Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response

Atanasio, Amanda; Franklin, Matthew C.; Kamat, Vishal; Hernandez, Annabel Romero; Badithe, Ashok; Ben, Li-Hong; Jones, Jennifer; Bautista, Joannie; Yancopoulos, George D.; Olson, William; Murphy, Andrew J.; Sleeman, Matthew A.; Orengo, Jamie M.

doi:10.1016/j.jaci.2021.05.038

Title: Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response

Journal Article · 01 January 2022 · Journal of Allergy and Clinical Immunology

DOI: https://doi.org/10.1016/j.jaci.2021.05.038 · OSTI ID:1807639

Atanasio, Amanda; Franklin, Matthew C.; Kamat, Vishal; Hernandez, Annabel Romero; Badithe, Ashok; Ben, Li-Hong; Jones, Jennifer; Bautista, Joannie; Yancopoulos, George D.; Olson, William; Murphy, Andrew J.; Sleeman, Matthew A.; Orengo, Jamie M.

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1807639

Journal Information:: Journal of Allergy and Clinical Immunology, Journal Name: Journal of Allergy and Clinical Immunology Journal Issue: 1 Vol. 149; ISSN 0091-6749

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (61)

The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. Breiteneder, H.; Pettenburger, K.; Bito, A. The EMBO Journal, Vol. 8, Issue 7 https://doi.org/10.1002/j.1460-2075.1989.tb03597.x	journal	July 1989
Proteomic profiling of birch ( Betula verrucosa ) pollen extracts from different origins Erler, Anja; Hawranek, Thomas; Krückemeier, Leif PROTEOMICS, Vol. 11, Issue 8 https://doi.org/10.1002/pmic.201000624	journal	February 2011
Climate change effect on Betula (birch) and Quercus (oak) pollen seasons in the United States Zhang, Yong; Bielory, Leonard; Georgopoulos, Panos G. International Journal of Biometeorology, Vol. 58, Issue 5 https://doi.org/10.1007/s00484-013-0674-7	journal	June 2013
Pollen Allergens for Molecular Diagnosis Pablos, Isabel; Wildner, Sabrina; Asam, Claudia Current Allergy and Asthma Reports, Vol. 16, Issue 4 https://doi.org/10.1007/s11882-016-0603-z	journal	March 2016
Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions Mueller, Geoffrey A.; Min, Jungki; Foo, Alexander C. Y. Current Allergy and Asthma Reports, Vol. 19, Issue 3 https://doi.org/10.1007/s11882-019-0848-4	journal	February 2019
Human immunoglobulin variable region gene analysis by single cell RT-PCR Wang, Xiaowei; Stollar, B. David Journal of Immunological Methods, Vol. 244, Issue 1-2 https://doi.org/10.1016/S0022-1759(00)00260-X	journal	October 2000
Concentrations of the major birch tree allergen Bet v 1 in pollen and respirable fine particles in the atmosphere Schäppi, George F.; Suphioglu, Cenk; Taylor, Philip E. Journal of Allergy and Clinical Immunology, Vol. 100, Issue 5 https://doi.org/10.1016/S0091-6749(97)70170-2	journal	November 1997
Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: A quantitative IgE inhibition study with sera from different populations☆☆☆★★★ Niederberger, V.; Pauli, G.; Gronlundc, H. Journal of Allergy and Clinical Immunology, Vol. 102, Issue 4 https://doi.org/10.1016/S0091-6749(98)70273-8	journal	October 1998
The impact of different human IgG capture molecules on the kinetics analysis of antibody-antigen interaction Kamat, Vishal; Rafique, Ashique; Huang, Tammy Analytical Biochemistry, Vol. 593 https://doi.org/10.1016/j.ab.2020.113580	journal	March 2020
Enlarging the repertoire of therapeutic monoclonal antibodies platforms: domesticating half molecule exchange to produce stable IgG4 and IgG1 bispecific antibodies Yang, Xiaoyu; Ambrogelly, Alexandre Current Opinion in Biotechnology, Vol. 30 https://doi.org/10.1016/j.copbio.2014.09.001	journal	December 2014
The September epidemic of asthma exacerbations in children: A search for etiology Johnston, Neil W.; Johnston, Sebastian L.; Duncan, Joanne M. Journal of Allergy and Clinical Immunology, Vol. 115, Issue 1 https://doi.org/10.1016/j.jaci.2004.09.025	journal	January 2005
Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity Francis, James N.; James, Louisa K.; Paraskevopoulos, Giannis Journal of Allergy and Clinical Immunology, Vol. 121, Issue 5 https://doi.org/10.1016/j.jaci.2008.01.072	journal	May 2008
Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis Pauli, Gabrielle; Larsen, Tina H.; Rak, Sabina Journal of Allergy and Clinical Immunology, Vol. 122, Issue 5 https://doi.org/10.1016/j.jaci.2008.09.017	journal	November 2008
Clinical efficacy and immune regulation with peanut oral immunotherapy Jones, Stacie M.; Pons, Laurent; Roberts, Joseph L. Journal of Allergy and Clinical Immunology, Vol. 124, Issue 2 https://doi.org/10.1016/j.jaci.2009.05.022	journal	August 2009
Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Geroldinger-Simic, Marija; Zelniker, Thomas; Aberer, Werner Journal of Allergy and Clinical Immunology, Vol. 127, Issue 3 https://doi.org/10.1016/j.jaci.2010.10.027	journal	March 2011
Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies James, Louisa K.; Shamji, Mohamed H.; Walker, Samantha M. Journal of Allergy and Clinical Immunology, Vol. 127, Issue 2 https://doi.org/10.1016/j.jaci.2010.12.1080	journal	February 2011
Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens Akdis, Mübeccel; Akdis, Cezmi A. Journal of Allergy and Clinical Immunology, Vol. 133, Issue 3 https://doi.org/10.1016/j.jaci.2013.12.1088	journal	March 2014
The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses Shamji, Mohamed H.; Wilcock, Louisa K.; Wachholz, Petra A. Journal of Immunological Methods, Vol. 317, Issue 1-2 https://doi.org/10.1016/j.jim.2006.09.004	journal	December 2006
Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1 Kofler, Stefan; Asam, Claudia; Eckhard, Ulrich Journal of Molecular Biology, Vol. 422, Issue 1 https://doi.org/10.1016/j.jmb.2012.05.016	journal	September 2012
Proteomic analysis of the major birch allergen Bet v 1 predicts allergenicity for 15 birch species Schenk, Martijn F.; Cordewener, Jan H. G.; America, Antoine H. P. Journal of Proteomics, Vol. 74, Issue 8 https://doi.org/10.1016/j.jprot.2011.03.021	journal	August 2011
Pollen concentration and asthma exacerbations in Wake County, North Carolina, 2006–2012 Sun, Xuezheng; Waller, Anna; Yeatts, Karin B. Science of The Total Environment, Vol. 544 https://doi.org/10.1016/j.scitotenv.2015.11.100	journal	February 2016
Epitope Mapping by HDX-MS Elucidates the Surface Coverage of Antigens Associated with High Blocking Efficiency of Antibodies to Birch Pollen Allergen Zhang, Qian; Yang, Janice; Bautista, Joannie Analytical Chemistry, Vol. 90, Issue 19 https://doi.org/10.1021/acs.analchem.8b01864	journal	August 2018
Estimates of Present and Future Asthma Emergency Department Visits Associated With Exposure to Oak, Birch, and Grass Pollen in the United States Neumann, James E.; Anenberg, Susan C.; Weinberger, Kate R. GeoHealth, Vol. 3, Issue 1 https://doi.org/10.1029/2018GH000153	journal	January 2019
A chimeric human-cat fusion protein blocks cat-induced allergy Zhu, Daocheng; Kepley, Christopher L.; Zhang, Ke Nature Medicine, Vol. 11, Issue 4 https://doi.org/10.1038/nm1219	journal	March 2005
Integrated signalling pathways for mast-cell activation Gilfillan, Alasdair M.; Tkaczyk, Christine Nature Reviews Immunology, Vol. 6, Issue 3 https://doi.org/10.1038/nri1782	journal	February 2006
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy Gajhede, Michael; Osmark, Peter; Poulsen, Flemming M. Nature Structural Biology, Vol. 3, Issue 12 https://doi.org/10.1038/nsb1296-1040	journal	December 1996
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement Orengo, J. M.; Radin, A. R.; Kamat, V. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03636-8	journal	April 2018
Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children Busse, William W.; Morgan, Wayne J.; Gergen, Peter J. New England Journal of Medicine, Vol. 364, Issue 11 https://doi.org/10.1056/NEJMoa1009705	journal	March 2011
Effect of Avoidance on Peanut Allergy after Early Peanut Consumption Du Toit, George; Sayre, Peter H.; Roberts, Graham New England Journal of Medicine, Vol. 374, Issue 15 https://doi.org/10.1056/NEJMoa1514209	journal	April 2016
Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy Arvidsson, Monica B.; Löwhagen, Olle; Rak, Sabina Journal of Allergy and Clinical Immunology, Vol. 109, Issue 5 https://doi.org/10.1067/mai.2002.123868	journal	May 2002
Understanding the seasonal pattern of childhood asthma: Results from the national cooperative inner-city asthma study (NCICAS) Gergen, Peter J.; Mitchell, Herman; Lynn, Henry The Journal of Pediatrics, Vol. 141, Issue 5 https://doi.org/10.1067/mpd.2002.127510	journal	November 2002
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes Macdonald, L. E.; Karow, M.; Stevens, S. Proceedings of the National Academy of Sciences, Vol. 111, Issue 14 https://doi.org/10.1073/pnas.1323896111	journal	March 2014
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice Murphy, A. J.; Macdonald, L. E.; Stevens, S. Proceedings of the National Academy of Sciences, Vol. 111, Issue 14 https://doi.org/10.1073/pnas.1324022111	journal	March 2014
Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pascal, Kristen E.; Coleman, Christopher M.; Mujica, Alejandro O. Proceedings of the National Academy of Sciences, Vol. 112, Issue 28 https://doi.org/10.1073/pnas.1510830112	journal	June 2015
Isoforms of Bet v 1, the Major Birch Pollen Allergen, Analyzed by Liquid Chromatography, Mass Spectrometry, and cDNA Cloning Swoboda, Ines; Jilek, Alexander; Ferreira, Fátima Journal of Biological Chemistry, Vol. 270, Issue 6 https://doi.org/10.1074/jbc.270.6.2607	journal	February 1995
Mediators of inflammation in the early and the late phase of allergic rhinitis Hansen, Inga; Klimek, Ludger; Mösges, Ralph Current Opinion in Allergy and Clinical Immunology, Vol. 4, Issue 3 https://doi.org/10.1097/00130832-200406000-00004	journal	January 2004
Mechanisms of immunotherapy: IgG revisited Wachholz, Petra A.; Durham, Stephen R. Current Opinion in Allergy and Clinical Immunology, Vol. 4, Issue 4 https://doi.org/10.1097/01.all.0000136753.35948.c0	journal	January 2004
Seasonal Allergic Rhinitis: A focused systematic review and practice parameter update Wallace, Dana V.; Dykewicz, Mark S. Current Opinion in Allergy & Clinical Immunology, Vol. 17, Issue 4 https://doi.org/10.1097/ACI.0000000000000375	journal	January 2017
Oral Allergy Syndrome (Pollen-Food Allergy Syndrome) Price, Alexandra; Ramachandran, Sarika; Smith, Gideon P. Dermatitis, Vol. 26, Issue 2 https://doi.org/10.1097/DER.0000000000000087	journal	January 2015
Bet v 1‐specific IgE levels and PR‐10 reactivity discriminate silent sensitization from phenotypes of birch allergy Elisyutina, Olga; Fedenko, Elena; Campana, Raffaela Allergy, Vol. 74, Issue 12 https://doi.org/10.1111/all.13931	journal	June 2019
Human I g E against the major allergen B et v 1 – defining an epitope with limited cross‐reactivity between different PR ‐10 family proteins Levin, M.; Davies, A. M.; Liljekvist, M. Clinical & Experimental Allergy, Vol. 44, Issue 2 https://doi.org/10.1111/cea.12230	journal	January 2014
Side-effects of allergen-specific immunotherapy. A prospective multi-centre study Winther, L.; Arnved, J.; Malling, H. -J. Clinical Experimental Allergy, Vol. 36, Issue 3 https://doi.org/10.1111/j.1365-2222.2006.02340.x	journal	March 2006
IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa* Jarolim, E.; Rumpold, H.; Endler, A. T. Allergy, Vol. 44, Issue 6 https://doi.org/10.1111/j.1398-9995.1989.tb04169.x	journal	August 1989
When allergies complicate allergies Wickman, M. Allergy, Vol. 60 https://doi.org/10.1111/j.1398-9995.2005.00852.x	journal	May 2005
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*: ARIA: 2008 Update Bousquet, J.; Khaltaev, N.; Cruz, A. A. Allergy, Vol. 63 https://doi.org/10.1111/j.1398-9995.2007.01620.x	journal	March 2008
GA ² LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe Burbach, G. J.; Heinzerling, L. M.; Edenharter, G. Allergy, Vol. 64, Issue 10 https://doi.org/10.1111/j.1398-9995.2009.02089.x	journal	October 2009
Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy: Functional IgG4 correlates with clinical efficacy of allergen specific immunotherapy Shamji, M. H.; Ljørring, C.; Francis, J. N. Allergy, Vol. 67, Issue 2 https://doi.org/10.1111/j.1398-9995.2011.02745.x	journal	November 2011
High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes Croote, Derek; Darmanis, Spyros; Nadeau, Kari C. Science, Vol. 362, Issue 6420 https://doi.org/10.1126/science.aau2599	journal	December 2018
Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory Asrat, Seblewongel; Kaur, Navneet; Liu, Xia Science Immunology, Vol. 5, Issue 43 https://doi.org/10.1126/sciimmunol.aav8402	journal	January 2020
Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-Induced Allergic Rhinitis: A Randomized, Double-blind, Placebo Controlled Trial Shamji, Mohamed H.; Singh, Iesha; Layhadi, Janice A. American Journal of Respiratory and Critical Care Medicine https://doi.org/10.1164/rccm.202011-4107OC	journal	March 2021
Human IgE mAbs define variability in commercial Aspergillus extract allergen composition Wurth, Mark A.; Hadadianpour, Azadeh; Horvath, Dennis J. JCI Insight, Vol. 3, Issue 20 https://doi.org/10.1172/jci.insight.123387	journal	October 2018
Immunogold electron microscopy of soluble proteins: localization of Bet v I major allergen in ultra-thin sections of birch pollen after anhydrous fixation techniques. Grote, M. Journal of Histochemistry & Cytochemistry, Vol. 39, Issue 10 https://doi.org/10.1177/39.10.1940310	journal	October 1991
The associations between daily spring pollen counts, over-the-counter allergy medication sales, and asthma syndrome emergency department visits in New York City, 2002-2012 Ito, Kazuhiko; Weinberger, Kate R.; Robinson, Guy S. Environmental Health, Vol. 14, Issue 1 https://doi.org/10.1186/s12940-015-0057-0	journal	August 2015
Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis Guilbert, Ariane; Cox, Bianca; Bruffaerts, Nicolas Environmental Health, Vol. 17, Issue 1 https://doi.org/10.1186/s12940-018-0378-x	journal	April 2018
Allergen-specific immunotherapy Moote, William; Kim, Harold; Ellis, Anne K. Allergy, Asthma & Clinical Immunology, Vol. 14, Issue S2 https://doi.org/10.1186/s13223-018-0282-5	journal	September 2018
Development and application of ‘phosphoflow’ as a tool for immunomonitoring Wu, Sheng; Jin, Lei; Vence, Luis Expert Review of Vaccines, Vol. 9, Issue 6 https://doi.org/10.1586/erv.10.59	journal	June 2010
Structural Aspects of the Allergen-Antibody Interaction Pomés, Anna; Mueller, Geoffrey A.; Chruszcz, Maksymilian Frontiers in Immunology, Vol. 11 https://doi.org/10.3389/fimmu.2020.02067	journal	September 2020
Mapping of Conformational IgE Epitopes with Peptide-Specific Monoclonal Antibodies Reveals Simultaneous Binding of Different IgE Antibodies to a Surface Patch on the Major Birch Pollen Allergen, Bet v 1 Gieras, Anna; Cejka, Petra; Blatt, Katharina The Journal of Immunology, Vol. 186, Issue 9 https://doi.org/10.4049/jimmunol.1000804	journal	March 2011
Mapping Human Monoclonal IgE Epitopes on the Major Dust Mite Allergen Der p 2 Mueller, Geoffrey A.; Glesner, Jill; Daniel, Jacob L. The Journal of Immunology, Vol. 205, Issue 8 https://doi.org/10.4049/jimmunol.2000295	journal	September 2020
The Association of Tree Pollen Concentration Peaks and Allergy Medication Sales in New York City: 2003–2008 Sheffield, Perry E.; Weinberger, Kate R.; Ito, Kazuhiko ISRN Allergy, Vol. 2011 https://doi.org/10.5402/2011/537194	journal	April 2011
Pharmacologic Treatment of Seasonal Allergic Rhinitis: Synopsis of Guidance From the 2017 Joint Task Force on Practice Parameters Wallace, Dana V.; Dykewicz, Mark S.; Oppenheimer, John Annals of Internal Medicine, Vol. 167, Issue 12 https://doi.org/10.7326/M17-2203	journal	November 2017

Similar Records

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

Journal Article · 2017 · Cell Host & Microbe · OSTI ID:1477123

Yu, Fei; Song, He; Wu, Yanling; +22 more

Structure and epitope of a neutralizing monoclonal antibody that targets the stem helix of β coronaviruses

Journal Article · 2023 · Federation of European Biochemical Societies (FEBS) Journal · OSTI ID:2423654

Deshpande, Ashlesha; Schormann, Nobert; Piepenbrink, Mike S.; +3 more

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Journal Article · 2018 · Nature Communications · OSTI ID:1498306

Bangaru, Sandhya; Zhang, Heng; Gilchuk, Iuliia M.; +15 more

Title: Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response

Citation Formats

References (61)

Similar Records

Related Subjects