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Title: Advances in engineering microbial biosynthesis of aromatic compounds and related compounds

Journal Article · · Bioresources and Bioprocessing

Abstract Aromatic compounds have broad applications and have been the target of biosynthetic processes for several decades. New biomolecular engineering strategies have been applied to improve production of aromatic compounds in recent years, some of which are expected to set the stage for the next wave of innovations. Here, we will briefly complement existing reviews on microbial production of aromatic compounds by focusing on a few recent trends where considerable work has been performed in the last 5 years. The trends we highlight are pathway modularization and compartmentalization, microbial co-culturing, non-traditional host engineering, aromatic polymer feedstock utilization, engineered ring cleavage, aldehyde stabilization, and biosynthesis of non-standard amino acids. Throughout this review article, we will also touch on unmet opportunities that future research could address.

Research Organization:
Univ. of Delaware, Newark, DE (United States)
Sponsoring Organization:
USDOE Office of Science (SC); USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
SC0021166
OSTI ID:
1822461
Journal Information:
Bioresources and Bioprocessing, Journal Name: Bioresources and Bioprocessing Journal Issue: 1 Vol. 8; ISSN 2197-4365
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
Germany
Language:
English

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