Advanced genomics identifies growth effectors for proteotoxic ER stress recovery in Arabidopsis thaliana

Ko, Dae Kwan; Brandizzi, Federica

doi:10.1038/s42003-021-02964-8

Title: Advanced genomics identifies growth effectors for proteotoxic ER stress recovery in Arabidopsis thaliana

Journal Article · 11 January 2022 · Communications Biology

DOI: https://doi.org/10.1038/s42003-021-02964-8 · OSTI ID:1839311

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Abstract Adverse environmental and pathophysiological situations can overwhelm the biosynthetic capacity of the endoplasmic reticulum (ER), igniting a potentially lethal condition known as ER stress. ER stress hampers growth and triggers a conserved cytoprotective signaling cascade, the unfolded protein response (UPR) for ER homeostasis. As ER stress subsides, growth is resumed. Despite the pivotal role of the UPR in growth restoration, the underlying mechanisms for growth resumption are yet unknown. To discover these, we undertook a genomics approach in the model plant species Arabidopsis thaliana and mined the gene reprogramming roles of the UPR modulators, basic leucine zipper28 (bZIP28) and bZIP60, in ER stress resolution. Through a network modeling and experimental validation, we identified key genes downstream of the UPR bZIP-transcription factors (bZIP-TFs), and demonstrated their functional roles. Our analyses have set up a critical pipeline for functional gene discovery in ER stress resolution with broad applicability across multicellular eukaryotes.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018409; FG02-91ER20021

OSTI ID:: 1839311

Journal Information:: Communications Biology, Journal Name: Communications Biology Journal Issue: 1 Vol. 5; ISSN 2399-3642

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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