Mutations in artificial self-replicating tiles: A step toward Darwinian evolution
Abstract
Artificial self-replication and exponential growth holds the promise of gaining a better understanding of fundamental processes in nature but also of evolving new materials and devices with useful properties. A system of DNA origami dimers has been shown to exhibit exponential growth and selection. Here we introduce mutation and growth advantages to study the possibility of Darwinian-like evolution. We seed and grow one dimer species, AB, from A and B monomers that doubles in each cycle. A similar species from C and D monomers can replicate at a controlled growth rate of two or four per cycle but is unseeded. Introducing a small mutation rate so that AB parents infrequently template CD offspring we show experimentally that the CD species can take over the system in approximately six generations in an advantageous environment. This demonstration opens the door to the use of evolution in materials design.
- Authors:
-
[1];
[1];
[1]
- Department of Physics, New York University, New York, NY 10003,
- Department of Chemistry, New York University, New York, NY 10003
- Publication Date:
- Research Org.:
- Northwestern Univ., Evanston, IL (United States); New York Univ. (NYU), NY (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); US Army Research Office (ARO); US Department of the Navy, Office of Naval Research (ONR)
- OSTI Identifier:
- 1834244
- Alternate Identifier(s):
- OSTI ID: 1904563
- Grant/Contract Number:
- SC0007991; SC0000989; EFRI-1332411; CCF-1526650; DMR-1420073; W911NF-11-1-0024; N000140911118; RGP0010/2017
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 118 Journal Issue: 50; Journal ID: ISSN 0027-8424
- Publisher:
- Proceedings of the National Academy of Sciences
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; artificial self-replication; mutation; Darwinian evolution; exponential growth; cross-tile DNA origami
Citation Formats
Zhou, Feng, Sha, Ruojie, Ni, Heng, Seeman, Nadrian, and Chaikin, Paul. Mutations in artificial self-replicating tiles: A step toward Darwinian evolution. United States: N. p., 2021.
Web. doi:10.1073/pnas.2111193118.
Zhou, Feng, Sha, Ruojie, Ni, Heng, Seeman, Nadrian, & Chaikin, Paul. Mutations in artificial self-replicating tiles: A step toward Darwinian evolution. United States. https://doi.org/10.1073/pnas.2111193118
Zhou, Feng, Sha, Ruojie, Ni, Heng, Seeman, Nadrian, and Chaikin, Paul. Mon .
"Mutations in artificial self-replicating tiles: A step toward Darwinian evolution". United States. https://doi.org/10.1073/pnas.2111193118.
@article{osti_1834244,
title = {Mutations in artificial self-replicating tiles: A step toward Darwinian evolution},
author = {Zhou, Feng and Sha, Ruojie and Ni, Heng and Seeman, Nadrian and Chaikin, Paul},
abstractNote = {Artificial self-replication and exponential growth holds the promise of gaining a better understanding of fundamental processes in nature but also of evolving new materials and devices with useful properties. A system of DNA origami dimers has been shown to exhibit exponential growth and selection. Here we introduce mutation and growth advantages to study the possibility of Darwinian-like evolution. We seed and grow one dimer species, AB, from A and B monomers that doubles in each cycle. A similar species from C and D monomers can replicate at a controlled growth rate of two or four per cycle but is unseeded. Introducing a small mutation rate so that AB parents infrequently template CD offspring we show experimentally that the CD species can take over the system in approximately six generations in an advantageous environment. This demonstration opens the door to the use of evolution in materials design.},
doi = {10.1073/pnas.2111193118},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 50,
volume = 118,
place = {United States},
year = {Mon Dec 06 00:00:00 EST 2021},
month = {Mon Dec 06 00:00:00 EST 2021}
}
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https://doi.org/10.1073/pnas.2111193118
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