery and the Monod-Wyman-Changeux Model After 50 Years journal June 2012
Disulfide Bonding in Protein Biophysics journal June 2012
Metals in Protein–Protein Interfaces journal May 2014
Geometric Principles for Designing Highly Symmetric Self-Assembling Protein Nanomaterials journal May 2017
Theoretical and Computational Protein Design journal May 2011
Mechanisms of Virus Assembly journal April 2015
Structure and Function of Photosystems i and ii journal June 2006
Evolution and the Tertiary Structure of Proteins journal June 1984
Hemoglobin journal June 1970
Carbohydrate-Binding Proteins: Tertiary Structures and Protein-Sugar Interactions journal June 1986
Structure and Function of Voltage-Gated Ion Channels journal June 1995
Structural Basis of Lectin-Carbohydrate Recognition journal June 1996
Structural Insights into Microtubule Function journal June 2000
DNA Replication Fidelity journal June 2000
Mechanical Signaling in Networks of Motor and Cytoskeletal Proteins journal June 2009
Structural Symmetry and Protein Function journal June 2000
The Protein Folding Problem journal June 2008
THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective journal October 1997
Plant Viruses as Biotemplates for Materials and Their Use in Nanotechnology journal September 2008
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments journal April 2003
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance journal April 1999
I-TASSER server for protein 3D structure prediction journal January 2008
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family journal June 2012
Protein assembly systems in natural and synthetic biology journal March 2020
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors journal February 2000
Actin stress fibers – assembly, dynamics and biological roles journal January 2012
Symmetry based assembly of a 2 dimensional protein lattice journal April 2017
A New Generation of Statistical Potentials for Proteins journal June 2006
Protein Structure Prediction: Recognition of Primary, Secondary, and Tertiary Structural Features from Amino Acid Sequence journal January 1995
Self-Assembly of Switchable Protein Nanocages via Allosteric Effect journal August 2021
Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications journal April 2019
S-Layer Protein Self-Assembly journal January 2013
Hierarchically Ordered Supramolecular Protein-Polymer Composites with Thermoresponsive Properties journal May 2015
Disulfide bond structures of IgG molecules: Structural variations, chemical modifications and possible impacts to stability and biological function journal January 2012
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer journal November 2016
De novo design of a homo-trimeric amantadine-binding protein journal December 2019
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens journal August 2020

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Interfaces
Peptides and proteins
Protein structure
Self organization
Supramolecular structures and assemblies