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Title: The interaction of Thrombospondins with extracellular matrix proteins

Journal Article · · Journal of Cell Communication and Signaling
 [1];  [2]
  1. Argonne National Lab. (ANL), Argonne, IL (United States). The Midwest Center for Structural Genomics and Structural Biology Center; OSTI
  2. Beth Israel Deaconess Medical Center, Boston, MA (United States). Dept. of Pathology. Division of Experimental Pathology; Harvard Medical School, Boston, MA (United States)
+ Show Author Affiliations

The thrombospondins (TSPs) are a family of five matricellular proteins that appear to function as adapter molecules to guide extracellular matrix synthesis and tissue remodeling in a variety of normal and disease settings. Various TSPs have been shown to bind to fibronectin, laminin, matrilins, collagens and other extracellular matrix (ECM) proteins. The importance of TSP-1 in this context is underscored by the fact that it is rapidly deposited at the sites of tissue damage by platelets. An association of TSPs with collagens has been known for over 25 years. The observation that the disruption of the TSP-2 gene in mice leads to collagen fibril abnormalities provided important in vivo evidence that these interactions are physiologically important. Recent biochemical studies have shown that TSP-5 promotes collagen fibril assembly and structural studies suggest that TSPs may interact with collagens through a highly conserved potential metal ion dependent adhesion site (MIDAS). These interactions are critical for normal tissue homeostasis, tumor progression and the etiology of skeletal dysplasias.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1815869
Journal Information:
Journal of Cell Communication and Signaling, Journal Name: Journal of Cell Communication and Signaling Journal Issue: 3-4 Vol. 3; ISSN 1873-9601
Publisher:
Springer NatureCopyright Statement
Country of Publication:
United States
Language:
English

References (163)

In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo journal March 1997
Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1 journal October 1997
Colocalization of thrombospondin and syndecan during murine development journal April 1992
Differential expression of thrombospondin 1, 2, and 3 during murine development journal May 1993
Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations journal April 2002
Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1) journal January 2006
Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1 journal January 2007
Cellular and molecular mechanisms of fibrosis journal January 2008
Functional Changes in the Conformation of Thrombospondin-1 during Complexation with Fibronectin or Heparin journal May 1999
Thrombospondins: from structure to therapeutics: Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations journal January 2008
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen journal November 1982
The thrombospondin type 1 repeat superfamily journal June 2004
The N-terminus of thrombospondin: the domain stands apart journal June 2004
Tumor progression: the effects of thrombospondin-1 and -2 journal June 2004
The role of thrombospondins 1 and 2 in the regulation of cell–matrix interactions, collagen fibril formation, and the response to injury journal June 2004
Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retina journal April 2007
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion journal February 2008
COMP mutations, chondrocyte function and cartilage matrix journal January 2005
The Lack of Thrombospondin-1 (TSP1) Dictates the Course of Wound Healing in Double-TSP1/TSP2-Null Mice journal September 2002
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation journal January 2003
The cell biology of thrombospondin-1 journal December 2000
A recombinant NH2-terminal heparin-binding domain of the adhesive glycoprotein, thrombospondin-1, promotes endothelial tube formation and cell survival: a possible role for syndecan-4 proteoglycan journal June 2002
Matrix–matrix interaction of cartilage oligomeric matrix protein and fibronectin journal August 2002
Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudochondroplasia musculoskeletal tissues journal August 1998
Matricellular proteins: extracellular modulators of cell function journal October 2002
Expression and mutagenesis of thrombospondin journal February 1992
Thrombospondin is a substrate for blood coagulation factor XIIIa journal September 1986
Structure of the calcium-rich signature domain of human thrombospondin-2 journal September 2005
Characterization of the antiplasmin activity of human thrombospondin-1 in solution journal February 1993
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene journal November 1999
Effects of Sized Heparin Oligosaccharide on the Interactions of Chinese Hamster Ovary Cell with Thrombospondin journal April 1992
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin  L 2 journal February 2005
Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis journal February 2008
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor journal October 2001
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. journal September 1990
Cartilage Oligomeric Matrix Protein Shows High Affinity Zinc-dependent Interaction with Triple Helical Collagen journal August 1998
Interaction of Recombinant Procollagen and Properdin Modules of Thrombospondin-1 with Heparin and Fibrinogen/Fibrin journal January 1999
Thrombospondin-4 Binds Specifically to Both Collagenous and Non-collagenous Extracellular Matrix Proteins via Its C-terminal Domains journal November 2000
Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2 journal March 2001
Cartilage Oligomeric Matrix Protein Interacts with Type IX Collagen, and Disruptions to These Interactions Identify a Pathogenetic Mechanism in a Bone Dysplasia Family journal February 2001
Mutations in Cartilage Oligomeric Matrix Protein Causing Pseudoachondroplasia and Multiple Epiphyseal Dysplasia Affect Binding of Calcium and Collagen I, II, and IX journal March 2001
Molecular Interactions That Confer Latency to Transforming Growth Factor-β journal September 2004
Disruption of Extracellular Matrix Structure May Cause Pseudoachondroplasia Phenotypes in the Absence of Impaired Cartilage Oligomeric Matrix Protein Secretion journal October 2006
Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain journal February 2008
COMP Acts as a Catalyst in Collagen Fibrillogenesis journal October 2007
Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy. journal May 1987
Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143] journal August 1993
Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. journal November 1995
Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis journal January 1998
Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. journal February 1984
Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1. journal April 1994
Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions journal October 2002
Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution journal December 2006
Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding journal January 1999
Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1 journal February 2004
The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding journal March 2009
Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts journal January 2008
Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head journal July 2005
Altered Integration of Matrilin-3 into Cartilage Extracellular Matrix in the Absence of Collagen IX journal December 2005
Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to Ischemia journal December 2007
Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts journal June 2005
Complex formation of platelet thrombospondin with fibrinogen. journal September 1982
Megakaryocytes require thrombospondin-2 for normal platelet formation and function journal May 2003
Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region journal March 2008
Enhanced Angiogenesis and Reduced Contraction in Thrombospondin-2–null Wounds Is Associated With Increased Levels of Matrix Metalloproteinases-2 and −9, and Soluble VEGF journal December 2008
The Role of the Thrombospondins in Healing Myocardial Infarcts journal January 2007
Unique Matrix Structure in the Rough Endoplasmic Reticulum Cisternae of Pseudoachondroplasia Chondrocytes journal January 2007
Skeletal Abnormalities in Mice Lacking Extracellular Matrix Proteins, Thrombospondin-1, Thrombospondin-3, Thrombospondin-5, and Type IX Collagen journal June 2008
In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo journal March 1997
Thrombospondins in earlyXenopus embryos: Dynamic patterns of expression suggest diverse roles in nervous system, notochord, and muscle development journal April 1998
Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1 journal October 1997
Colocalization of thrombospondin and syndecan during murine development journal April 1992
Differential expression of thrombospondin 1, 2, and 3 during murine development journal May 1993
Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations journal April 2002
Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1) journal January 2006
Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1 journal January 2007
Cellular and molecular mechanisms of fibrosis journal January 2008
Specificities of Heparin-binding Sites from the Amino-Terminus and Type 1 Repeats of Thrombospondin-1 journal February 2000
Functional Changes in the Conformation of Thrombospondin-1 during Complexation with Fibronectin or Heparin journal May 1999
Thrombospondins: from structure to therapeutics: Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations journal January 2008
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen journal November 1982
The Lack of Thrombospondin-1 (TSP1) Dictates the Course of Wound Healing in Double-TSP1/TSP2-Null Mice journal September 2002
Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. journal December 1978
Effects of thrombospondin on fibrin polymerization and structure. journal January 1986
Thrombospondin 3 is a developmentally regulated heparin binding protein. journal January 1994
Thrombospondin 1 is a tight-binding competitive inhibitor of neutrophil cathepsin G. Determination of the kinetic mechanism of inhibition and localization of cathepsin G binding to the thrombospondin 1 type 3 repeats. journal October 1993
Structural Basis of Collagen Recognition by Integrin α2β1 journal March 2000
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation journal January 2003
The cell biology of thrombospondin-1 journal December 2000
A recombinant NH2-terminal heparin-binding domain of the adhesive glycoprotein, thrombospondin-1, promotes endothelial tube formation and cell survival: a possible role for syndecan-4 proteoglycan journal June 2002
Matrix–matrix interaction of cartilage oligomeric matrix protein and fibronectin journal August 2002
Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudochondroplasia musculoskeletal tissues journal August 1998
Matricellular proteins: extracellular modulators of cell function journal October 2002
Coming to grips with integrin binding to ligands journal October 2002
The thrombospondin type 1 repeat superfamily journal June 2004
The N-terminus of thrombospondin: the domain stands apart journal June 2004
Tumor progression: the effects of thrombospondin-1 and -2 journal June 2004
The role of thrombospondins 1 and 2 in the regulation of cell–matrix interactions, collagen fibril formation, and the response to injury journal June 2004
Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retina journal April 2007
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion journal February 2008
COMP mutations, chondrocyte function and cartilage matrix journal January 2005
The Structures of the Thrombospondin-1 N-Terminal Domain and Its Complex with a Synthetic Pentameric Heparin journal January 2006
Expression and mutagenesis of thrombospondin journal February 1992
Thrombospondin is a substrate for blood coagulation factor XIIIa journal September 1986
Structure of the calcium-rich signature domain of human thrombospondin-2 journal September 2005
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats journal March 2004
Characterization of the antiplasmin activity of human thrombospondin-1 in solution journal February 1993
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene journal November 1999
Thrombospondin 1 as an Enzyme Inhibitor journal January 1994
Effects of Sized Heparin Oligosaccharide on the Interactions of Chinese Hamster Ovary Cell with Thrombospondin journal April 1992
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin  L 2 journal February 2005
Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis journal February 2008
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor journal October 2001
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. journal September 1990
Thrombospondin 3 Is a Pentameric Molecule Held Together by Interchain Disulfide Linkage Involving Two Cysteine Residues journal May 1995
Cartilage Oligomeric Matrix Protein Shows High Affinity Zinc-dependent Interaction with Triple Helical Collagen journal August 1998
Interaction of Recombinant Procollagen and Properdin Modules of Thrombospondin-1 with Heparin and Fibrinogen/Fibrin journal January 1999
Thrombospondin-4 Binds Specifically to Both Collagenous and Non-collagenous Extracellular Matrix Proteins via Its C-terminal Domains journal November 2000
Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2 journal March 2001
Cartilage Oligomeric Matrix Protein Interacts with Type IX Collagen, and Disruptions to These Interactions Identify a Pathogenetic Mechanism in a Bone Dysplasia Family journal February 2001
Mutations in Cartilage Oligomeric Matrix Protein Causing Pseudoachondroplasia and Multiple Epiphyseal Dysplasia Affect Binding of Calcium and Collagen I, II, and IX journal March 2001
Characterization of Recombinant Amino-terminal NC4 Domain of Human Collagen IX journal June 2004
Interactions between the Cartilage Oligomeric Matrix Protein and Matrilins journal June 2004
The Tryptophan-rich Motifs of the Thrombospondin Type 1 Repeats Bind VLAL Motifs in the Latent Transforming Growth Factor-β Complex journal November 2004
Molecular Interactions That Confer Latency to Transforming Growth Factor-β journal September 2004
Disruption of Extracellular Matrix Structure May Cause Pseudoachondroplasia Phenotypes in the Absence of Impaired Cartilage Oligomeric Matrix Protein Secretion journal October 2006
Interaction of Cartilage Oligomeric Matrix Protein/Thrombospondin 5 with Aggrecan journal August 2007
Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain journal February 2008
COMP Acts as a Catalyst in Collagen Fibrillogenesis journal October 2007
Distinct Roles of β1 Metal Ion-dependent Adhesion Site (MIDAS), Adjacent to MIDAS (ADMIDAS), and Ligand-associated Metal-binding Site (LIMBS) Cation-binding Sites in Ligand Recognition by Integrin α2β1 journal November 2008
Structural Insights into the Interactions between Platelet Receptors and Fibrillar Collagen journal July 2009
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. journal November 1986
Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy. journal May 1987
Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143] journal August 1993
Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. journal November 1995
Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis journal January 1998
Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. journal February 1984
Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1. journal April 1994
Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions journal October 2002
Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution journal December 2006
Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding journal January 1999
Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1 journal February 2004
The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding journal March 2009
Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts journal January 2008
Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head journal July 2005
Altered Integration of Matrilin-3 into Cartilage Extracellular Matrix in the Absence of Collagen IX journal December 2005
Structural Basis of Integrin Regulation and Signaling journal April 2007
Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to Ischemia journal December 2007
Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts journal June 2005
Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways journal August 2002
Complex formation of platelet thrombospondin with fibrinogen. journal September 1982
Thrombospondin-1 is Induced in Rat Myocardial Infarction and Its Induction is Accelerated by Ischemia/Reperfusion journal October 2005
Megakaryocytes require thrombospondin-2 for normal platelet formation and function journal May 2003
Thiol-Disulfide Isomerization in Thrombospondin: Effects of Conformation and Protein Disulfide Isomerase journal May 1997
Structure of the Calcium-Rich Signature Domain of Human Thrombospondin-2. journal November 2005
Procollagen trafficking, processing and fibrillogenesis journal April 2005
Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region journal March 2008
Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells journal November 2006
Enhanced Angiogenesis and Reduced Contraction in Thrombospondin-2–null Wounds Is Associated With Increased Levels of Matrix Metalloproteinases-2 and −9, and Soluble VEGF journal December 2008
The Role of the Thrombospondins in Healing Myocardial Infarcts journal January 2007
Unique Matrix Structure in the Rough Endoplasmic Reticulum Cisternae of Pseudoachondroplasia Chondrocytes journal January 2007
Skeletal Abnormalities in Mice Lacking Extracellular Matrix Proteins, Thrombospondin-1, Thrombospondin-3, Thrombospondin-5, and Type IX Collagen journal June 2008
Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth text January 1995

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59 BASIC BIOLOGICAL SCIENCES
Cartilage oligomeric matrix protein
Extracellular matrix
Matricellular
Thrombospondin