Title: Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain

Journal Article · · Journal of Virology
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  1. Laboratory of Pharmaceutical Biotechnology, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
  2. Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California Los Angeles, Los Angeles, California, USA
  3. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), IQUIBICEN, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Ciudad Universitaria, Buenos Aires, Argentina, IQUIBICEN, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Ciudad Universitaria, Buenos Aires, Argentina
  4. Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA
  5. Department of Biological Chemistry and Department of Chemistry and Biochemistry, University of California Los Angeles, Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, USA
  6. Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA, Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA
  7. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), IQUIBICEN, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Ciudad Universitaria, Buenos Aires, Argentina
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Pathogenic clade B NWMs cause grave infectious diseases, the South American hemorrhagic fevers. Their etiological agents are Junin (JUNV), Guanarito (GTOV), Sabiá (SABV), Machupo (MACV), Chapare (CHAV), and a new Sabiá-like (SABV-L) virus recently identified in Brazil.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NIH-NIGMS; NSF; Ruth L. Kirschstein NRSA; USDOE; USDOE Office of Science (SC)
Grant/Contract Number:
FC02-02ER63421
OSTI ID:
1812763
Journal Information:
Journal of Virology, Journal Name: Journal of Virology Journal Issue: 17 Vol. 95; ISSN 0022-538X
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
Junin
Machupo
Sabiá-like
X-ray crystallography
antiviral agents
electron microscopy
mammarenavirus
monoclonal antibodies
transferrin receptor