Mediated electrochemistry for redox-based biological targeting: entangling sensing and actuation for maximizing information transfer

Motabar, Dana; Li, Jinyang; Payne, Gregory F.; Bentley, William E.

doi:10.1016/j.copbio.2021.07.017

Title: Mediated electrochemistry for redox-based biological targeting: entangling sensing and actuation for maximizing information transfer

Journal Article · Thu Aug 05 00:00:00 UTC 2021 · Current Opinion in Biotechnology

DOI: https://doi.org/10.1016/j.copbio.2021.07.017 · OSTI ID:1814446

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Univ. of Maryland, College Park, MD (United States); University of Maryland, College Park
Univ. of Maryland, College Park, MD (United States)

Biology and electronics are both expert at receiving, analyzing, and responding to information, yet they use entirely different information processing paradigms. Biology processes information using networks that are intrinsically molecular while electronics process information through circuits that control the flow of electrons. There is great interest in coupling the molecular logic of biology with the electronic logic of technology, and we suggest that redox (reduction-oxidation) is a uniquely-suited modality for interfacing biology with electronics. Specifically, redox is a native biological modality and is accessible to electronics through electrodes. Here, we summarize recent advances in mediated electrochemistry to direct information transfer into biological systems intentionally altering function, exposing it for more advanced interpretation, which can dramatically expand the biotechnological toolbox.

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Research Organization:: Univ. of Maryland, College Park, MD (United States)

Sponsoring Organization:: Defense Threat Reduction Agency (DTRA); National Science Foundation (NSF); USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1814446

Journal Information:: Current Opinion in Biotechnology, Journal Name: Current Opinion in Biotechnology Vol. 71; ISSN 0958-1669

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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