Reconfigurable Two‐Dimensional DNA Lattices: Static and Dynamic Angle Control

Wang, Wen; Chen, Chunyu; Vecchioni, Simon; Zhang, Tianqing; Wu, Chengxian; Ohayon, Yoel P.; Sha, Ruojie; Seeman, Nadrian C.; Wei, Bryan

doi:10.1002/ange.202112487

Title: Reconfigurable Two‐Dimensional DNA Lattices: Static and Dynamic Angle Control

Journal Article · 04 November 2021 · Angewandte Chemie

DOI: https://doi.org/10.1002/ange.202112487 · OSTI ID:1829363

Wang, Wen ^[1]; Chen, Chunyu ^[1]; Vecchioni, Simon ^[2]; Zhang, Tianqing ^[1]; Wu, Chengxian ^[1]; Ohayon, Yoel P. ^[2]; Sha, Ruojie ^[2]; Seeman, Nadrian C. ^[2];

^[1]

School of Life Sciences Tsinghua University-Peking University Center for Life Sciences Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China
Department of Chemistry New York University New York New York 10003 USA

Abstract Branched DNA motifs serve as the basic construction elements for all synthetic DNA nanostructures. However, precise control of branching orientation remains a key challenge to further heighten the overall structural order. In this study, we use two strategies to control the branching orientation. The first one is based on immobile Holliday junctions which employ specific nucleotide sequences at the branch points which dictate their orientation. The second strategy is to use angle‐enforcing struts to fix the branching orientation with flexible spacers at the branch points. We have also demonstrated that the branching orientation control can be achieved dynamically, either by canonical Watson–Crick base pairing or non‐canonical nucleobase interactions (e.g., i‐motif and G‐quadruplex). With precise angle control and feedback from the chemical environment, these results will enable novel DNA nanomechanical sensing devices, and precisely‐ordered three‐dimensional architectures.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0007991

OSTI ID:: 1829363

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Journal Issue: 49 Vol. 133; ISSN 0044-8249

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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