Utilizing Plant Synthetic Biology to Improve Human Health and Wellness

Barnum, Collin R.; Endelman, Benjamin J.; Shih, Patrick M.

doi:10.3389/fpls.2021.691462

Title: Utilizing Plant Synthetic Biology to Improve Human Health and Wellness

Journal Article · 23 August 2021 · Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2021.691462 · OSTI ID:1825245

Barnum, Collin R. ^[1]; Endelman, Benjamin J. ^[1]; Shih, Patrick M. ^[2]

Univ. of California, Davis, CA (United States)
Univ. of California, Davis, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Univ. of California, Berkeley, CA (United States)

Plants offer a vast source of bioactive chemicals with the potential to improve human health through the prevention and treatment of disease. However, many potential therapeutics are produced in small amounts or in species that are difficult to cultivate. The rapidly evolving field of plant synthetic biology provides tools to capitalize on the inventive chemistry of plants by transferring metabolic pathways for therapeutics into far more tenable plants, increasing our ability to produce complex pharmaceuticals in well-studied plant systems. Plant synthetic biology also provides methods to enhance the ability to fortify crops with nutrients and nutraceuticals. In this review, we discuss (1) the potential of plant synthetic biology to improve human health by generating plants that produce pharmaceuticals, nutrients, and nutraceuticals and (2) the technological challenges hindering our ability to generate plants producing health-promoting small molecules.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1825245

Journal Information:: Frontiers in Plant Science, Journal Name: Frontiers in Plant Science Vol. 12; ISSN 1664-462X

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

References (109)

Considerations in adapting CRISPR/Cas9 in nongenetic model plant systems Shan, Shengchen; Soltis, Pamela S.; Soltis, Douglas E. Applications in Plant Sciences, Vol. 8, Issue 1 https://doi.org/10.1002/aps3.11314	journal	January 2020
Caffeic acid production enhancement by engineering a phenylalanine over-producing Escherichia coli strain : Caffeic Acid Production Huang, Qin; Lin, Yuheng; Yan, Yajun Biotechnology and Bioengineering, Vol. 110, Issue 12 https://doi.org/10.1002/bit.24988	journal	July 2013
The Search for Novel Human Pancreatic α-Amylase Inhibitors: High-Throughput Screening of Terrestrial and Marine Natural Product Extracts Tarling, Chris A.; Woods, Kate; Zhang, Ran ChemBioChem, Vol. 9, Issue 3 https://doi.org/10.1002/cbic.200700470	journal	February 2008
Dietary anthocyanin-rich plants: Biochemical basis and recent progress in health benefits studies Tsuda, Takanori Molecular Nutrition & Food Research, Vol. 56, Issue 1 https://doi.org/10.1002/mnfr.201100526	journal	November 2011
Metabolic Engineering for Microbial Production of Aromatic Amino Acids and Derived Compounds Bongaerts, Johannes; Krämer, Marco; Müller, Ulrike Metabolic Engineering, Vol. 3, Issue 4 https://doi.org/10.1006/mben.2001.0196	journal	October 2001
Engineering terpenoid production through transient expression in Nicotiana benthamiana Reed, James; Osbourn, Anne Plant Cell Reports, Vol. 37, Issue 10 https://doi.org/10.1007/s00299-018-2296-3	journal	May 2018
Plant mineral transport systems and the potential for crop improvement Yadav, Bindu; Jogawat, Abhimanyu; LalNITRATE, Shambhu Krishan Planta, Vol. 253, Issue 2 https://doi.org/10.1007/s00425-020-03551-7	journal	January 2021
Fruit and vegetable access in four low-income food deserts communities in Minnesota Hendrickson, Deja; Smith, Chery; Eikenberry, Nicole Agriculture and Human Values, Vol. 23, Issue 3 https://doi.org/10.1007/s10460-006-9002-8	journal	October 2006
Papaver somniferum L. taxonomy, uses and new insight in poppy alkaloid pathways Labanca, Fabiana; Ovesnà, Jaroslava; Milella, Luigi Phytochemistry Reviews, Vol. 17, Issue 4 https://doi.org/10.1007/s11101-018-9563-3	journal	March 2018
Regulation of Carotenoid Content in Tomato by Silencing of Lycopene β/ε-Cyclase Genes Ma, Chao; Ma, Binggang; He, Juan Plant Molecular Biology Reporter, Vol. 29, Issue 1 https://doi.org/10.1007/s11105-010-0211-3	journal	May 2010
Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants Yang, Lei; Yang, Changqing; Li, Chenyi Science Bulletin, Vol. 61, Issue 1 https://doi.org/10.1007/s11434-015-0929-2	journal	January 2016
Rapid genotype “independent” Zea mays L. (maize) transformation via direct somatic embryogenesis Lowe, Keith; La Rota, Mauricio; Hoerster, George In Vitro Cellular & Developmental Biology - Plant, Vol. 54, Issue 3 https://doi.org/10.1007/s11627-018-9905-2	journal	April 2018
Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production Matsuura, Hélio Nitta; Malik, Sonia; de Costa, Fernanda Molecular Biotechnology, Vol. 60, Issue 2 https://doi.org/10.1007/s12033-017-0056-1	journal	December 2017
Supercritical extraction of taxol from the bark of Taxus brevifolia Jennings, David W.; Deutsch, Howard M.; Zalkow, Leon H. The Journal of Supercritical Fluids, Vol. 5, Issue 1 https://doi.org/10.1016/0896-8446(92)90033-G	journal	March 1992
Bioactive natural compounds against human coronaviruses: a review and perspective Xian, Yanfang; Zhang, Juan; Bian, Zhaoxiang Acta Pharmaceutica Sinica B, Vol. 10, Issue 7 https://doi.org/10.1016/j.apsb.2020.06.002	journal	July 2020
Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases Pannu, Naveet; Bhatnagar, Archana Biomedicine & Pharmacotherapy, Vol. 109 https://doi.org/10.1016/j.biopha.2018.11.075	journal	January 2019
Discovery and resupply of pharmacologically active plant-derived natural products: A review Atanasov, Atanas G.; Waltenberger, Birgit; Pferschy-Wenzig, Eva-Maria Biotechnology Advances, Vol. 33, Issue 8 https://doi.org/10.1016/j.biotechadv.2015.08.001	journal	December 2015
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties Zhang, Xumin; Xie, Long; Long, Jiaying Chemico-Biological Interactions, Vol. 339 https://doi.org/10.1016/j.cbi.2020.109268	journal	April 2021
A Two-Step Orthogonal Chromatographic Process for Purifying the Molecular Adjuvant QS-21 with High Purity and Yield Qi, Yizhi; Fox, Christopher B. Journal of Chromatography A, Vol. 1635 https://doi.org/10.1016/j.chroma.2020.461705	journal	January 2021
The emerging field of transport engineering of plant specialized metabolites Nour-Eldin, Hussam Hassan; Halkier, Barbara Ann Current Opinion in Biotechnology, Vol. 24, Issue 2 https://doi.org/10.1016/j.copbio.2012.09.006	journal	April 2013
Creating plant molecular factories for industrial and nutritional isoprenoid production Nogueira, Marilise; Enfissi, Eugenia MA; Almeida, Juliana Current Opinion in Biotechnology, Vol. 49 https://doi.org/10.1016/j.copbio.2017.08.002	journal	February 2018
Moringa plants: Bioactive compounds and promising applications in food products Saucedo-Pompa, S.; Torres-Castillo, J. A.; Castro-López, C. Food Research International, Vol. 111 https://doi.org/10.1016/j.foodres.2018.05.062	journal	September 2018
Plant and bacterial systems biology as platform for plant synthetic bio(techno)logy Zurbriggen, Matias D.; Moor, Alina; Weber, Wilfried Journal of Biotechnology, Vol. 160, Issue 1-2 https://doi.org/10.1016/j.jbiotec.2012.01.014	journal	July 2012
Specificity of Ocimum basilicum geraniol synthase modified by its expression in different heterologous systems Fischer, Marc J. C.; Meyer, Sophie; Claudel, Patricia Journal of Biotechnology, Vol. 163, Issue 1 https://doi.org/10.1016/j.jbiotec.2012.10.012	journal	January 2013
Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells Malhotra, Karan; Subramaniyan, Mayavan; Rawat, Khushboo Molecular Plant, Vol. 9, Issue 11 https://doi.org/10.1016/j.molp.2016.09.013	journal	November 2016
Development of “Purple Endosperm Rice” by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System Zhu, Qinlong; Yu, Suize; Zeng, Dongchang Molecular Plant, Vol. 10, Issue 7 https://doi.org/10.1016/j.molp.2017.05.008	journal	July 2017
Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis Torrens-Spence, Michael P.; Pluskal, Tomáš; Li, Fu-Shuang Molecular Plant, Vol. 11, Issue 1 https://doi.org/10.1016/j.molp.2017.12.007	journal	January 2018
From Golden Rice to aSTARice: Bioengineering Astaxanthin Biosynthesis in Rice Endosperm Zhu, Qinlong; Zeng, Dongchang; Yu, Suize Molecular Plant, Vol. 11, Issue 12 https://doi.org/10.1016/j.molp.2018.09.007	journal	December 2018
The chemical logic of plant natural product biosynthesis Anarat-Cappillino, Gülbenk; Sattely, Elizabeth S. Current Opinion in Plant Biology, Vol. 19 https://doi.org/10.1016/j.pbi.2014.03.007	journal	June 2014
Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants Blažević, Ivica; Montaut, Sabine; Burčul, Franko Phytochemistry, Vol. 169 https://doi.org/10.1016/j.phytochem.2019.112100	journal	January 2020
Metabolic engineering to increase crop yield: From concept to execution Skraly, Frank A.; Ambavaram, Madana M. R.; Peoples, Oliver Plant Science, Vol. 273 https://doi.org/10.1016/j.plantsci.2018.03.011	journal	August 2018
From plant metabolic engineering to plant synthetic biology: The evolution of the design/build/test/learn cycle Pouvreau, Benjamin; Vanhercke, Thomas; Singh, Surinder Plant Science, Vol. 273 https://doi.org/10.1016/j.plantsci.2018.03.035	journal	August 2018
Bioactive compounds from medicinal plants: Focus on Piper species Mgbeahuruike, E. E.; Yrjönen, T.; Vuorela, H. South African Journal of Botany, Vol. 112 https://doi.org/10.1016/j.sajb.2017.05.007	journal	September 2017
Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein Tanaka, Yoshiki; Iwaki, Shigehiro; Tsukazaki, Tomoya Structure, Vol. 25, Issue 9 https://doi.org/10.1016/j.str.2017.07.009	journal	September 2017
Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications Wu, Gang; Yan, Qiang; Jones, J. Andrew Trends in Biotechnology, Vol. 34, Issue 8 https://doi.org/10.1016/j.tibtech.2016.02.010	journal	August 2016
Biosynthesis of glucosinolates – gene discovery and beyond Sønderby, Ida E.; Geu-Flores, Fernando; Halkier, Barbara A. Trends in Plant Science, Vol. 15, Issue 5 https://doi.org/10.1016/j.tplants.2010.02.005	journal	May 2010
Exploring the Diversity of Plant Metabolism Fang, Chuanying; Fernie, Alisdair R.; Luo, Jie Trends in Plant Science, Vol. 24, Issue 1 https://doi.org/10.1016/j.tplants.2018.09.006	journal	January 2019
A Highly Efficient Agrobacterium-Mediated Method for Transient Gene Expression and Functional Studies in Multiple Plant Species Zhang, Youjun; Chen, Moxian; Siemiatkowska, Beata Plant Communications, Vol. 1, Issue 5 https://doi.org/10.1016/j.xplc.2020.100028	journal	September 2020
Extending shikimate pathway for the production of muconic acid and its precursor salicylic acid in Escherichia coli Lin, Yuheng; Sun, Xinxiao; Yuan, Qipeng Metabolic Engineering, Vol. 23 https://doi.org/10.1016/j.ymben.2014.02.009	journal	May 2014
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules Reed, James; Stephenson, Michael J.; Miettinen, Karel Metabolic Engineering, Vol. 42 https://doi.org/10.1016/j.ymben.2017.06.012	journal	July 2017
Recent Developments along the Analytical Process for Metabolomics Workflows González-Riano, Carolina; Dudzik, Danuta; Garcia, Antonia Analytical Chemistry, Vol. 92, Issue 1 https://doi.org/10.1021/acs.analchem.9b04553	journal	October 2019
Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals Calgaro-Kozina, Amy; Vuu, Khanh M.; Keasling, Jay D. ACS Central Science, Vol. 6, Issue 8 https://doi.org/10.1021/acscentsci.0c00241	journal	July 2020
Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis Schultz, Bailey J.; Kim, Seung Yeon; Lau, Warren Journal of the American Chemical Society, Vol. 141, Issue 49 https://doi.org/10.1021/jacs.9b10717	journal	November 2019
Over-Expression of an Arabidopsis Zinc Transporter in Hordeum Vulgare Increases Short-Term Zinc Uptake after Zinc Deprivation and Seed Zinc Content Ramesh, Sunita A.; Choimes, Steve; Schachtman, Daniel P. Plant Molecular Biology, Vol. 54, Issue 3 https://doi.org/10.1023/B:PLAN.0000036370.70912.34	journal	February 2004
NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds Nour-Eldin, Hussam Hassan; Andersen, Tonni Grube; Burow, Meike Nature, Vol. 488, Issue 7412 https://doi.org/10.1038/nature11285	journal	August 2012
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors Butelli, Eugenio; Titta, Lucilla; Giorgio, Marco Nature Biotechnology, Vol. 26, Issue 11 https://doi.org/10.1038/nbt.1506	journal	October 2008
Increased bioavailable vitamin B6 in field-grown transgenic cassava for dietary sufficiency Li, Kuan-Te; Moulin, Michael; Mangel, Nathalie Nature Biotechnology, Vol. 33, Issue 10 https://doi.org/10.1038/nbt.3318	journal	October 2015
Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering Blancquaert, Dieter; Van Daele, Jeroen; Strobbe, Simon Nature Biotechnology, Vol. 33, Issue 10 https://doi.org/10.1038/nbt.3358	journal	September 2015
Genome editing of upstream open reading frames enables translational control in plants Zhang, Huawei; Si, Xiaomin; Ji, Xiang Nature Biotechnology, Vol. 36, Issue 9 https://doi.org/10.1038/nbt.4202	journal	October 2018
De novo domestication of wild tomato using genome editing Zsögön, Agustin; Čermák, Tomáš; Naves, Emmanuel Rezende Nature Biotechnology, Vol. 36, Issue 12 https://doi.org/10.1038/nbt.4272	journal	October 2018
Domestication of wild tomato is accelerated by genome editing Li, Tingdong; Yang, Xinping; Yu, Yuan Nature Biotechnology, Vol. 36, Issue 12 https://doi.org/10.1038/nbt.4273	journal	October 2018
Improving the nutritional value of Golden Rice through increased pro-vitamin A content Paine, Jacqueline A.; Shipton, Catherine A.; Chaggar, Sunandha Nature Biotechnology, Vol. 23, Issue 4 https://doi.org/10.1038/nbt1082	journal	March 2005
Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants Wu, Shuiqin; Schalk, Michel; Clark, Anthony Nature Biotechnology, Vol. 24, Issue 11, p. 1441-1447 https://doi.org/10.1038/nbt1251	journal	October 2006
A robust gene-stacking method utilizing yeast assembly for plant synthetic biology Shih, Patrick M.; Vuu, Khanh; Mansoori, Nasim Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13215	journal	October 2016
An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole Payne, Richard M. E.; Xu, Deyang; Foureau, Emilien Nature Plants, Vol. 3, Issue 2 https://doi.org/10.1038/nplants.2016.208	journal	January 2017
Demystifying traditional herbal medicine with modern approach Li, Fu-Shuang; Weng, Jing-Ke Nature Plants, Vol. 3, Issue 8 https://doi.org/10.1038/nplants.2017.109	journal	July 2017
Structural basis for xenobiotic extrusion by eukaryotic MATE transporter Miyauchi, Hirotake; Moriyama, Satomi; Kusakizako, Tsukasa Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01541-0	journal	November 2017
Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9 Dong, Oliver Xiaoou; Yu, Shu; Jain, Rashmi Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-14981-y	journal	March 2020
Rapid improvement of domestication traits in an orphan crop by genome editing Lemmon, Zachary H.; Reem, Nathan T.; Dalrymple, Justin Nature Plants, Vol. 4, Issue 10 https://doi.org/10.1038/s41477-018-0259-x	journal	October 2018
The emerging and uncultivated potential of CRISPR technology in plant science Zhang, Yingxiao; Malzahn, Aimee A.; Sretenovic, Simon Nature Plants, Vol. 5, Issue 8 https://doi.org/10.1038/s41477-019-0461-5	journal	July 2019
Revolutionizing agriculture with synthetic biology Wurtzel, Eleanore T.; Vickers, Claudia E.; Hanson, Andrew D. Nature Plants, Vol. 5, Issue 12 https://doi.org/10.1038/s41477-019-0539-0	journal	November 2019
PAM-less plant genome editing using a CRISPR–SpRY toolbox Ren, Qiurong; Sretenovic, Simon; Liu, Shishi Nature Plants, Vol. 7, Issue 1 https://doi.org/10.1038/s41477-020-00827-4	journal	January 2021
Highly efficient DNA-free plant genome editing using virally delivered CRISPR–Cas9 Ma, Xiaonan; Zhang, Xiaoyan; Liu, Huimin Nature Plants, Vol. 6, Issue 7 https://doi.org/10.1038/s41477-020-0704-5	journal	June 2020
Transient reprogramming of crop plants for agronomic performance Torti, Stefano; Schlesier, René; Thümmler, Anka Nature Plants, Vol. 7, Issue 2 https://doi.org/10.1038/s41477-021-00851-y	journal	February 2021
Discovery and engineering of colchicine alkaloid biosynthesis Nett, Ryan S.; Lau, Warren; Sattely, Elizabeth S. Nature, Vol. 584, Issue 7819 https://doi.org/10.1038/s41586-020-2546-8	journal	July 2020
Single genetic locus improvement of iron, zinc and β-carotene content in rice grains Singh, Simrat Pal; Gruissem, Wilhelm; Bhullar, Navreet K. Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-07198-5	journal	July 2017
Iron biofortification in rice by the introduction of multiple genes involved in iron nutrition Masuda, Hiroshi; Ishimaru, Yasuhiro; Aung, May Sann Scientific Reports, Vol. 2, Issue 1 https://doi.org/10.1038/srep00543	journal	July 2012
Synthetic biology strategies toward heterologous phytochemical production Kotopka, Benjamin J.; Li, Yanran; Smolke, Christina D. Natural Product Reports, Vol. 35, Issue 9 https://doi.org/10.1039/C8NP00028J	journal	January 2018
Designing and Transgenic Expression of Melanin Gene in Tobacco Trichome and Cotton Fiber Xu, X.; Wu, M.; Zhao, Q. Plant Biology, Vol. 9, Issue 1 https://doi.org/10.1055/s-2006-924346	journal	January 2007
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19 E -geissoschizine Qu, Yang; Easson, Michael E. A. M.; Simionescu, Razvan Proceedings of the National Academy of Sciences, Vol. 115, Issue 12 https://doi.org/10.1073/pnas.1719979115	journal	March 2018
Synthetic conversion of leaf chloroplasts into carotenoid-rich plastids reveals mechanistic basis of natural chromoplast development Llorente, Briardo; Torres-Montilla, Salvador; Morelli, Luca Proceedings of the National Academy of Sciences, Vol. 117, Issue 35 https://doi.org/10.1073/pnas.2004405117	journal	August 2020
The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health Brose, Julia; Lau, Kin H.; Dang, Thu Thuy Thi G3 Genes\|Genomes\|Genetics, Vol. 11, Issue 4 https://doi.org/10.1093/g3journal/jkab058	journal	March 2021
Soybean seeds expressing feedback-insensitive cystathionine γ-synthase exhibit a higher content of methionine Song, Shikui; Hou, Wensheng; Godo, Itamar Journal of Experimental Botany, Vol. 64, Issue 7 https://doi.org/10.1093/jxb/ert053	journal	March 2013
Phenylpropanoid Biosynthesis Vogt, Thomas Molecular Plant, Vol. 3, Issue 1 https://doi.org/10.1093/mp/ssp106	journal	January 2010
Production of the Cancer-Preventive Glucoraphanin in Tobacco Mikkelsen, Michael Dalgaard; Olsen, Carl Erik; Halkier, Barbara Ann Molecular Plant, Vol. 3, Issue 4 https://doi.org/10.1093/mp/ssq020	journal	July 2010
Synthesis of Seed-Specific Bidirectional Promoters for Metabolic Engineering of Anthocyanin-Rich Maize Liu, Xiaoqing; Li, Suzhen; Yang, Wenzhu Plant and Cell Physiology, Vol. 59, Issue 10 https://doi.org/10.1093/pcp/pcy110	journal	June 2018
Characterization of the N-methoxyindole-3-carbinol (NI3C)-Induced Cell Cycle Arrest in Human Colon Cancer Cell Lines Neave, A. S. Toxicological Sciences, Vol. 83, Issue 1 https://doi.org/10.1093/toxsci/kfi008	journal	October 2004
Targeting Tryptophan Decarboxylase to Selected Subcellular Compartments of Tobacco Plants Affects Enzyme Stability and in Vivo Function and Leads to a Lesion-Mimic Phenotype Di Fiore, Stefano; Li, Qiurong; Leech, Mark James Plant Physiology, Vol. 129, Issue 3 https://doi.org/10.1104/pp.010889	journal	July 2002
Heterologous Expression of Methylketone Synthase1 and Methylketone Synthase2 Leads to Production of Methylketones and Myristic Acid in Transgenic Plants Yu, Geng; Pichersky, Eran Plant Physiology, Vol. 164, Issue 2 https://doi.org/10.1104/pp.113.228502	journal	January 2014
Morphogenic Regulators Baby boom and Wuschel Improve Monocot Transformation Lowe, Keith; Wu, Emily; Wang, Ning The Plant Cell, Vol. 28, Issue 9 https://doi.org/10.1105/tpc.16.00124	journal	September 2016
Identification of Plant Enhancers and Their Constituent Elements by STARR-seq in Tobacco Leaves Jores, Tobias; Tonnies, Jackson; Dorrity, Michael W. The Plant Cell, Vol. 32, Issue 7 https://doi.org/10.1105/tpc.20.00155	journal	May 2020
The aspirin story - from willow to wonder drug Desborough, Michael J. R.; Keeling, David M. British Journal of Haematology, Vol. 177, Issue 5 https://doi.org/10.1111/bjh.14520	journal	January 2017
Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure: XylT and FucT down-regulation in N. benthamiana Strasser, Richard; Stadlmann, Johannes; Schähs, Matthias Plant Biotechnology Journal, Vol. 6, Issue 4 https://doi.org/10.1111/j.1467-7652.2008.00330.x	journal	March 2008
Folate: A Functional Food Constituent Iyer, Ramya; Tomar, S. K. Journal of Food Science, Vol. 74, Issue 9 https://doi.org/10.1111/j.1750-3841.2009.01359.x	journal	November 2009
Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family Haun, William; Coffman, Andrew; Clasen, Benjamin M. Plant Biotechnology Journal, Vol. 12, Issue 7 https://doi.org/10.1111/pbi.12201	journal	May 2014
Golden bananas in the field: elevated fruit pro-vitamin A from the expression of a single banana transgene Paul, Jean-Yves; Khanna, Harjeet; Kleidon, Jennifer Plant Biotechnology Journal, Vol. 15, Issue 4 https://doi.org/10.1111/pbi.12650	journal	December 2016
Multiplexed CRISPR/Cas9-mediated metabolic engineering of γ-aminobutyric acid levels in Solanum lycopersicum Li, Rui; Li, Ran; Li, Xindi Plant Biotechnology Journal, Vol. 16, Issue 2 https://doi.org/10.1111/pbi.12781	journal	August 2017
Engineering of ‘Purple Embryo Maize’ with a multigene expression system derived from a bidirectional promoter and self-cleaving 2A peptides Liu, Xiaoqing; Yang, Wenzhu; Mu, Bona Plant Biotechnology Journal, Vol. 16, Issue 6 https://doi.org/10.1111/pbi.12883	journal	March 2018
Ectopic expression of ORANGE promotes carotenoid accumulation and fruit development in tomato Yazdani, Mohammad; Sun, Zhaoxia; Yuan, Hui Plant Biotechnology Journal, Vol. 17, Issue 1 https://doi.org/10.1111/pbi.12945	journal	May 2018
Biosynthesis of the anti‐diabetic metabolite montbretin A: glucosylation of the central intermediate mini‐MbA Irmisch, Sandra; Jancsik, Sharon; Yuen, Macaire M. S. The Plant Journal, Vol. 100, Issue 5 https://doi.org/10.1111/tpj.14493	journal	September 2019
Engineering the Provitamin A (-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm Ye, Xudong; Al-Babili, Salim; Kloti, Andreas Science, Vol. 287, Issue 5451, p. 303-305 https://doi.org/10.1126/science.287.5451.303	journal	January 2000
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle Caputi, Lorenzo; Franke, Jakob; Farrow, Scott C. Science, Vol. 360, Issue 6394 https://doi.org/10.1126/science.aat4100	journal	May 2018
Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field South, Paul F.; Cavanagh, Amanda P.; Liu, Helen W. Science, Vol. 363, Issue 6422 https://doi.org/10.1126/science.aat9077	journal	January 2019
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway Lee, Yu-Ru; Chen, Ming; Lee, Jonathan D. Science, Vol. 364, Issue 6441 https://doi.org/10.1126/science.aau0159	journal	May 2019
Exploring Uncharted Territories of Plant Specialized Metabolism in the Postgenomic Era Jacobowitz, Joseph R.; Weng, Jing-Ke Annual Review of Plant Biology, Vol. 71, Issue 1 https://doi.org/10.1146/annurev-arplant-081519-035634	journal	April 2020
Biology and Biochemistry of Glucosinolates Halkier, Barbara Ann; Gershenzon, Jonathan Annual Review of Plant Biology, Vol. 57, Issue 1 https://doi.org/10.1146/annurev.arplant.57.032905.105228	journal	June 2006
Metabolic Engineering of Yeast and Plants for the Production of the Biologically Active Hydroxystilbene, Resveratrol Jeandet, Philippe; Delaunois, Bertrand; Aziz, Aziz Journal of Biomedicine and Biotechnology, Vol. 2012 https://doi.org/10.1155/2012/579089	journal	January 2012
TransportTP: A two-phase classification approach for membrane transporter prediction and characterization Li, Haiquan; Benedito, Vagner A.; Udvardi, Michael K. BMC Bioinformatics, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2105-10-418	journal	January 2009
Tobacco seeds expressing feedback-insensitive cystathionine gamma-synthase exhibit elevated content of methionine and altered primary metabolic profile Matityahu, Ifat; Godo, Itamar; Hacham, Yael BMC Plant Biology, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2229-13-206	journal	December 2013
Screening for plant transporter function by expressing a normalized Arabidopsis full-length cDNA library in Xenopus oocytes Nour-Eldin, Hussam H.; Nørholm, Morten HH; Halkier, Barbara A. Plant Methods, Vol. 2, Issue 1 https://doi.org/10.1186/1746-4811-2-17	journal	October 2006
The generation of metabolic changes for the production of high-purity zeaxanthin mediated by CRISPR-Cas9 in Chlamydomonas reinhardtii Song, Inhwa; Kim, Jongrae; Baek, Kwangryul Microbial Cell Factories, Vol. 19, Issue 1 https://doi.org/10.1186/s12934-020-01480-4	journal	November 2020
The Global Hidden Hunger Indices and Maps: An Advocacy Tool for Action Muthayya, Sumithra; Rah, Jee Hyun; Sugimoto, Jonathan D. PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0067860	journal	June 2013
Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species Leisner, Courtney P.; Kamileen, Mohamed O.; Conway, Megan E. PLOS ONE, Vol. 12, Issue 6 https://doi.org/10.1371/journal.pone.0179417	journal	June 2017
Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana Crocoll, Christoph; Mirza, Nadia; Reichelt, Michael Frontiers in Bioengineering and Biotechnology, Vol. 4 https://doi.org/10.3389/fbioe.2016.00014	journal	February 2016
An Efficient Gene Excision System in Maize Wang, Ning; Arling, Maren; Hoerster, George Frontiers in Plant Science, Vol. 11 https://doi.org/10.3389/fpls.2020.01298	journal	September 2020
Transgenic Crops for Biofortification Malik, Kauser Abdulla; Maqbool, Asma Frontiers in Sustainable Food Systems, Vol. 4 https://doi.org/10.3389/fsufs.2020.571402	journal	November 2020
Glucosinolate Biosynthesis and the Glucosinolate–Myrosinase System in Plant Defense Chhajed, Shweta; Mostafa, Islam; He, Yan Agronomy, Vol. 10, Issue 11 https://doi.org/10.3390/agronomy10111786	journal	November 2020
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery Anand, Uttpal; Jacobo-Herrera, Nadia; Altemimi, Ammar Metabolites, Vol. 9, Issue 11 https://doi.org/10.3390/metabo9110258	journal	November 2019
Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Yagishita, Yoko; Fahey, Jed W.; Dinkova-Kostova, Albena T. Molecules, Vol. 24, Issue 19 https://doi.org/10.3390/molecules24193593	journal	October 2019

Similar Records

Editorial: Proceedings of ICPSBBB 2018 - 2nd International Conference on Plant Synthetic Biology, Bioengineering and Biotechnology

Journal Article · 2020 · Frontiers in Plant Science · OSTI ID:1725809

Scheller, Henrik Vibe; Patron, Nicola; Jensen, Poul Erik

Biotechnological advances in algae-based foods: applications in nutrition and microbiome health

Journal Article · 2025 · Current Opinion in Biotechnology · OSTI ID:2583297

Yu, Sora; Yoshikuni, Yasuo

A robust gene-stacking method utilizing yeast assembly for plant synthetic biology

Journal Article · 2016 · Nature Communications · OSTI ID:1377550

Shih, Patrick M.; Vuu, Khanh; Mansoori, Nasim; +5 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
human health
natural products
nutraceuticals
nutrition
pharmaceuticals
plant synthetic biology

Title: Utilizing Plant Synthetic Biology to Improve Human Health and Wellness

Citation Formats

References (109)

Similar Records

Related Subjects