Title: A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers

Abstract

Understanding the role of nonequilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and nonequilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle cross-linked by two competing types of actin-binding proteins [S. L. Freedman et al., Proc. Natl. Acad. Sci. U.S.A. 116, 16192–16197 (2019)], we construct a minimal model for such a system and show that the dynamics of a growing actin bundle are subject to a set of thermodynamic constraints that relate its nonequilibrium driving, morphology, and molecular fluxes. The thermodynamic constraints reveal the importance of correlations between these molecular fluxes and offer a route to estimating microscopic driving forces from microscopy experiments.

Authors:

Qiu, Yuqing  ^[1];

• Search DOE PAGES for author "Qiu, Yuqing"
• Search DOE PAGES for ORCID "0000-0002-0745-3155"

Nguyen, Michael  ^[1];

• Search DOE PAGES for author "Nguyen, Michael"
• Search DOE PAGES for ORCID "0000-0002-3267-5462"

Hocky, Glen M.  ^[2];

• Search DOE PAGES for author "Hocky, Glen M."
• Search DOE PAGES for ORCID "0000-0002-5637-0698"

Dinner, Aaron R.  ^[1];

• Search DOE PAGES for author "Dinner, Aaron R."
• Search DOE PAGES for ORCID "0000-0001-8328-6427"

Vaikuntanathan, Suriyanarayanan ^[1]

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+ Show Author Affiliations

1. James Franck Institute, University of Chicago, Chicago, IL 60637,, Department of Chemistry, University of Chicago, Chicago, IL 60637,
2. Department of Chemistry, New York University, New York, NY 10003

Publication Date:

Mon Sep 13 00:00:00 EDT 2021

Research Org.:

Univ. of Chicago, IL (United States)

Sponsoring Org.:

USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:

1821015

Alternate Identifier(s):

OSTI ID: 1853394

Grant/Contract Number:  

SC0019765; R35 GM138312.; R35 GM136381

Resource Type:

Published Article

Journal Name:

Proceedings of the National Academy of Sciences of the United States of America

Additional Journal Information:

Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 118 Journal Issue: 38; Journal ID: ISSN 0027-8424

Publisher:

Proceedings of the National Academy of Sciences

Country of Publication:

United States

Language:

English

Subject:

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Science & Technology - Other Topics; fluctuation–response relations; microscopic nonequilibrium driving; stochastic thermodynamics; actin bundling and growth