Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Schiffer, Jodie A.; Stumbur, Stephanie V.; Seyedolmohadesin, Maedeh; Xu, Yuyan; Serkin, William T.; McGowan, Natalie G.; Banjo, Oluwatosin; Torkashvand, Mahdi; Lin, Albert; Hosea, Ciara N.; Assié, Adrien; Samuel, Buck S.; O’Donnell, Michael P.; Venkatachalam, Vivek; Apfeld, Javier; Weaver, ed., Benjamin

doi:10.1371/journal.ppat.1010112

Title: Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Journal Article · 22 December 2021 · PLoS Pathogens

DOI: https://doi.org/10.1371/journal.ppat.1010112 · OSTI ID:1837327

; Stumbur, Stephanie V.; Seyedolmohadesin, Maedeh;

;

; Banjo, Oluwatosin;

;

; Hosea, Ciara N.;

;

; Venkatachalam, Vivek;

; Weaver, ed., Benjamin

Hydrogen peroxide (H ₂ O ₂ ) is the most common chemical threat that organisms face. Here, we show that H ₂ O ₂ alters the bacterial food preference of Caenorhabditis elegans , enabling the nematodes to find a safe environment with food. H ₂ O ₂ induces the nematodes to leave food patches of laboratory and microbiome bacteria when those bacterial communities have insufficient H ₂ O ₂ -degrading capacity. The nematode’s behavior is directed by H ₂ O ₂ -sensing neurons that promote escape from H ₂ O ₂ and by bacteria-sensing neurons that promote attraction to bacteria. However, the input for H ₂ O ₂ -sensing neurons is removed by bacterial H ₂ O ₂ -degrading enzymes and the bacteria-sensing neurons’ perception of bacteria is prevented by H ₂ O ₂ . The resulting cross-attenuation provides a general mechanism that ensures the nematode’s behavior is faithful to the lethal threat of hydrogen peroxide, increasing the nematode’s chances of finding a niche that provides both food and protection from hydrogen peroxide.

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Sponsoring Organization:: USDOE

OSTI ID:: 1837327

Journal Information:: PLoS Pathogens, Journal Name: PLoS Pathogens Journal Issue: 12 Vol. 17; ISSN 1553-7374

Publisher:: Public Library of Science (PLoS)Copyright Statement

Country of Publication:: United States

Language:: English

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