Influence of trace erythromycin and erythromycin-H2O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs)

Fan, Caian; Lee, Patrick K.  H.; Ng, Wun Jern; Alvarez-Cohen, Lisa; Brodie, Eoin L.; Andersen, Gary L.; He, Jianzhong

doi:10.1007/s00253-009-2201-7

Title: Influence of trace erythromycin and erythromycin-H₂O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs)

Journal Article · 01 September 2009 · Applied Microbiology and Biotechnology

DOI: https://doi.org/10.1007/s00253-009-2201-7 · OSTI ID:1816018

Fan, Caian ^[1]; Lee, Patrick K. H. ^[2]; Ng, Wun Jern ^[3]; Alvarez-Cohen, Lisa ^[4]; Brodie, Eoin L. ^[5]; Andersen, Gary L. ^[5]; He, Jianzhong ^[3]

National Univ. of Singapore (Singapore). Division of Environmental Science and Engineering; OSTI
Univ. of California, Berkeley, CA (United States). Dept. of Civil and Environmental Engineering
National Univ. of Singapore (Singapore). Division of Environmental Science and Engineering
Univ. of California, Berkeley, CA (United States). Dept. of Civil and Environmental Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Science Division
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Science Division

Three sequencing batch reactors (SBRs) were operated in parallel to study the effects of trace erythromycin (ERY) and ERY-H₂O on the treatment of a synthetic wastewater. Through monitoring (1) daily effluents and (2) concentrations of nitrogen (N) and phosphorous (P) in certain batch cycles of the three reactors operated from transient to steady states, the removal of carbon, N, and P was affected negligibly by ERY (100µg/L) or ERY-H₂O (50µg/L) when compared with the control reactor. However, through analyzing microbial communities of the three steady state SBRs on high-density microarrays (PhyloChip), ERY, and ERY-H₂O had pronounced effects on the community composition of bacteria related to N and P removal, leading to diversity loss and abundance change. The above observations indicated that resistant bacteria were selected upon exposure to ERY or ERY-H₂O. Short-term batch experiments further proved the resistance and demonstrated that ammonium oxidation (56–95%) was inhibited more significantly than nitrite oxidation (18–61%) in the presence of ERY (100, 400, or 800µg/L). Therefore, the presence of ERY or ERY-H₂O (at µg/L levels) shifted the microbial community and selected resistant bacteria, which may account for the negligible influence of the antibiotic ERY or its derivative ERY-H₂O (at µg/L levels) on carbon, N, and P removal in the SBRs.

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Research Organization:: Univ. of California, Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1816018

Journal Information:: Applied Microbiology and Biotechnology, Journal Name: Applied Microbiology and Biotechnology Journal Issue: 1 Vol. 85; ISSN 0175-7598

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Influence of tetracycline on the microbial community composition and activity of nitrifying biofilms Matos, Maria; Pereira, Maria A.; Parpot, Pier Chemosphere, Vol. 117 https://doi.org/10.1016/j.chemosphere.2014.06.094	journal	December 2014
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59 BASIC BIOLOGICAL SCIENCES
Antibiotics
Dehydrated erythromycin (ERY-H2O)
Erythromycin (ERY)
Nutrients removal
Sequencing batch reactors (SBRs)

Title: Influence of trace erythromycin and erythromycin-H2O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs)

Citation Formats

References (47)

Cited By (4)

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Related Subjects

Title: Influence of trace erythromycin and erythromycin-H₂O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs)