Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness

Sinha, Nairiti J.; Shi, Yi; Tang, Yao; Kloxin, Christopher J.; Saven, Jeffery G.; Faraone, Antonio; Jensen, Grethe V.; Pochan, Darrin J.

doi:10.1103/physrevmaterials.5.095601

Title: Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness

Journal Article · 06 September 2021 · Physical Review Materials

DOI: https://doi.org/10.1103/physrevmaterials.5.095601 · OSTI ID:1819311

Sinha, Nairiti J. ^[1]; Shi, Yi ^[2];

^[2]; Kloxin, Christopher J. ^[2];

^[3]; Faraone, Antonio ^[4];

^[5];

^[2]

Univ. of Delaware, Newark, DE (United States); National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States); University of Delaware
Univ. of Delaware, Newark, DE (United States)
Univ. of Pennsylvania, Philadelphia, PA (United States)
National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States)
Univ. of Delaware, Newark, DE (United States); National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States); Danish Technological Institute, Tåstrup (Denmark)

Here, polymers assembled using computationally designed coiled coil bundlemers display tunable stiffness via control of interbundlemer covalent connectivity as confirmed using small-angle neutron scattering. Neutron spin echo spectroscopy reveals that rigid rod polymers show a decay rate Γ~Q² (Q is the scattering vector) expected of straight cylinders. Semirigid polymers assembled using bundlemers linked via 4-armed organic linker show flexible segmental dynamics at mid-Q and Γ~Q² behavior at high Q. The results give insight into linker flexibility-dependent interbundlemer dynamics in the hybrid polymers.

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Research Organization:: National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States); Univ. of Delaware, Newark, DE (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: SC0019282; SC0019355

OSTI ID:: 1819311

Journal Information:: Physical Review Materials, Journal Name: Physical Review Materials Journal Issue: 9 Vol. 5; ISSN 2475-9953

Publisher:: American Physical Society (APS)Copyright Statement

Country of Publication:: United States

Language:: English

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Title: Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness

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