Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Sims, Amy C.; Mitchell, Hugh D.; Gralinski, Lisa E.; Kyle, Jennifer E.; Burnum-Johnson, Kristin E.; Lam, Mariam; Fulcher, M. Leslie; West, Ande; Smith, Richard D.; Randell, Scott H.; Metz, Thomas O.; Sheahan, Timothy P.; Waters, Katrina M.; Baric, Ralph S.; Moscona, ed., Anne

doi:10.1128/mBio.01572-21

Title: Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Journal Article · 31 August 2021 · mBio (Online)

DOI: https://doi.org/10.1128/mBio.01572-21 · OSTI ID:1812554

^[1]; Mitchell, Hugh D. ^[2]; Gralinski, Lisa E. ^[1]; Kyle, Jennifer E. ^[2];

^[2]; Lam, Mariam ^[3]; Fulcher, M. Leslie ^[3]; West, Ande ^[1]; Smith, Richard D. ^[2]; Randell, Scott H. ^[4];

^[2]; Sheahan, Timothy P. ^[1]; Waters, Katrina M. ^[2];

^[1]; Moscona, ed., Anne

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Biological Sciences Division, Pacific Northwest National Laboratories, Richland, Washington, USA
Marsico Lung Institute Tissue Procurement and Cell Culture Core, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Marsico Lung Institute Tissue Procurement and Cell Culture Core, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe atypical pneumonia in infected individuals, but the underlying mechanisms of pathogenesis remain unknown. While much has been learned from the few reported autopsy cases, an in-depth understanding of the cells targeted by MERS-CoV in the human lung and their relative contribution to disease outcomes is needed.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1812554

Report Number(s):: PNNL-SA--162254; e01572-21

Journal Information:: mBio (Online), Journal Name: mBio (Online) Journal Issue: 4 Vol. 12; ISSN 2150-7511

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
MERS-CoV
acute lung injury
apoptosis
fibroblasts
microvascular endothelial cells
primary human lung cells
unfolded protein response

Title: Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

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