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Title: Conformational control via sequence for a heteropeptoid in water: coupled NMR and Rosetta modelling

Journal Article · · ChemComm
DOI: https://doi.org/10.1039/D1CC01992A · OSTI ID:1819391
ORCiD logo [1]; ORCiD logo [2];  [3];  [1]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [3]; ORCiD logo [3]; ORCiD logo [5]
  1. Center for Integrated Nanotechnologies, (CINT), Los Alamos National Laboratory, Los Alamos, NM 87545, USA
  2. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
  3. Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
  4. Materials Science and Technology Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
  5. Center for Materials Interfaces in Research and Applications, Northern Arizona University, Flagstaff, Arizona 86011, USA, Department of Applied Physics and Materials Science, Northern Arizona University, Flagstaff, Arizona 86011, USA

Structured water-soluble and hetero-oligomeric peptoids: the importance of peptoid-specific backbone restrictions.

Sponsoring Organization:
USDOE
OSTI ID:
1819391
Journal Information:
ChemComm, Journal Name: ChemComm Journal Issue: 77 Vol. 57; ISSN CHCOFS; ISSN 1359-7345
Publisher:
Royal Society of Chemistry (RSC)Copyright Statement
Country of Publication:
United Kingdom
Language:
English

References (44)

Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications journal September 2019
Stabilising Peptoid Helices Using Non‐Chiral Fluoroalkyl Monomers journal August 2018
A Rotamer Library to Enable Modeling and Design of Peptoid Foldamers journal June 2014
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis journal December 1992
Peptoids and Polypeptoids at the Frontier of Supra- and Macromolecular Engineering journal December 2015
Helical Peptoid Mimics of Magainin-2 Amide journal October 2003
Helicity of Peptoid Ions in the Gas Phase journal January 2020
Expedient Synthesis and Design Strategies for New Peptoid Construction journal April 2005
Peptoid Oligomers with α-Chiral, Aromatic Side Chains:  Sequence Requirements for the Formation of Stable Peptoid Helices journal July 2001
Cooperative Intramolecular Hydrogen Bonding Strongly Enforces cis -Peptoid Folding journal November 2019
Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates? journal July 2016
Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure journal April 1998
Global analysis of protein folding using massively parallel design, synthesis, and testing journal July 2017
NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains journal April 1998
Equilibrium Denaturation and Preferential Interactions of an RNA Tetraloop with Urea journal January 2017
Peptoid Polymers: A Highly Designable Bioinspired Material journal May 2013
Microwave-Assisted Solid-Phase Synthesis of Peptoids journal November 2002
Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds journal May 2015
Water soluble hydrophobic peptoids via a minor backbone modification journal January 2018
Unconstrained peptoid tetramer exhibits a predominant conformation in aqueous solution journal March 2019
An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network journal March 2014
Per-Residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions journal January 2020
Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains journal December 2001
Homogeneous and Robust Polyproline Type I Helices from Peptoids with Nonaromatic α-Chiral Side Chains journal September 2017
Chiral N-substituted glycines can form stable helical conformations journal December 1997
Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer journal October 2018
A Threaded Loop Conformation Adopted by a Family of Peptoid Nonamers journal February 2006
Biomimetic peptoid oligomers as dual-action antifreeze agents journal November 2012
Peptoids: a modular approach to drug discovery. journal October 1992
Controlled Microwave Heating in Modern Organic Synthesis journal November 2004
Toward the Synthesis of Artificial Proteins journal May 2002
Peptoid conformational free energy landscapes from implicit-solvent molecular simulations in AMBER journal December 2010
Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design journal July 2013
Local and Tunable n→π* Interactions Regulate Amide Isomerism in the Peptoid Backbone journal July 2007
Self-Association of Water-Soluble Peptoids Comprising ( S )- N -1-(Naphthylethyl)glycine Residues journal September 2013
Weak backbone CH ⋯ OC and side chain tBu ⋯ tBu London interactions help promote helix folding of achiral NtBu peptoids journal January 2016
Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N -1-Naphthylethyl Side Chains journal October 2011
Structural and Spectroscopic Studies of Peptoid Oligomers with α-Chiral Aliphatic Side Chains journal November 2003
Peptoid origins journal December 2010
Strengthening Peptoid Helicity through Sequence Site-Specific Positioning of Amide cis -Inducing Nt Bu Monomers journal December 2019
Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure journal February 2019
A Preliminary Survey of the Peptoid Folding Landscape journal November 2009
Peptoid helicity modulation: precise control of peptoid secondary structures via position-specific placement of chiral monomers journal January 2014
Rosetta comparative modeling for library design: Engineering alternative inducer specificity in a transcription factor: A Comparative Approach for Protein Design journal May 2015