A Review of Coccidioides Research, Outstanding Questions in the Field, and Contributions by Women Scientists

Gorris, Morgan E.; Caballero Van Dyke, Marley C.; Carey, Adrienne; Hamm, Paris S.; Mead, Heather L.; Uehling, Jessie K.

doi:10.1007/s40588-021-00173-9

Title: A Review of Coccidioides Research, Outstanding Questions in the Field, and Contributions by Women Scientists

Journal Article · 02 August 2021 · Current Clinical Microbiology Reports

DOI: https://doi.org/10.1007/s40588-021-00173-9 · OSTI ID:1811586

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Abstract Purpose of Review Coccidioidomycosis is an infectious disease that gained clinical significance in the early 20th century. Many of the foundational contributions to coccidioidomycosis research, including the discovery of the fungal disease agent, Coccidioides spp., were made by women. We review recent progress in Coccidioides research and big questions remaining in the field, while highlighting some of the contributions from women. Recent Findings New molecular-based techniques provide a promising method for detecting Coccidioides, which can help determine the dominate reservoir host and ideal environmental conditions for growth. Genetic and genomic analyses have allowed an understanding of population structure, species level diversity, and evolutionary histories. We present a current, comprehensive genome list, where women contributed many of these entries. Several efforts to develop a coccidioidomycosis vaccine are underway. Summary Women continue to pioneer research on Coccidioides, including the relationships between the fungi and the environment, genetics, and clinical observations. Significant questions remain in the field of Coccidioides, including the main host reservoir, the relationships between genotypic and phenotypic variation, and the underlying cause for chronic clinical coccidioidomycosis cases.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: LDRD; USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1811586

Report Number(s):: LA-UR--21-23354; PII: 173

Journal Information:: Current Clinical Microbiology Reports, Journal Name: Current Clinical Microbiology Reports Journal Issue: 3 Vol. 8; ISSN 2196-5471

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: Germany

Language:: English

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The Isolation of Haplosporangium parvum n. sp. and Coccidioides immitis from Wild Rodents. Their Relationship to Coccidioidomycosis Emmons, C. W.; Ashburn, L. L. Public Health Reports (1896-1970), Vol. 57, Issue 46 https://doi.org/10.2307/4584276	journal	January 1942
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Coccidioidomycosis and Other Systemic Mycoses of Marine Mammals Stranding Along the Central California, usa Coast: 1998–2012 Huckabone, Sara E.; Gulland, Frances M. D.; Johnson, Suzanne M. Journal of Wildlife Diseases, Vol. 51, Issue 2 https://doi.org/10.7589/2014-06-143	journal	April 2015

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