Design, Synthesis, and Utility of Defined Molecular Scaffolds

Sato, Daisuke; Wu, Zhiyuan; Fujita, Hikaru; Lindsey, Jonathan

doi:10.3390/org2030013

Title: Design, Synthesis, and Utility of Defined Molecular Scaffolds

Journal Article · 10 July 2021 · Organics

DOI: https://doi.org/10.3390/org2030013 · OSTI ID:1807607

; Wu, Zhiyuan;

;

A growing theme in chemistry is the joining of multiple organic molecular building blocks to create functional molecules. Diverse derivatizable structures—here termed “scaffolds” comprised of “hubs”—provide the foundation for systematic covalent organization of a rich variety of building blocks. This review encompasses 30 tri- or tetra-armed molecular hubs (e.g., triazine, lysine, arenes, dyes) that are used directly or in combination to give linear, cyclic, or branched scaffolds. Each scaffold is categorized by graph theory into one of 31 trees to express the molecular connectivity and overall architecture. Rational chemistry with exacting numbers of derivatizable sites is emphasized. The incorporation of water-solubilization motifs, robust or self-immolative linkers, enzymatically cleavable groups and functional appendages affords immense (and often late-stage) diversification of the scaffolds. Altogether, 107 target molecules are reviewed along with 19 syntheses to illustrate the distinctive chemistries for creating and derivatizing scaffolds. The review covers the history of the field up through 2020, briefly touching on statistically derivatized carriers employed in immunology as counterpoints to the rationally assembled and derivatized scaffolds here, although most citations are from the past two decades. The scaffolds are used widely in fields ranging from pure chemistry to artificial photosynthesis and biomedical sciences.

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE

Grant/Contract Number:: FG02-05ER15661

OSTI ID:: 1807607

Journal Information:: Organics, Journal Name: Organics Journal Issue: 3 Vol. 2; ISSN 2673-401X

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

References (332)

Structural and conformational study of substituted triazines by15N NMR and x-ray analysis Amm, Michel; Platzer, Nicole; Guilhem, Jean Magnetic Resonance in Chemistry, Vol. 36, Issue 8 https://doi.org/10.1002/(SICI)1097-458X(199808)36:8<587::AID-OMR347>3.0.CO;2-B	journal	August 1998
NMR studies of exchange between triazine rotamers Birkett, Helen E.; Harris, Robin K.; Hodgkinson, Paul Magnetic Resonance in Chemistry, Vol. 38, Issue 7 https://doi.org/10.1002/1097-458X(200007)38:7<504::AID-MRC710>3.0.CO;2-7	journal	January 2000
Tetrafunctional Photoaffinity Labels Based on Nakanishi'sm-Nitroalkoxy-Substituted Phenyltrifluoromethyldiazirine Daghish, Mohammed; Hennig, Lothar; Findeisen, Matthias Angewandte Chemie International Edition, Vol. 41, Issue 13 https://doi.org/10.1002/1521-3773(20020703)41:13<2293::AID-ANIE2293>3.0.CO;2-9	journal	July 2002
Mixed Isotope Photoaffinity Reagents for Identification of Small-Molecule Targets by Mass Spectrometry Lamos, Shane M.; Krusemark, Casey J.; McGee, Christopher J. Angewandte Chemie International Edition, Vol. 45, Issue 26 https://doi.org/10.1002/anie.200600743	journal	June 2006
Molecular Scaffolds Using Multiple Orthogonal Conjugations: Applications in Chemical Biology and Drug Discovery Beal, David M.; Jones, Lyn H. Angewandte Chemie International Edition, Vol. 51, Issue 26 https://doi.org/10.1002/anie.201200002	journal	April 2012
The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy Legigan, Thibaut; Clarhaut, Jonathan; Tranoy-Opalinski, Isabelle Angewandte Chemie International Edition, Vol. 51, Issue 46 https://doi.org/10.1002/anie.201204935	journal	September 2012
Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications Alouane, Ahmed; Labruère, Raphaël; Le Saux, Thomas Angewandte Chemie International Edition, Vol. 54, Issue 26 https://doi.org/10.1002/anie.201500088	journal	June 2015
Boron‐Containing Probes for Non‐optical High‐Resolution Imaging of Biological Samples Kabatas, Selda; Agüi‐Gonzalez, Paola; Saal, Kim‐Ann Angewandte Chemie International Edition, Vol. 58, Issue 11 https://doi.org/10.1002/anie.201812032	journal	March 2019
Zur Kenntniss der Cyanurverbindungen Diels, Otto Berichte der deutschen chemischen Gesellschaft, Vol. 32, Issue 1 https://doi.org/10.1002/cber.189903201103	journal	January 1899
Synthesis and Evaluation of New Thiodigalactoside-Based Chemical Probes to Label Galectin-3 van Scherpenzeel, Monique; Moret, Ed E.; Ballell, Lluis ChemBioChem, Vol. 10, Issue 10 https://doi.org/10.1002/cbic.200900198	journal	July 2009
Study on 1,3,5-Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species Kunishima, Munetaka; Ujigawa, Takae; Nagaoka, Yoshie Chemistry - A European Journal, Vol. 18, Issue 49 https://doi.org/10.1002/chem.201202236	journal	October 2012
A New Approach for the Photosynthetic Antenna-Reaction Center Complex with a Model Organized Around an s -Triazine Linker Kuhri, Susanne; Charalambidis, Georgios; Angaridis, Panagiotis A. Chemistry - A European Journal, Vol. 20, Issue 7 https://doi.org/10.1002/chem.201302632	journal	January 2014
Selective Alkylation of C-Rich Bulge Motifs in Nucleic Acids by Quinone Methide Derivatives Lönnberg, Tuomas; Hutchinson, Mark; Rokita, Steven Chemistry - A European Journal, Vol. 21, Issue 37 https://doi.org/10.1002/chem.201502014	journal	July 2015
Azlactone Reaction Developments de Castro, Pedro P.; Carpanez, Arthur G.; Amarante, Giovanni W. Chemistry - A European Journal, Vol. 22, Issue 30 https://doi.org/10.1002/chem.201600071	journal	June 2016
ChemInform Abstract: Isoserine-Based Biotinylated Photoaffinity Probes that Interact with Penicillin-Binding Protein 1b. Ruehl, Thomas; Volke, Daniela; Stembera, Katherina ChemInform, Vol. 33, Issue 46 https://doi.org/10.1002/chin.200246053	journal	November 2002
A Diels-Alder/Retro-Diels-Alder Approach for the Enantioselective Synthesis of Microbial Butenolides Citron, Christian A.; Wickel, Susanne M.; Schulz, Barbara European Journal of Organic Chemistry https://doi.org/10.1002/ejoc.201200991	journal	October 2012
Disulfide Formation Strategies in Peptide Synthesis: Disulfide Formation Strategies in Peptide Synthesis Postma, Tobias M.; Albericio, Fernando European Journal of Organic Chemistry, Vol. 2014, Issue 17 https://doi.org/10.1002/ejoc.201402149	journal	April 2014
Formal C-H-Azidation - Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes: Formal C-H-Azidation Based Shortcut to Diazido Building Blocks Yoshida, Suguru; Misawa, Yoshihiro; Hosoya, Takamitsu European Journal of Organic Chemistry, Vol. 2014, Issue 19 https://doi.org/10.1002/ejoc.201402516	journal	May 2014
5-Alkoxyoxazole - A Versatile Building Block in (Bio)organic Synthesis: 5-Alkoxyoxazole - A Versatile Building Block in (Bio)organic Synthesis Jouanno, Laurie-Anne; Renault, Kévin; Sabot, Cyrille European Journal of Organic Chemistry, Vol. 2016, Issue 20 https://doi.org/10.1002/ejoc.201600127	journal	April 2016
Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides: Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides Pícha, Jan; Fabre, Benjamin; Buděšínský, Miloš European Journal of Organic Chemistry, Vol. 2018, Issue 37 https://doi.org/10.1002/ejoc.201800601	journal	July 2018
Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions: Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions Pantin, Mathilde; Caillé, Julien; Boeda, Fabien European Journal of Organic Chemistry, Vol. 2019, Issue 44 https://doi.org/10.1002/ejoc.201901350	journal	November 2019
A ⁶⁴ Cu-porphyrin-based dual-modal molecular probe with integrin α _v β ₃ targeting function for tumour imaging Fan, Di; Wang, Kai; Gao, Hannan Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 63, Issue 5 https://doi.org/10.1002/jlcr.3833	journal	March 2020
A survey of acid catalysts in dipyrromethanecarbinol condensations leading to meso -substituted porphyrins Geier, G. Richard; Callinan, Jennifer B.; Dharma Rao, Polisetti Journal of Porphyrins and Phthalocyanines, Vol. 05, Issue 12 https://doi.org/10.1002/jpp.387	journal	December 2001
Structural investigations of three triazines: solution-state NMR studies of internal rotation and structural information from solid-state NMR, plus a full structure determination from powder x-ray diffraction in one case Birkett, Helen E.; Cherryman, Julian C.; Chippendale, A. Margaret Magnetic Resonance in Chemistry, Vol. 41, Issue 5 https://doi.org/10.1002/mrc.1185	journal	January 2003
Synthesis and Characterization of Novel Fluoro-glycosylated Porphyrins that can be Utilized as Theranostic Agents Arja, Katriann; Elgland, Mathias; Appelqvist, Hanna ChemistryOpen, Vol. 7, Issue 7 https://doi.org/10.1002/open.201800020	journal	May 2018
The application of an aryl hydrazine linker prevents ß-elimination side products in the SPPS of C -terminal cysteine peptides: EFFICIENT SYNTHESIS OF C -TERMINAL CYSTEINE PEPTIDES Ni, Shuaijian; Zhang, Huibin; Huang, Wenlong Journal of Peptide Science, Vol. 16, Issue 6 https://doi.org/10.1002/psc.1240	journal	May 2010
Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold: SYNTHESIS OF A PROTEIN MIMIC BY SEQUENTIAL CuAAC OF CYCLIC PEPTIDES Werkhoven, Paul R.; van de Langemheen, Helmus; van der Wal, Steffen Journal of Peptide Science, Vol. 20, Issue 4 https://doi.org/10.1002/psc.2624	journal	March 2014
Advances in Fmoc solid‐phase peptide synthesis Behrendt, Raymond; White, Peter; Offer, John Journal of Peptide Science, Vol. 22, Issue 1 https://doi.org/10.1002/psc.2836	journal	January 2016
Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides: Syntheses of azido amino acids Pícha, Jan; Buděšínský, Miloš; Macháčková, Kateřina Journal of Peptide Science, Vol. 23, Issue 3 https://doi.org/10.1002/psc.2968	journal	January 2017
Inverse electron demand Diels-Alder (IEDDA) reactions in peptide chemistry Pagel, Mareen Journal of Peptide Science, Vol. 25, Issue 1 https://doi.org/10.1002/psc.3141	journal	December 2018
Synthesis and conformational studies of pseudopeptides containing an unsymmetrical triazine scaffold Bourguet, Erika; Correia, Isabelle; Dorgeret, Bertrand Journal of Peptide Science, Vol. 14, Issue 5 https://doi.org/10.1002/psc.944	journal	May 2008
Sugar γ-Amino Acids as Building Blocks for the Synthesis of Cyclic Neoglycopeptides. Richard, Mylène; Ariztia, Julen; Lamandé-Langle, Sandrine ChemistrySelect, Vol. 3, Issue 31 https://doi.org/10.1002/slct.201802146	journal	August 2018
Metal–Organic Frameworks for Biomedical Applications Yang, Jie; Yang, Ying‐Wei Small, Vol. 16, Issue 10 https://doi.org/10.1002/smll.201906846	journal	March 2020
3-(1-Piperidinyl)alanine formation during the preparation ofC-terminal cysteine peptides with the Fmoc/t-Bu strategy Lukszo, Jan; Patterson, Dale; Albericio, Fernando Letters in Peptide Science, Vol. 3, Issue 3 https://doi.org/10.1007/BF00132978	journal	July 1996
β-galactoside prodrugs of doxorubicin for application in antibody directed enzyme prodrug therapy/prodrug monotherapy Devalapally, HariKrishna; Navath, Raghavendra Swamy; Yenamandra, Venkateshwarlu Archives of Pharmacal Research, Vol. 30, Issue 6 https://doi.org/10.1007/BF02977634	journal	June 2007
A review on molecular topology: applying graph theory to drug discovery and design Amigó, José María; Gálvez, Jorge; Villar, Vincent M. Naturwissenschaften, Vol. 96, Issue 7 https://doi.org/10.1007/s00114-009-0536-7	journal	June 2009
A review on the clinical uses of SPECT/CT Mariani, Giuliano; Bruselli, Laura; Kuwert, Torsten European Journal of Nuclear Medicine and Molecular Imaging, Vol. 37, Issue 10 https://doi.org/10.1007/s00259-010-1390-8	journal	February 2010
Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence Israel, Ora; Pellet, O.; Biassoni, L. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, Issue 10 https://doi.org/10.1007/s00259-019-04404-6	journal	July 2019
Side reactions in the SPPS of Cys-containing peptides Stathopoulos, Panagiotis; Papas, Serafim; Pappas, Charalambos Amino Acids, Vol. 44, Issue 5 https://doi.org/10.1007/s00726-013-1471-7	journal	March 2013
An amino acid-based heterofunctional cross-linking reagent Lelle, Marco; Peneva, Kalina Amino Acids, Vol. 46, Issue 5 https://doi.org/10.1007/s00726-014-1685-3	journal	February 2014
Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation Jaradat, Da’san M. M. Amino Acids, Vol. 50, Issue 1 https://doi.org/10.1007/s00726-017-2516-0	journal	November 2017
Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities Liu, S. P.; Zhou, L.; Lakshminarayanan, R. International Journal of Peptide Research and Therapeutics, Vol. 16, Issue 3 https://doi.org/10.1007/s10989-010-9230-z	journal	August 2010
Paradigms in Fluorescence Molecular Imaging: Maximizing Measurement of Biological Changes in Disease, Therapeutic Efficacy, and Toxicology/Safety Peterson, Jeffrey D. Molecular Imaging and Biology, Vol. 21, Issue 4 https://doi.org/10.1007/s11307-018-1273-0	journal	September 2018
Molecular imaging of enzyme activity in vivo using activatable probes Yan, Runqi; Ye, Deju Science Bulletin, Vol. 61, Issue 21 https://doi.org/10.1007/s11434-016-1175-y	journal	November 2016
Antibody-drug conjugates: recent advances in conjugation and linker chemistries Tsuchikama, Kyoji; An, Zhiqiang Protein & Cell, Vol. 9, Issue 1 https://doi.org/10.1007/s13238-016-0323-0	journal	October 2016
Immunochemical studies of dextran coupled ragweed pollen allergen, antigen E Piao King, Te; Kochoumian, Lucia; Ishizaka, Kimishige Archives of Biochemistry and Biophysics, Vol. 169, Issue 2 https://doi.org/10.1016/0003-9861(75)90189-7	journal	August 1975
Synthesis of biotinylated bis(d-glucose) derivatives for glucose transporter photoaffinity labelling Hashimoto, Makoto; Hatanaka, Yasumaru; Yang, Jing Carbohydrate Research, Vol. 331, Issue 2 https://doi.org/10.1016/S0008-6215(01)00025-8	journal	March 2001
Molecular modelling studies of side-chain rotation in substituted triazine rings Birkett, Helen E.; Cherryman, Julian C.; Margaret Chippendale, A. Journal of Molecular Structure, Vol. 602-603 https://doi.org/10.1016/S0022-2860(01)00726-8	journal	January 2002
Farnesyl and geranylgeranyl pyrophosphate analogs incorporating benzoylbenzyl ethers: Synthesis and inhibition of yeast protein farnesyltransferase Gaon, Igor; Turek, Tammy C.; Distefano, Mark D. Tetrahedron Letters, Vol. 37, Issue 49 https://doi.org/10.1016/S0040-4039(96)02066-7	journal	December 1996
Synthesis and characterization of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride Kunishima, Munetaka; Kawachi, Chiho; Iwasaki, Fumiaki Tetrahedron Letters, Vol. 40, Issue 29 https://doi.org/10.1016/S0040-4039(99)00968-5	journal	July 1999
Keyhole limpet hemocyanin (KLH): a biomedical review Harris, J. R.; Markl∗, J. Micron, Vol. 30, Issue 6 https://doi.org/10.1016/S0968-4328(99)00036-0	journal	December 1999
Kappa-squared: from nuisance to new sense van der Meer, B. W. Reviews in Molecular Biotechnology, Vol. 82, Issue 3 https://doi.org/10.1016/S1389-0352(01)00037-X	journal	January 2002
The engineering of membrane-permeable peptides Carrigan, Christina N.; Imperiali, Barbara Analytical Biochemistry, Vol. 341, Issue 2 https://doi.org/10.1016/j.ab.2005.03.026	journal	June 2005
PEGylation in anti-cancer therapy: An overview Mishra, Prajna; Nayak, Bismita; Dey, R. K. Asian Journal of Pharmaceutical Sciences, Vol. 11, Issue 3 https://doi.org/10.1016/j.ajps.2015.08.011	journal	June 2016
Recent developments in multimodality fluorescence imaging probes Zhao, Jianhong; Chen, Junwei; Ma, Shengnan Acta Pharmaceutica Sinica B, Vol. 8, Issue 3 https://doi.org/10.1016/j.apsb.2018.03.010	journal	May 2018
Multifunctionalization of cyanuric chloride for the stepwise synthesis of potential multimodal imaging chemical entities Calvete, Mário J. F.; Pinto, Sara M. A.; Burrows, Hugh D. Arabian Journal of Chemistry, Vol. 13, Issue 1 https://doi.org/10.1016/j.arabjc.2018.06.005	journal	January 2020
A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist Brahimi, Fouad; Liu, Jing; Malakhov, Andrey Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1800, Issue 9 https://doi.org/10.1016/j.bbagen.2010.06.007	journal	September 2010
A ratiometric theranostic probe for tumor targeting therapy and self-therapeutic monitoring Li, Shi-Ying; Cheng, Hong; Xie, Bo-Ru Biomaterials, Vol. 104 https://doi.org/10.1016/j.biomaterials.2016.07.024	journal	October 2016
Reconsidering azobenzene as a component of small-molecule hypoxia-mediated cancer drugs: A theranostic case study Verwilst, Peter; Han, Jiyou; Lee, Jiyeong Biomaterials, Vol. 115 https://doi.org/10.1016/j.biomaterials.2016.11.023	journal	January 2017
Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies Wang, Tao; Vineberg, Jacob G.; Honda, Tadashi Bioorganic Chemistry, Vol. 76 https://doi.org/10.1016/j.bioorg.2017.12.018	journal	February 2018
A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ Lee, Yeongju; Chung, Brian; Ko, Daseul Bioorganic Chemistry, Vol. 91 https://doi.org/10.1016/j.bioorg.2019.103141	journal	October 2019
Exploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups Sharma, Anamika; Kumar, Ashish; El-Faham, Ayman Bioorganic Chemistry, Vol. 104 https://doi.org/10.1016/j.bioorg.2020.104334	journal	November 2020
A generic building block for C- and N-terminal protein-labeling and protein-immobilization Watzke, A.; Gutierrezrodriguez, M.; Kohn, M. Bioorganic & Medicinal Chemistry, Vol. 14, Issue 18 https://doi.org/10.1016/j.bmc.2006.05.006	journal	September 2006
Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis Dijkgraaf, Ingrid; Van de Vijver, Pieter; Dirksen, Anouk Bioorganic & Medicinal Chemistry, Vol. 21, Issue 12 https://doi.org/10.1016/j.bmc.2013.04.002	journal	June 2013
Sequential and parallel dual labeling of nanoparticles using click chemistry Zong, Hong; Goonewardena, Sascha N.; Chang, Huai-Ning Bioorganic & Medicinal Chemistry, Vol. 22, Issue 21 https://doi.org/10.1016/j.bmc.2014.07.015	journal	November 2014
A photo-cleavable biotin affinity tag for the facile release of a photo-crosslinked carbohydrate-binding protein Chang, Tsung-Che; Adak, Avijit K.; Lin, Ting-Wei Bioorganic & Medicinal Chemistry, Vol. 24, Issue 6 https://doi.org/10.1016/j.bmc.2016.01.050	journal	March 2016
An efficient chemical approach to bispecific antibodies and antibodies of high valency Gavrilyuk, Julia I.; Wuellner, Ulrich; Salahuddin, Syed Bioorganic & Medicinal Chemistry Letters, Vol. 19, Issue 14 https://doi.org/10.1016/j.bmcl.2009.05.047	journal	July 2009
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid Zhang, Liying; Zhang, Yingxia; Dong, Jizhe Bioorganic & Medicinal Chemistry Letters, Vol. 22, Issue 2 https://doi.org/10.1016/j.bmcl.2011.11.123	journal	January 2012
Synthetic pathways to water-soluble phthalocyanines and close analogs Dumoulin, Fabienne; Durmuş, Mahmut; Ahsen, Vefa Coordination Chemistry Reviews, Vol. 254, Issue 23-24 https://doi.org/10.1016/j.ccr.2010.05.002	journal	December 2010
Self-immolative chemistry in nanomedicine Gisbert-Garzarán, M.; Manzano, M.; Vallet-Regí, M. Chemical Engineering Journal, Vol. 340 https://doi.org/10.1016/j.cej.2017.12.098	journal	May 2018
Inflammatory Caspases Martinon, Fabio; Tschopp, Jürg Cell, Vol. 117, Issue 5 https://doi.org/10.1016/j.cell.2004.05.004	journal	May 2004
Protein Chemical Modification on Endogenous Amino Acids Baslé, Emmanuel; Joubert, Nicolas; Pucheault, Mathieu Chemistry & Biology, Vol. 17, Issue 3 https://doi.org/10.1016/j.chembiol.2010.02.008	journal	March 2010
AIE Luminogens for Bioimaging and Theranostics: From Organelles to Animals Qian, Jun; Tang, Ben Zhong Chem, Vol. 3, Issue 1 https://doi.org/10.1016/j.chempr.2017.05.010	journal	July 2017
“Doubly Orthogonal” Labeling of Peptides and Proteins Tessier, Romain; Ceballos, Javier; Guidotti, Nora Chem, Vol. 5, Issue 8 https://doi.org/10.1016/j.chempr.2019.06.022	journal	August 2019
Mitochondria-targeting Pt/Mn porphyrins as efficient photosensitizers for magnetic resonance imaging and photodynamic therapy Yang, Mengqian; Deng, Jingran; Guo, Ding Dyes and Pigments, Vol. 166 https://doi.org/10.1016/j.dyepig.2019.03.048	journal	July 2019
Caspases in Cell Death, Inflammation, and Disease Van Opdenbosch, Nina; Lamkanfi, Mohamed Immunity, Vol. 50, Issue 6 https://doi.org/10.1016/j.immuni.2019.05.020	journal	June 2019
PEG — A versatile conjugating ligand for drugs and drug delivery systems Kolate, Atul; Baradia, Dipesh; Patil, Sushilkumar Journal of Controlled Release, Vol. 192 https://doi.org/10.1016/j.jconrel.2014.06.046	journal	October 2014
Development of acid-catalyzed fluorous benzylating reagents based on a triazinedione core Kunishima, Munetaka; Asao, Ryohei; Yamada, Kohei Journal of Fluorine Chemistry, Vol. 190 https://doi.org/10.1016/j.jfluchem.2016.09.003	journal	October 2016
Recent development in peptide coupling reagents Al-Warhi, Tarfah I.; Al-Hazimi, Hassan M. A.; El-Faham, Ayman Journal of Saudi Chemical Society, Vol. 16, Issue 2 https://doi.org/10.1016/j.jscs.2010.12.006	journal	April 2012
Site-Selective Protein Modification: From Functionalized Proteins to Functional Biomaterials Shadish, Jared A.; DeForest, Cole A. Matter, Vol. 2, Issue 1 https://doi.org/10.1016/j.matt.2019.11.011	journal	January 2020
Review: PET imaging with macro- and middle-sized molecular probes Mukai, Hidefumi; Watanabe, Yasuyoshi Nuclear Medicine and Biology, Vol. 92 https://doi.org/10.1016/j.nucmedbio.2020.06.007	journal	January 2021
Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers Thompson, M. S.; Vadala, T. P.; Vadala, M. L. Polymer, Vol. 49, Issue 2 https://doi.org/10.1016/j.polymer.2007.10.029	journal	January 2008
Spectrofluorimetric determination of trace nitrite with a novel fluorescent probe Liu, Qing-Hao; Yan, Xi-Long; Guo, Jin-Chun Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 73, Issue 5 https://doi.org/10.1016/j.saa.2009.03.018	journal	September 2009
Synthesis, structural, spectroscopic, computational and cytotoxic studies of BODIPY dyes Laine, M.; Barbosa, N. A.; Kochel, A. Sensors and Actuators B: Chemical, Vol. 238 https://doi.org/10.1016/j.snb.2016.07.103	journal	January 2017
Enzyme activity – it's all about image Baruch, Amos; Jeffery, Douglas A.; Bogyo, Matthew Trends in Cell Biology, Vol. 14, Issue 1 https://doi.org/10.1016/j.tcb.2003.11.002	journal	January 2004
Amide bond formation and peptide coupling Montalbetti, Christian A. G. N.; Falque, Virginie Tetrahedron, Vol. 61, Issue 46 https://doi.org/10.1016/j.tet.2005.08.031	journal	November 2005
Recent applications of 2,4,6-trichloro-1,3,5-triazine and its derivatives in organic synthesis Blotny, Grzegorz Tetrahedron, Vol. 62, Issue 41, p. 9507-9522 https://doi.org/10.1016/j.tet.2006.07.039	journal	October 2006
The umpolung of substituent effect in nucleophilic aromatic substitution. A new approach to the synthesis of N,N-disubstituted melamines (triazine triskelions) under mild reaction conditions Kolesinska, Beata; Kaminski, Zbigniew J. Tetrahedron, Vol. 65, Issue 18 https://doi.org/10.1016/j.tet.2009.03.017	journal	May 2009
Synthesis of novel amphiphilic conjugates with a biological recognition function for developing targeted triggered liposomal delivery systems Brodersen, Nicolai; Arbuzova, Anna; Herrmann, Andreas Tetrahedron, Vol. 67, Issue 40 https://doi.org/10.1016/j.tet.2011.07.089	journal	October 2011
Strategies toward the synthesis of amphiphilic porphyrins Pisarek, Sabina; Maximova, Ksenia; Gryko, Dorota Tetrahedron, Vol. 70, Issue 38 https://doi.org/10.1016/j.tet.2014.05.090	journal	September 2014
Identification of diamine linkers with differing reactivity and their application in the synthesis of melamine dendrimers Moreno, Karlos X.; Simanek, Eric E. Tetrahedron Letters, Vol. 49, Issue 7 https://doi.org/10.1016/j.tetlet.2007.12.056	journal	February 2008
An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker Tiberghien, Arnaud C.; Gregson, Stephen J.; Masterson, Luke A. Tetrahedron Letters, Vol. 58, Issue 46 https://doi.org/10.1016/j.tetlet.2017.10.010	journal	November 2017
Synthesis of tris-tertiary amine CycloTriVeratrilene (TACTV) derivatives as water soluble pre-organized three aromatic ring containing molecular scaffolds for the construction of protein mimics Longin, Ondřej; van de Langemheen, Helmus; Gannon, Susan Tetrahedron Letters, Vol. 60, Issue 47 https://doi.org/10.1016/j.tetlet.2019.151245	journal	November 2019
Recent Fascinating Aspects of the CuAAC Click Reaction Meldal, Morten; Diness, Frederik Trends in Chemistry, Vol. 2, Issue 6 https://doi.org/10.1016/j.trechm.2020.03.007	journal	June 2020
Perspectives About Self-Immolative Drug Delivery Systems Gonzaga, Rodrigo Vieira; do Nascimento, Lucas Adriano; Santos, Soraya Silva Journal of Pharmaceutical Sciences, Vol. 109, Issue 11 https://doi.org/10.1016/j.xphs.2020.08.014	journal	November 2020
Immune responses to hapten conjugates in vitro Kontiainen, Sirkka; Mäkelä, O.; Hurme, M. Quarterly Reviews of Biophysics, Vol. 8, Issue 4 https://doi.org/10.1017/S0033583500001979	journal	November 1975
Multifunctional Fluorescent Probe for Sequential Detections of Glutathione and Caspase-3 in Vitro and in Cells Huang, Rui; Wang, Xijun; Wang, Dingli Analytical Chemistry, Vol. 85, Issue 13 https://doi.org/10.1021/ac4014012	journal	June 2013
Bispyrene–Fluorescein Hybrid Based FRET Cassette: A Convenient Platform toward Ratiometric Time-Resolved Probe for Bioanalytical Applications Wu, Yong-Xiang; Zhang, Xiao-Bing; Li, Jun-Bin Analytical Chemistry, Vol. 86, Issue 20 https://doi.org/10.1021/ac502863m	journal	October 2014
Chemical Protein Synthesis with the α-Ketoacid–Hydroxylamine Ligation Bode, Jeffrey W. Accounts of Chemical Research, Vol. 50, Issue 9 https://doi.org/10.1021/acs.accounts.7b00277	journal	August 2017
Activity-Based Optical Sensing Enabled by Self-Immolative Scaffolds: Monitoring of Release Events by Fluorescence or Chemiluminescence Output Gnaim, Samer; Shabat, Doron Accounts of Chemical Research, Vol. 52, Issue 10 https://doi.org/10.1021/acs.accounts.9b00338	journal	September 2019
Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin Hai, Zijuan; Wu, Jingjing; Saimi, Dilizhatai Analytical Chemistry, Vol. 90, Issue 3 https://doi.org/10.1021/acs.analchem.7b05251	journal	January 2018
Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes Gai, Yongkang; Xiang, Guangya; Ma, Xiang Bioconjugate Chemistry, Vol. 27, Issue 3 https://doi.org/10.1021/acs.bioconjchem.6b00034	journal	February 2016
Novel Strategy for Preparing Dual-Modality Optical/PET Imaging Probes via Photo-Click Chemistry Sun, Lingyi; Ding, Jiule; Xing, Wei Bioconjugate Chemistry, Vol. 27, Issue 5 https://doi.org/10.1021/acs.bioconjchem.6b00115	journal	April 2016
Versatile Platform for the Synthesis of Orthogonally Cleavable Heteromultifunctional Cross-Linkers Sorkin, Michelle R.; Walker, Joshua A.; Brown, Joseph S. Bioconjugate Chemistry, Vol. 28, Issue 4 https://doi.org/10.1021/acs.bioconjchem.7b00033	journal	February 2017
Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies Renault, Kévin; Fredy, Jean Wilfried; Renard, Pierre-Yves Bioconjugate Chemistry, Vol. 29, Issue 8 https://doi.org/10.1021/acs.bioconjchem.8b00252	journal	June 2018
Activatable Near-Infrared Fluorescence Imaging Using PEGylated Bacteriochlorin-Based Chlorin and BODIPY-Dyads as Probes for Detecting Cancer Ogata, Fusa; Nagaya, Tadanobu; Maruoka, Yasuhiro Bioconjugate Chemistry, Vol. 30, Issue 1 https://doi.org/10.1021/acs.bioconjchem.8b00820	journal	November 2018
Improved in Vivo Targeting Capability and Pharmacokinetics of ^99m Tc-Labeled isoDGR by Dimerization and Albumin-Binding for Glioma Imaging Gao, Hannan; Luo, Chuangwei; Yang, Guangjie Bioconjugate Chemistry, Vol. 30, Issue 7 https://doi.org/10.1021/acs.bioconjchem.9b00323	journal	May 2019
Unprecedented Affinity Labeling of Carbohydrate-Binding Proteins with s -Triazinyl Glycosides Masselin, Arnaud; Petrelli, Antoine; Donzel, Maxime Bioconjugate Chemistry, Vol. 30, Issue 9 https://doi.org/10.1021/acs.bioconjchem.9b00432	journal	August 2019
A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids Fantoni, Nicolò Zuin; El-Sagheer, Afaf H.; Brown, Tom Chemical Reviews, Vol. 121, Issue 12 https://doi.org/10.1021/acs.chemrev.0c00928	journal	January 2021
Dendritic, Oligomeric, and Polymeric Self-Immolative Molecular Amplification Roth, Michal E.; Green, Ori; Gnaim, Samer Chemical Reviews, Vol. 116, Issue 3 https://doi.org/10.1021/acs.chemrev.5b00372	journal	September 2015
Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation Herzberger, Jana; Niederer, Kerstin; Pohlit, Hannah Chemical Reviews, Vol. 116, Issue 4 https://doi.org/10.1021/acs.chemrev.5b00441	journal	December 2015
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations Agouridas, Vangelis; El Mahdi, Ouafâa; Diemer, Vincent Chemical Reviews, Vol. 119, Issue 12 https://doi.org/10.1021/acs.chemrev.8b00712	journal	May 2019
Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations Singh, Harwinder; Tiwari, Karishma; Tiwari, Rajeshwari Chemical Reviews, Vol. 119, Issue 22 https://doi.org/10.1021/acs.chemrev.9b00379	journal	November 2019
Heuristics from Modeling of Spectral Overlap in Förster Resonance Energy Transfer (FRET) Qi, Qi; Taniguchi, Masahiko; Lindsey, Jonathan S. Journal of Chemical Information and Modeling, Vol. 59, Issue 2 https://doi.org/10.1021/acs.jcim.8b00753	journal	November 2018
Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer Renard, Emma; Dancer, Pierre-Alix; Portal, Christophe Journal of Medicinal Chemistry, Vol. 63, Issue 5 https://doi.org/10.1021/acs.jmedchem.9b01407	journal	December 2019
Study of the Reactivities of Acid-Catalyzed O-Benzylating Reagents Based on Structural Isomers of 1,3,5-Triazine Fujita, Hikaru; Hayakawa, Naoko; Kunishima, Munetaka The Journal of Organic Chemistry, Vol. 80, Issue 21 https://doi.org/10.1021/acs.joc.5b02059	journal	October 2015
Selective and Sequential Aminolysis of Benzotrifuranone: Synergism of Electronic Effects and Ring Strain Gradient Baker, Matthew B.; Ferreira, Renan B.; Tasseroul, Jonathan The Journal of Organic Chemistry, Vol. 81, Issue 19 https://doi.org/10.1021/acs.joc.6b01867	journal	September 2016
Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species Fujita, Hikaru; Kakuyama, Satoshi; Fukuyoshi, Shuichi The Journal of Organic Chemistry, Vol. 83, Issue 8 https://doi.org/10.1021/acs.joc.8b00331	journal	April 2018
Site-Selective Conversion of Azido Groups at Carbonyl α-Positions to Diazo Groups in Diazido and Triazido Compounds Yokoi, Taiki; Tanimoto, Hiroki; Ueda, Tomomi The Journal of Organic Chemistry, Vol. 83, Issue 19 https://doi.org/10.1021/acs.joc.8b02074	journal	September 2018
Epimerization-Free Preparation of C-Terminal Cys Peptide Acid by Fmoc SPPS Using Pseudoproline-Type Protecting Group Tsuda, Shugo; Masuda, Shun; Yoshiya, Taku The Journal of Organic Chemistry, Vol. 85, Issue 3 https://doi.org/10.1021/acs.joc.9b02344	journal	October 2019
Octreotide-Mediated Tumor-Targeted Drug Delivery via a Cleavable Doxorubicin–Peptide Conjugate Lelle, Marco; Kaloyanova, Stefka; Freidel, Christoph Molecular Pharmaceutics, Vol. 12, Issue 12 https://doi.org/10.1021/acs.molpharmaceut.5b00487	journal	November 2015
Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy Sun, Bingjun; Luo, Cong; Yu, Han Nano Letters, Vol. 18, Issue 6 https://doi.org/10.1021/acs.nanolett.8b00737	journal	May 2018
Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey Albericio, Fernando; El-Faham, Ayman Organic Process Research & Development, Vol. 22, Issue 7 https://doi.org/10.1021/acs.oprd.8b00159	journal	June 2018
Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides Lelièvre, Dominique; Terrier, Victor P.; Delmas, Agnès F. Organic Letters, Vol. 18, Issue 5 https://doi.org/10.1021/acs.orglett.5b03612	journal	February 2016
Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives Dai, Yuanwei; Weng, Jiaping; George, Justin Organic Letters, Vol. 21, Issue 10 https://doi.org/10.1021/acs.orglett.9b01294	journal	May 2019
Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core Sharma, Anamika; Sheyi, Rotimi; Kumar, Ashish Organic Letters, Vol. 21, Issue 19 https://doi.org/10.1021/acs.orglett.9b02878	journal	September 2019
Single-Fluorophore Single-Chain Nanoparticle Undergoes Fluorophore-Driven Assembly with Fluorescence Features Retained in Physiological Milieu Liu, Sijia; Rong, Jie; Liu, Rui ACS Applied Polymer Materials, Vol. 3, Issue 4 https://doi.org/10.1021/acsapm.0c01313	journal	March 2021
Modulation of Innate Immune Responses via Covalently Linked TLR Agonists Tom, Janine K.; Dotsey, Emmanuel Y.; Wong, Hollie Y. ACS Central Science, Vol. 1, Issue 8 https://doi.org/10.1021/acscentsci.5b00274	journal	October 2015
Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses Albin, Tyler J.; Tom, Janine K.; Manna, Saikat ACS Central Science, Vol. 5, Issue 7 https://doi.org/10.1021/acscentsci.8b00823	journal	June 2019
Synthesis, Characterization, and Activity of a Triazine Bridged Antioxidant Small Molecule Gonzalez, Paulina; Pota, Kristof; Turan, Lara Su ACS Chemical Neuroscience, Vol. 8, Issue 11 https://doi.org/10.1021/acschemneuro.7b00184	journal	August 2017
Enzyme-Specific Doxorubicin Drug Beacon as Drug-Resistant Theranostic Molecular Probes Lock, Lye Lin; Tang, Zidu; Keith, Daniel ACS Macro Letters, Vol. 4, Issue 5 https://doi.org/10.1021/acsmacrolett.5b00170	journal	April 2015
Quinone-Methide Species, A Gateway to Functional Molecular Systems: From Self-Immolative Dendrimers to Long-Wavelength Fluorescent Dyes Gnaim, Samer; Shabat, Doron Accounts of Chemical Research, Vol. 47, Issue 10 https://doi.org/10.1021/ar500179y	journal	September 2014
Synthetic Routes to meso -Patterned Porphyrins Lindsey, Jonathan S. Accounts of Chemical Research, Vol. 43, Issue 2 https://doi.org/10.1021/ar900212t	journal	February 2010
Probing Electronic Communication in Covalently Linked Multiporphyrin Arrays. A Guide to the Rational Design of Molecular Photonic Devices Holten, Dewey; Bocian, David F.; Lindsey, Jonathan S. Accounts of Chemical Research, Vol. 35, Issue 1 https://doi.org/10.1021/ar970264z	journal	January 2002
Capture of Peptides with N-Terminal Serine and Threonine: A Sequence-Specific Chemical Method for Peptide Mixture Simplification Chelius, Dirk; Shaler, Thomas A. Bioconjugate Chemistry, Vol. 14, Issue 1 https://doi.org/10.1021/bc025605u	journal	January 2003
Near-Infrared Fluorescent RGD Peptides for Optical Imaging of Integrin α _v β ₃ Expression in Living Mice Cheng, Zhen; Wu, Yun; Xiong, Zhengming Bioconjugate Chemistry, Vol. 16, Issue 6 https://doi.org/10.1021/bc0501698	journal	October 2005
A Molecular Umbrella Approach to the Intracellular Delivery of Small Interfering RNA Cline, Lauren L.; Janout, Vaclav; Fisher, Michael Bioconjugate Chemistry, Vol. 22, Issue 11 https://doi.org/10.1021/bc200347x	journal	November 2011
Synthesis and Evaluation of a Peptide Targeted Small Molecular Gd-DOTA Monoamide Conjugate for MR Molecular Imaging of Prostate Cancer Wu, Xueming; Burden-Gulley, Susan M.; Yu, Guan-Ping Bioconjugate Chemistry, Vol. 23, Issue 8 https://doi.org/10.1021/bc300009t	journal	July 2012
α-Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation El-Mahdi, Ouafâa; Melnyk, Oleg Bioconjugate Chemistry, Vol. 24, Issue 5 https://doi.org/10.1021/bc300516f	journal	April 2013
Stepwise Orthogonal Click Chemistry toward Fabrication of Paclitaxel/Galactose Functionalized Fluorescent Nanoparticles for HepG2 Cell Targeting and Delivery Lai, Chian-Hui; Chang, Tsung-Che; Chuang, Yung-Jen Bioconjugate Chemistry, Vol. 24, Issue 10 https://doi.org/10.1021/bc400219t	journal	September 2013
Triazine-Based Tool Box for Developing Peptidic PET Imaging Probes: Syntheses, Microfluidic Radiolabeling, and Structure–Activity Evaluation Li, Hairong; Zhou, Haiying; Krieger, Stephanie Bioconjugate Chemistry, Vol. 25, Issue 4 https://doi.org/10.1021/bc500034n	journal	March 2014
Development of Protein-Binding Bifunctional Linkers for a New Generation of Dual-Acting Prodrugs Ajaj, Khalid Abu; Biniossek, Martin L.; Kratz, Felix Bioconjugate Chemistry, Vol. 20, Issue 2 https://doi.org/10.1021/bc800429q	journal	January 2009
Solid-Phase Synthesis and Kinetic Characterization of Fluorogenic Enzyme-Degradable Hydrogel Cross-linkers Moss, Jason A.; Stokols, Shula; Hixon, Mark S. Biomacromolecules, Vol. 7, Issue 4 https://doi.org/10.1021/bm051001s	journal	April 2006
Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors Fuwa, Haruhiko; Takahashi, Yasuko; Konno, Yu ACS Chemical Biology, Vol. 2, Issue 6 https://doi.org/10.1021/cb700073y	journal	May 2007
Polymeric Conjugates for Drug Delivery Larson, Nate; Ghandehari, Hamidreza Chemistry of Materials, Vol. 24, Issue 5 https://doi.org/10.1021/cm2031569	journal	December 2011
A survey of Hammett substituent constants and resonance and field parameters Hansch, Corwin.; Leo, A.; Taft, R. W. Chemical Reviews, Vol. 91, Issue 2 https://doi.org/10.1021/cr00002a004	journal	March 1991
Some New Trends in Chemical Graph Theory García-Domenech, Ramón; Gálvez, Jorge; de Julián-Ortiz, Jesus V. Chemical Reviews, Vol. 108, Issue 3 https://doi.org/10.1021/cr0780006	journal	March 2008
Molecular Imaging with PET Ametamey, Simon M.; Honer, Michael; Schubiger, Pius August Chemical Reviews, Vol. 108, Issue 5 https://doi.org/10.1021/cr0782426	journal	May 2008
Peptide Coupling Reagents, More than a Letter Soup El-Faham, Ayman; Albericio, Fernando Chemical Reviews, Vol. 111, Issue 11 https://doi.org/10.1021/cr100048w	journal	November 2011
Advances in Chemical Protein Modification Boutureira, Omar; Bernardes, Gonçalo J. L. Chemical Reviews, Vol. 115, Issue 5 https://doi.org/10.1021/cr500399p	journal	February 2015
Amino Acid-Protecting Groups Isidro-Llobet, Albert; Álvarez, Mercedes; Albericio, Fernando Chemical Reviews, Vol. 109, Issue 6 https://doi.org/10.1021/cr800323s	journal	June 2009
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging Kobayashi, Hisataka; Ogawa, Mikako; Alford, Raphael Chemical Reviews, Vol. 110, Issue 5 https://doi.org/10.1021/cr900263j	journal	May 2010
Multimodality Imaging Probes: Design and Challenges Louie, Angelique Chemical Reviews, Vol. 110, Issue 5 https://doi.org/10.1021/cr9003538	journal	May 2010
Synthesis and Physicochemical Properties of Metallobacteriochlorins Chen, Chih-Yuan; Sun, Erjun; Fan, Dazhong Inorganic Chemistry, Vol. 51, Issue 17 https://doi.org/10.1021/ic301262k	journal	August 2012
Preparation and Reactions of 2,6-Di-t-butylpyridine and Related Hindered Bases. A Case of Steric Hindrance toward the Proton ^1,2 Brown, Herbert C.; Kanner, Bernard Journal of the American Chemical Society, Vol. 88, Issue 5 https://doi.org/10.1021/ja00957a023	journal	March 1966
Cyanuric Chloride Derivatives. V. Reaction of Alkoxy-s-triazines and Aryloxy-s-triazines with Amines Thurston, Jack T.; Schaefer, Frederic C.; Dudley, James R. Journal of the American Chemical Society, Vol. 73, Issue 7 https://doi.org/10.1021/ja01151a005	journal	July 1951
Steric Effects on the Base Strengths of Cyclic Amines ¹ Hall, H. K. Journal of the American Chemical Society, Vol. 79, Issue 20 https://doi.org/10.1021/ja01577a031	journal	October 1957
A Modular Cross-Linking Approach for Exploring Protein Interactions Trester-Zedlitz, Michelle; Kamada, Katsuhiko; Burley, Stephen K. Journal of the American Chemical Society, Vol. 125, Issue 9 https://doi.org/10.1021/ja026917a	journal	March 2003
Structural Characterization of Modular Supramolecular Architectures in Solution Tiede, David M.; Zhang, Ruitian; Chen, Lin X. Journal of the American Chemical Society, Vol. 126, Issue 43 https://doi.org/10.1021/ja048209q	journal	November 2004
Probing Secondary Carbohydrate−Protein Interactions with Highly Dense Cyclodextrin-Centered Heteroglycoclusters: The Heterocluster Effect Gómez-García, Marta; Benito, Juan M.; Rodríguez-Lucena, David Journal of the American Chemical Society, Vol. 127, Issue 22 https://doi.org/10.1021/ja050934t	journal	June 2005
Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccine Candidates Ragupathi, Govind; Koide, Fusataka; Livingston, Philip O. Journal of the American Chemical Society, Vol. 128, Issue 8 https://doi.org/10.1021/ja057244+	journal	February 2006
Widely Useful DMAP-Catalyzed Esterification under Auxiliary Base- and Solvent-Free Conditions Sakakura, Akira; Kawajiri, Kimio; Ohkubo, Takuro Journal of the American Chemical Society, Vol. 129, Issue 47 https://doi.org/10.1021/ja075824w	journal	November 2007
Construction of a Photoactivatable Profluorescent Enzyme Via Propinquity Labeling Lee, Hsien-Ming; Xu, Weichen; Lawrence, David S. Journal of the American Chemical Society, Vol. 133, Issue 8 https://doi.org/10.1021/ja108950q	journal	March 2011
Multicolor, One- and Two-Photon Imaging of Enzymatic Activities in Live Cells with Fluorescently Quenched Activity-Based Probes (qABPs) Hu, Mingyu; Li, Lin; Wu, Hao Journal of the American Chemical Society, Vol. 133, Issue 31 https://doi.org/10.1021/ja200808y	journal	August 2011
Chemoenzymatic Reversible Immobilization and Labeling of Proteins without Prior Purification Rashidian, Mohammad; Song, James M.; Pricer, Rachel E. Journal of the American Chemical Society, Vol. 134, Issue 20 https://doi.org/10.1021/ja211308s	journal	May 2012
Iron Transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-Catecholate Siderophore–Aminopenicillin Conjugates Reveals Selectively Potent Antipseudomonal Activity Ji, Cheng; Miller, Patricia A.; Miller, Marvin J. Journal of the American Chemical Society, Vol. 134, Issue 24 https://doi.org/10.1021/ja303446w	journal	June 2012
Simultaneous Dual Protein Labeling Using a Triorthogonal Reagent Rashidian, Mohammad; Kumarapperuma, Sidath C.; Gabrielse, Kari Journal of the American Chemical Society, Vol. 135, Issue 44 https://doi.org/10.1021/ja403813b	journal	October 2013
In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides Weinstain, Roy; Savariar, Elamprakash N.; Felsen, Csilla N. Journal of the American Chemical Society, Vol. 136, Issue 3 https://doi.org/10.1021/ja411547j	journal	January 2014
Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment Kumar, Rajesh; Han, Jiyou; Lim, Hee-Joung Journal of the American Chemical Society, Vol. 136, Issue 51 https://doi.org/10.1021/ja510421q	journal	November 2014
Quenched Ligand-Directed Tosylate Reagents for One-Step Construction of Turn-On Fluorescent Biosensors Tsukiji, Shinya; Wang, Hangxiang; Miyagawa, Masayoshi Journal of the American Chemical Society, Vol. 131, Issue 25 https://doi.org/10.1021/ja902486c	journal	June 2009
Light-Mediated Spatial Control via Photolabile Fluorescently Quenched Peptide Cassettes Lee, Hsien-Ming; Priestman, Melanie A.; Lawrence, David S. Journal of the American Chemical Society, Vol. 132, Issue 5 https://doi.org/10.1021/ja907427p	journal	January 2010
Template-Directed Synthesis, Excited-State Photodynamics, and Electronic Communication in a Hexameric Wheel of Porphyrins Li, Junzhong; Ambroise, Arounaguiry; Yang, Sung Ik Journal of the American Chemical Society, Vol. 121, Issue 38 https://doi.org/10.1021/ja991730d	journal	September 1999
Targeting Heterogeneous Tumors Using a Multifunctional Molecular Prodrug Sharma, Amit; Lee, Min-Goo; Won, Miae Journal of the American Chemical Society, Vol. 141, Issue 39 https://doi.org/10.1021/jacs.9b07171	journal	September 2019
Synthesis and Pharmacological Evaluation of Fluorescent and Photoactivatable Analogues of Antiplasmodial Naphthylisoquinolines Bringmann, Gerhard; Gampe, Christian M.; Reichert, Yanina Journal of Medicinal Chemistry, Vol. 50, Issue 24 https://doi.org/10.1021/jm061464w	journal	November 2007
Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy Vineberg, Jacob G.; Zuniga, Edison S.; Kamath, Anushree Journal of Medicinal Chemistry, Vol. 57, Issue 13 https://doi.org/10.1021/jm500631u	journal	June 2014
Design, Synthesis, and Biological Evaluation of Theranostic Vitamin–Linker–Taxoid Conjugates Vineberg, Jacob G.; Wang, Tao; Zuniga, Edison S. Journal of Medicinal Chemistry, Vol. 58, Issue 5 https://doi.org/10.1021/jm5019115	journal	February 2015
Studies on the mechanism of transfer hydrogenation of nitro arenes by formate salts catalyzed by palladium/carbon Wiener, Harold; Blum, Jochanan; Sasson, Yoel The Journal of Organic Chemistry, Vol. 56, Issue 14 https://doi.org/10.1021/jo00014a029	journal	July 1991
The Reaction of Tertiary Amines with Halo-s-triazines and Halopyrimidines ^1a Kober, Ehrenfried; Rätz, Rudi The Journal of Organic Chemistry, Vol. 27, Issue 7 https://doi.org/10.1021/jo01054a049	journal	July 1962
Rational Syntheses of Cyclic Hexameric Porphyrin Arrays for Studies of Self-Assembling Light-Harvesting Systems Yu, Lianhe; Lindsey, Jonathan S. The Journal of Organic Chemistry, Vol. 66, Issue 22 https://doi.org/10.1021/jo010742q	journal	November 2001
Synthesis of Cyclic Hexameric Porphyrin Arrays. Anchors for Surface Immobilization and Columnar Self-Assembly Tomizaki, Kin-ya; Yu, Lianhe; Wei, Lingyun The Journal of Organic Chemistry, Vol. 68, Issue 21 https://doi.org/10.1021/jo034861c	journal	October 2003
Depsipeptide Methodology for Solid-Phase Peptide Synthesis: Circumventing Side Reactions and Development of an Automated Technique via Depsidipeptide Units ^† ^, ^‡ Coin, Irene; Dölling, Rudolf; Krause, Eberhard The Journal of Organic Chemistry, Vol. 71, Issue 16 https://doi.org/10.1021/jo060914p	journal	August 2006
Kondrat’eva Ligation: Diels–Alder-Based Irreversible Reaction for Bioconjugation Jouanno, Laurie-Anne; Chevalier, Arnaud; Sekkat, Nawal The Journal of Organic Chemistry, Vol. 79, Issue 21 https://doi.org/10.1021/jo501972m	journal	October 2014
Mechanisms, Pathways, and Dynamics of Excited-State Energy Flow in Self-Assembled Wheel-and-Spoke Light-Harvesting Architectures Song, Hee-eun; Kirmaier, Christine; Schwartz, Jennifer K. The Journal of Physical Chemistry B, Vol. 110, Issue 39 https://doi.org/10.1021/jp064000i	journal	September 2006
Effects of Multiple Pathways on Excited-State Energy Flow in Self-Assembled Wheel-and-Spoke Light-Harvesting Architectures Song, Hee-eun; Kirmaier, Christine; Schwartz, Jennifer K. The Journal of Physical Chemistry B, Vol. 110, Issue 39 https://doi.org/10.1021/jp064001a	journal	September 2006
Solution-State Conformational Ensemble of a Hexameric Porphyrin Array Characterized Using Molecular Dynamics and X-ray Scattering Mardis, Kristy L.; Sutton, Heather M.; Zuo, Xiaobing The Journal of Physical Chemistry A, Vol. 113, Issue 11 https://doi.org/10.1021/jp808318x	journal	February 2009
Reactive Compatibilization of Poly( l -lactide) and Conjugated Soybean Oil Gramlich, William M.; Robertson, Megan L.; Hillmyer, Marc A. Macromolecules, Vol. 43, Issue 5 https://doi.org/10.1021/ma902449x	journal	February 2010
Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents Jeffrey, Scott C.; De Brabander, Jef; Miyamoto, Jamie ACS Medicinal Chemistry Letters, Vol. 1, Issue 6 https://doi.org/10.1021/ml100039h	journal	June 2010
Chemically Self-Assembled Antibody Nanostructures as Potential Drug Carriers Fegan, Adrian; Kumarapperuma, Sidath C.; Wagner, Carston R. Molecular Pharmaceutics, Vol. 9, Issue 11 https://doi.org/10.1021/mp300303k	journal	October 2012
A Self-Assembled Light-Harvesting Array of Seven Porphyrins in a Wheel and Spoke Architecture Ambroise, Arounaguiry; Li, Junzhong; Yu, Lianhe Organic Letters, Vol. 2, Issue 17 https://doi.org/10.1021/ol006036d	journal	August 2000
Chemoselective Building Blocks for Dendrimers from Relative Reactivity Data Steffensen, Mackay B.; Simanek, Eric E. Organic Letters, Vol. 5, Issue 13 https://doi.org/10.1021/ol0347491	journal	June 2003
Synthesis and Self-Assembly of Functionalized Donor−σ−Acceptor Molecules Li, Hengfeng; Homan, Edwin A.; Lampkins, Andrew J. Organic Letters, Vol. 7, Issue 3 https://doi.org/10.1021/ol047597y	journal	February 2005
Efficient Solid-Phase Synthesis of Trifunctional Probes and Their Application to the Detection of Carbohydrate-Binding Proteins Lee, Myung-ryul; Jung, Da-Woon; Williams, Darren Organic Letters, Vol. 7, Issue 24 https://doi.org/10.1021/ol0523188	journal	November 2005
A Novel Acid-Catalyzed O -Benzylating Reagent with the Smallest Unit of Imidate Structure Yamada, Kohei; Fujita, Hikaru; Kunishima, Munetaka Organic Letters, Vol. 14, Issue 19 https://doi.org/10.1021/ol302222p	journal	September 2012
Acid-Labile Cys-Protecting Groups for the Fmoc/ t Bu Strategy: Filling the Gap Góngora-Benítez, Miriam; Mendive-Tapia, Lorena; Ramos-Tomillero, Iván Organic Letters, Vol. 14, Issue 21 https://doi.org/10.1021/ol302550p	journal	October 2012
Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes Chevalier, Arnaud; Hardouin, Julie; Renard, Pierre-Yves Organic Letters, Vol. 15, Issue 23 https://doi.org/10.1021/ol402972y	journal	November 2013
Benzotrifuranone: Synthesis, Structure, and Access to Polycyclic Heteroaromatics Li, Yan; Lampkins, Andrew J.; Baker, Matthew B. Organic Letters, Vol. 11, Issue 19 https://doi.org/10.1021/ol901631n	journal	October 2009
A Scalable Synthesis of Meso-Substituted Dipyrromethanes Laha, Joydev K.; Dhanalekshmi, Savithri; Taniguchi, Masahiko Organic Process Research & Development, Vol. 7, Issue 6 https://doi.org/10.1021/op034083q	journal	November 2003
Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals Dunetz, Joshua R.; Magano, Javier; Weisenburger, Gerald A. Organic Process Research & Development, Vol. 20, Issue 2 https://doi.org/10.1021/op500305s	journal	March 2015
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction Lang, Kathrin; Davis, Lloyd; Torres-Kolbus, Jessica Nature Chemistry, Vol. 4, Issue 4 https://doi.org/10.1038/nchem.1250	journal	February 2012
Selective chemical protein modification Spicer, Christopher D.; Davis, Benjamin G. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5740	journal	September 2014
Tumor angiogenesis: molecular pathways and therapeutic targets Weis, Sara M.; Cheresh, David A. Nature Medicine, Vol. 17, Issue 11 https://doi.org/10.1038/nm.2537	journal	November 2011
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases Hu, Jialiang; Van den Steen, Philippe E.; Sang, Qing-Xiang A. Nature Reviews Drug Discovery, Vol. 6, Issue 6 https://doi.org/10.1038/nrd2308	journal	June 2007
Matrix metalloproteinases and the regulation of tissue remodelling Page-McCaw, Andrea; Ewald, Andrew J.; Werb, Zena Nature Reviews Molecular Cell Biology, Vol. 8, Issue 3 https://doi.org/10.1038/nrm2125	journal	March 2007
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury Huang, Jiaguo; Li, Jingchao; Lyu, Yan Nature Materials, Vol. 18, Issue 10 https://doi.org/10.1038/s41563-019-0378-4	journal	May 2019
Rapid and efficient protein synthesis through expansion of the native chemical ligation concept Kulkarni, Sameer S.; Sayers, Jessica; Premdjee, Bhavesh Nature Reviews Chemistry, Vol. 2, Issue 4 https://doi.org/10.1038/s41570-018-0122	journal	March 2018
Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers Dou, Xuebo; Nomoto, Takahiro; Takemoto, Hiroyasu Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-26593-0	journal	May 2018
Amide bond formation: beyond the myth of coupling reagents Valeur, Eric; Bradley, Mark Chem. Soc. Rev., Vol. 38, Issue 2 https://doi.org/10.1039/B701677H	journal	January 2009
Soluble precipitable porphyrins for use in targeted molecular brachytherapy Yao, Zhen; Borbas, K. Eszter; Lindsey, Jonathan S. New J. Chem., Vol. 32, Issue 3 https://doi.org/10.1039/B714127K	journal	January 2008
Vinyl sulfone: a versatile function for simple bioconjugation and immobilization Morales-Sanfrutos, Julia; Lopez-Jaramillo, Javier; Ortega-Muñoz, Mariano Org. Biomol. Chem., Vol. 8, Issue 3 https://doi.org/10.1039/B920576D	journal	January 2010
Self-immolative linkers in polymeric delivery systems Blencowe, Christopher A.; Russell, Andrew T.; Greco, Francesca Polym. Chem., Vol. 2, Issue 4 https://doi.org/10.1039/C0PY00324G	journal	January 2011
Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy Lai, Chian-Hui; Lin, Yu-Chuan; Chou, Fong-In Chem. Commun., Vol. 48, Issue 4 https://doi.org/10.1039/C1CC14447B	journal	January 2012
Click-enabled heterotrifunctional template for sequential bioconjugations Beal, David M.; Albrow, Victoria E.; Burslem, George Org. Biomol. Chem., Vol. 10, Issue 3 https://doi.org/10.1039/C1OB06398G	journal	January 2012
Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies Jiménez Blanco, José L.; Ortiz Mellet, Carmen; García Fernández, José M. Chem. Soc. Rev., Vol. 42, Issue 11 https://doi.org/10.1039/C2CS35219B	journal	January 2013
Multivalent glyco(cyclo)peptides Galan, M. Carmen; Dumy, Pascal; Renaudet, Olivier Chem. Soc. Rev., Vol. 42, Issue 11 https://doi.org/10.1039/C2CS35413F	journal	January 2013
A chemical “hub” for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry Yan, Xiaowen; Li, Zhaoxin; Liang, Yong Chem. Commun., Vol. 50, Issue 50 https://doi.org/10.1039/C3CC48460B	journal	January 2014
Matching chelators to radiometals for radiopharmaceuticals Price, Eric W.; Orvig, Chris Chem. Soc. Rev., Vol. 43, Issue 1 https://doi.org/10.1039/C3CS60304K	journal	January 2014
Targeted theranostic prodrugs based on an aggregation-induced emission (AIE) luminogen for real-time dual-drug tracking Yuan, Youyong; Kwok, Ryan T. K.; Zhang, Ruoyu Chem. Commun., Vol. 50, Issue 78 https://doi.org/10.1039/C4CC05255B	journal	January 2014
A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds Thomas, Baptiste; Fiore, Michele; Daskhan, Gour Chand Chemical Communications, Vol. 51, Issue 25 https://doi.org/10.1039/C4CC05451B	journal	January 2015
“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates Tang, Wen; Becker, Matthew L. Chem. Soc. Rev., Vol. 43, Issue 20 https://doi.org/10.1039/C4CS00139G	journal	January 2014
Polarity-tunable and wavelength-tunable bacteriochlorins bearing a single carboxylic acid or NHS ester. Use in a protein bioconjugation model system Jiang, Jianbing; Chen, Chih-Yuan; Zhang, Nuonuo New Journal of Chemistry, Vol. 39, Issue 1 https://doi.org/10.1039/C4NJ01340A	journal	January 2015
Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products Tsakos, Michail; Schaffert, Eva S.; Clement, Lise L. Natural Product Reports, Vol. 32, Issue 4 https://doi.org/10.1039/C4NP00106K	journal	January 2015
Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones Huang, Yi-Chao; Guan, Chao-Jian; Tan, Xiang-Long Organic & Biomolecular Chemistry, Vol. 13, Issue 5 https://doi.org/10.1039/C4OB02260B	journal	January 2015
A bivalent small molecule-drug conjugate directed against carbonic anhydrase IX can elicit complete tumour regression in mice Krall, N.; Pretto, F.; Neri, D. Chemical Science, Vol. 5, Issue 9 https://doi.org/10.1039/C4SC00685B	journal	January 2014
A dendritic β-galactosidase-responsive folate–monomethylauristatin E conjugate Alsarraf, Jérôme; Péraudeau, Elodie; Poinot, Pauline Chemical Communications, Vol. 51, Issue 87 https://doi.org/10.1039/C5CC05294G	journal	January 2015
Highly chemoselective ligation of thiol- and amino-peptides on a bromomaleimide core Ramesh, Suhas; Cherkupally, Prabhakar; Govender, Thavendran Chemical Communications, Vol. 52, Issue 11 https://doi.org/10.1039/C5CC09457G	journal	January 2016
Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation Koniev, Oleksandr; Wagner, Alain Chem. Soc. Rev., Vol. 44, Issue 15 https://doi.org/10.1039/C5CS00048C	journal	January 2015
The road to the synthesis of “difficult peptides” Paradís-Bas, Marta; Tulla-Puche, Judit; Albericio, Fernando Chemical Society Reviews, Vol. 45, Issue 3 https://doi.org/10.1039/C5CS00680E	journal	January 2016
Emerging trends in enzyme inhibition by multivalent nanoconstructs Kanfar, Nasreddine; Bartolami, Eline; Zelli, Renaud Organic & Biomolecular Chemistry, Vol. 13, Issue 39 https://doi.org/10.1039/C5OB01405K	journal	January 2015
Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update Haldón, Estela; Nicasio, M. Carmen; Pérez, Pedro J. Organic & Biomolecular Chemistry, Vol. 13, Issue 37 https://doi.org/10.1039/C5OB01457C	journal	January 2015
Organizing multivalency in carbohydrate recognition Müller, Christian; Despras, Guillaume; Lindhorst, Thisbe K. Chem. Soc. Rev., Vol. 45, Issue 11 https://doi.org/10.1039/C6CS00165C	journal	January 2016
Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species Chen, Xiaoqiang; Wang, Fang; Hyun, Ji Young Chem. Soc. Rev., Vol. 45, Issue 10 https://doi.org/10.1039/C6CS00192K	journal	January 2016
Site-selective incorporation and ligation of protein aldehydes Spears, Richard J.; Fascione, Martin A. Organic & Biomolecular Chemistry, Vol. 14, Issue 32 https://doi.org/10.1039/C6OB00778C	journal	January 2016
Dual modification of biomolecules Maruani, Antoine; Richards, Daniel A.; Chudasama, Vijay Organic & Biomolecular Chemistry, Vol. 14, Issue 26 https://doi.org/10.1039/C6OB01010E	journal	January 2016
A trifunctional linker suitable for conducting three orthogonal click chemistries in one pot Knall, Astrid-Caroline; Hollauf, Manuel; Saf, Robert Organic & Biomolecular Chemistry, Vol. 14, Issue 45 https://doi.org/10.1039/C6OB02182D	journal	January 2016
Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines Pifferi, Carlo; Berthet, Nathalie; Renaudet, Olivier Biomaterials Science, Vol. 5, Issue 5 https://doi.org/10.1039/C7BM00072C	journal	January 2017
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging Liu, Hong-Wen; Chen, Lanlan; Xu, Chengyan Chemical Society Reviews, Vol. 47, Issue 18 https://doi.org/10.1039/C7CS00862G	journal	January 2018
Synthesis of tri-functionalized MMP2 FRET probes using a chemo-selective and late-stage modification of unprotected peptides Oriana, Sean; Cai, Ye; Bode, Jeffrey W. Organic & Biomolecular Chemistry, Vol. 15, Issue 8 https://doi.org/10.1039/C7OB00150A	journal	January 2017
Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency Anami, Yasuaki; Xiong, Wei; Gui, Xun Organic & Biomolecular Chemistry, Vol. 15, Issue 26 https://doi.org/10.1039/C7OB01027C	journal	January 2017
Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies Arbour, Christine A.; Kondasinghe, Thilini D.; Saraha, Hasina Y. Chemical Science, Vol. 9, Issue 2 https://doi.org/10.1039/C7SC03553E	journal	January 2018
Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions Yoshida, Suguru; Kanno, Kimiyuki; Kii, Isao Chemical Communications, Vol. 54, Issue 30 https://doi.org/10.1039/C8CC01195H	journal	January 2018
Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold Yokoi, Taiki; Ueda, Tomomi; Tanimoto, Hiroki Chemical Communications, Vol. 55, Issue 13 https://doi.org/10.1039/C8CC09415B	journal	January 2019
Design of a multifunctionalizable BODIPY platform for the facile elaboration of a large series of gold( i )-based optical theranostics Pliquett, Jacques; Amor, Souheila; Ponce-Vargas, Miguel Dalton Transactions, Vol. 47, Issue 32 https://doi.org/10.1039/C8DT02364F	journal	January 2018
Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives Longin, Ondřej; Hezwani, Mohammed; van de Langemheen, Helmus Organic & Biomolecular Chemistry, Vol. 16, Issue 29 https://doi.org/10.1039/C8OB01104D	journal	January 2018
Stepwise triple-click functionalization of synthetic peptides Kovalová, Anna; Pohl, Radek; Vrabel, Milan Organic & Biomolecular Chemistry, Vol. 16, Issue 33 https://doi.org/10.1039/C8OB01617H	journal	January 2018
One-pot multi-segment condensation strategies for chemical protein synthesis Zuo, Chong; Zhang, Baochang; Yan, Bingjia Organic & Biomolecular Chemistry, Vol. 17, Issue 4 https://doi.org/10.1039/C8OB02610F	journal	January 2019
Expanding the “minimalist” small molecule tagging approach to different bioactive compounds Lang, Wenjie; Yuan, Chaonan; Zhu, Biwei Organic & Biomolecular Chemistry, Vol. 17, Issue 11 https://doi.org/10.1039/C8OB03175D	journal	January 2019
Small-molecule fluorescent probes and their design Fu, Yanhua; Finney, Nathaniel S. RSC Advances, Vol. 8, Issue 51 https://doi.org/10.1039/C8RA02297F	journal	January 2018
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates Walsh, Stephen J.; Omarjee, Soleilmane; Galloway, Warren R. J. D. Chemical Science, Vol. 10, Issue 3 https://doi.org/10.1039/C8SC04645J	journal	January 2019
Activatable cell–biomaterial interfacing with photo-caged peptides Lin, Yiyang; Mazo, Manuel M.; Skaalure, Stacey C. Chemical Science, Vol. 10, Issue 4 https://doi.org/10.1039/C8SC04725A	journal	January 2019
An innovative approach for the synthesis of dual modality peptide imaging probes based on the native chemical ligation approach Hawala, Ivan; De Rosa, Lucia; Aime, Silvio Chemical Communications, Vol. 56, Issue 24 https://doi.org/10.1039/C9CC09980H	journal	January 2020
A brief overview of metal complexes as nuclear imaging agents MacPherson, Douglas S.; Fung, Kimberly; Cook, Brendon E. Dalton Transactions, Vol. 48, Issue 39 https://doi.org/10.1039/C9DT03039E	journal	January 2019
Enzymatically triggered chromogenic cross-linking agents under physiological conditions Fujita, Hikaru; Dou, Jinghuai; Matsumoto, Nobuyuki New Journal of Chemistry, Vol. 44, Issue 3 https://doi.org/10.1039/C9NJ04126E	journal	January 2020
Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions Fujita, Hikaru; Zhang, Yunlong; Wu, Zhiyuan New Journal of Chemistry, Vol. 44, Issue 10 https://doi.org/10.1039/C9NJ06187H	journal	January 2020
Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy Zuo, Chao; Yan, Bing-Jia; Zhu, Han-Ying Organic & Biomolecular Chemistry, Vol. 17, Issue 23 https://doi.org/10.1039/C9OB01114E	journal	January 2019
Azabicyclic vinyl sulfones for residue-specific dual protein labelling Gil de Montes, Enrique; Jiménez-Moreno, Ester; Oliveira, Bruno L. Chemical Science, Vol. 10, Issue 16 https://doi.org/10.1039/C9SC00125E	journal	January 2019
Biomedical applications of copper-free click chemistry: in vitro , in vivo , and ex vivo Kim, Eunha; Koo, Heebeom Chemical Science, Vol. 10, Issue 34 https://doi.org/10.1039/C9SC03368H	journal	January 2019
XXXI.—Contributions to a knowledge of cyanuric derivatives Fries, Harold H. J. Chem. Soc., Trans., Vol. 49, Issue 0 https://doi.org/10.1039/CT8864900314	journal	January 1886
Carbohydrate supramolecular chemistry: beyond the multivalent effect González-Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José M. Chemical Communications, Vol. 56, Issue 39 https://doi.org/10.1039/D0CC01135E	journal	January 2020
Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations Yoshida, Suguru; Sakata, Yuki; Misawa, Yoshihiro Chemical Communications, Vol. 57, Issue 7 https://doi.org/10.1039/D0CC07789E	journal	January 2021
Aqueous solubilization of hydrophobic tetrapyrrole macrocycles by attachment to an amphiphilic single-chain nanoparticle (SCNP) Liu, Rui; Liu, Sijia; Hu, Gongfang New Journal of Chemistry, Vol. 44, Issue 48 https://doi.org/10.1039/D0NJ04413J	journal	January 2020
Greening the synthesis of peptide therapeutics: an industrial perspective Martin, Vincent; Egelund, Peter H. G.; Johansson, Henrik RSC Advances, Vol. 10, Issue 69 https://doi.org/10.1039/D0RA07204D	journal	January 2020
Conformational properties of short poly(oxyethylene) chains in water studied by IR spectroscopy Begum, Roksana; Hiroatsu Matsuura, and Journal of the Chemical Society, Faraday Transactions, Vol. 93, Issue 21 https://doi.org/10.1039/a703436i	journal	January 1997
Studies related to the design and synthesis of a molecular octal counter Gryko, Dorota; Li, Junzhong; Diers, James R. Journal of Materials Chemistry, Vol. 11, Issue 4 https://doi.org/10.1039/b008224o	journal	January 2001
Developing novel activity-based fluorescent probes that target different classes of proteasesElectronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b4/b404471a/ Zhu, Qing; Girish, Aparna; Chattopadhaya, Souvik Chemical Communications, Issue 13 https://doi.org/10.1039/b404471a	journal	January 2004
A new chemical probe for the detection of the cancer-linked galectin-3 Ballell, Lluis; van Scherpenzeel, Monique; Buchalova, Katerina Organic & Biomolecular Chemistry, Vol. 4, Issue 23 https://doi.org/10.1039/b611050a	journal	January 2006
A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation Clavé, Guillaume; Boutal, Hervé; Hoang, Antoine Organic & Biomolecular Chemistry, Vol. 6, Issue 17 https://doi.org/10.1039/b807263a	journal	January 2008
The azaquinone-methide elimination: comparison study of 1,6- and 1,4-eliminations under physiological conditions Erez, Rotem; Shabat, Doron Organic & Biomolecular Chemistry, Vol. 6, Issue 15 https://doi.org/10.1039/b808198k	journal	January 2008
Fluorescence quenched quinone methide based activity probes – a cautionary tale Sellars, Jonathan D.; Landrum, Marie; Congreve, Aileen Organic & Biomolecular Chemistry, Vol. 8, Issue 7 https://doi.org/10.1039/b920443a	journal	January 2010
Stirring the porphyrin alphabet soup—functionalization reactions for porphyrins Senge, Mathias O. Chemical Communications, Vol. 47, Issue 7 https://doi.org/10.1039/c0cc03984e	journal	January 2011
Access to functionalised silver(i) and gold(i) N-heterocyclic carbenes by [2 + 3] dipolar cycloadditions Hospital, Audrey; Gibard, Clémentine; Gaulier, Christelle Dalton Transactions, Vol. 41, Issue 22 https://doi.org/10.1039/c2dt30249g	journal	January 2012
Molecular multifunctionalization via electronically coupled lactones Baker, Matthew B.; Ghiviriga, Ion; Castellano, Ronald K. Chemical Science, Vol. 3, Issue 4 https://doi.org/10.1039/c2sc00943a	journal	January 2012
Robinson's landmark synthesis of tropinone Medley, Jonathan William; Movassaghi, Mohammad Chemical Communications, Vol. 49, Issue 92 https://doi.org/10.1039/c3cc44461a	journal	January 2013
Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme Knall, Astrid-Caroline; Slugovc, Christian Chemical Society Reviews, Vol. 42, Issue 12 https://doi.org/10.1039/c3cs60049a	journal	January 2013
The first “ready-to-use” benzene-based heterotrifunctional cross-linker for multiple bioconjugation Viault, Guillaume; Dautrey, Sébastien; Maindron, Nicolas Organic & Biomolecular Chemistry, Vol. 11, Issue 16 https://doi.org/10.1039/c3ob40086g	journal	January 2013
An enzyme-responsive system programmed for the double release of bioactive molecules through an intracellular chemical amplification process Grinda, Marion; Legigan, Thibaut; Clarhaut, Jonathan Organic & Biomolecular Chemistry, Vol. 11, Issue 41 https://doi.org/10.1039/c3ob41536h	journal	January 2013
115. Contributions to the chemistry of synthetic antimalarials. Part VI. Some derivatives of 1 : 3 : 5-triazine Cuthbertson, W. W.; Moffatt, J. S. Journal of the Chemical Society (Resumed) https://doi.org/10.1039/jr9480000561	journal	January 1948
697. Organic reactions in aqueous solution at room temperature. Part I. The influence of pH on condensations involving the linking of carbon to nitrogen and of carbon to carbon Haley, C. A. C.; Maitland, P. Journal of the Chemical Society (Resumed) https://doi.org/10.1039/jr9510003155	journal	January 1951
377. A kinetic study of the effect of substituents on the rate of formation of alkylpyridinium halides in nitromethane solution Clarke, K.; Rothwell, K. Journal of the Chemical Society (Resumed) https://doi.org/10.1039/jr9600001885	journal	January 1960
Restricted rotations in 4,6-bis- and 2,4,6-tris-(N,N-dialkylamino)-s-triazines Katritzky, Alan R.; Ghiviriga, Ion; Steel, Peter J. Journal of the Chemical Society, Perkin Transactions 2, Issue 3 https://doi.org/10.1039/p29960000443	journal	January 1996
The fluorescence quantum yield parameter in Förster resonance energy transfer (FRET)—Meaning, misperception, and molecular design Lindsey, Jonathan S.; Taniguchi, Masahiko; Bocian, David F. Chemical Physics Reviews, Vol. 2, Issue 1 https://doi.org/10.1063/5.0041132	journal	March 2021
Introducing the Azlactone Functionality into Polymers through Controlled Radical Polymerization: Strategies and Recent Developments Ho, H. T.; Levere, M. E.; Fournier, D. Australian Journal of Chemistry, Vol. 65, Issue 8 https://doi.org/10.1071/CH12192	journal	January 2012
Highly efficient reduction of nitro compounds: Recyclable Pd/C-catalyzed transfer hydrogenation with ammonium formate or hydrazine hydrate as hydrogen source Chen, Xia; Zhou, Xiao-Yu; Wu, Hong Synthetic Communications, Vol. 48, Issue 19 https://doi.org/10.1080/00397911.2018.1484924	journal	October 2018
Selective Mono- or Dialkoxylation of 2,4,6-Trichloro-1,3,5-triazine in Solid-Liquid Phase Transfer Conditions Menicagli, Rita; Malanga, Corrado; Peluso, Paola Synthetic Communications, Vol. 24, Issue 15 https://doi.org/10.1080/00397919408010229	journal	August 1994
[12]aneN ₃ -based multifunctional compounds as fluorescent probes and nucleic acids delivering agents Gao, Yong-Guang; Huangfu, Shu-Yuan; Patil, Suryaji Drug Delivery, Vol. 27, Issue 1 https://doi.org/10.1080/10717544.2019.1704943	journal	December 2019
Toll-Like Receptor Agonists: Are They Good Adjuvants? Gnjatic, Sacha; Sawhney, Nikhil B.; Bhardwaj, Nina The Cancer Journal, Vol. 16, Issue 4 https://doi.org/10.1097/PPO.0b013e3181eaca65	journal	January 2010
The 8 year thicket of triazine dendrimers: strategies, targets and applications Simanek, E. E.; Abdou, H.; Lalwani, S. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 466, Issue 2117, p. 1445-1468 https://doi.org/10.1098/rspa.2009.0108	journal	May 2009
Protease‐activated prodrugs: strategies, challenges, and future directions Poreba, Marcin The FEBS Journal, Vol. 287, Issue 10 https://doi.org/10.1111/febs.15227	journal	February 2020
Molecular Electronic Tuning of Photosensitizers to Enhance Photodynamic Therapy: Synthetic Dicyanobacteriochlorins as a Case Study Yang, Eunkyung; Diers, James R.; Huang, Ying-Ying Photochemistry and Photobiology, Vol. 89, Issue 3 https://doi.org/10.1111/php.12021	journal	January 2013
PhotochemCAD 3: Diverse Modules for Photophysical Calculations with Multiple Spectral Databases Taniguchi, Masahiko; Du, Hai; Lindsey, Jonathan S. Photochemistry and Photobiology, Vol. 94, Issue 2 https://doi.org/10.1111/php.12862	journal	February 2018
NanoSIMS for biological applications: Current practices and analyses Nuñez, Jamie; Renslow, Ryan; Cliff, John B. Biointerphases, Vol. 13, Issue 3 https://doi.org/10.1116/1.4993628	journal	June 2018
Peptide-based scaffolds for in vivo immobilization and enzyme attachment in therapeutic applications Lee, David L.; Chin, Hsiao-ling M.; Knudsen, Christopher G. Molecular and Nano Machines III https://doi.org/10.1117/12.2566895	conference	September 2020
Bioconjugatable synthetic chlorins rendered water-soluble with three PEG-12 groups via click chemistry Matsumoto, Nobuyuki; Taniguchi, Masahiko; Lindsey, Jonathan S. Journal of Porphyrins and Phthalocyanines, Vol. 24, Issue 01n03 https://doi.org/10.1142/S1088424619501219	journal	January 2020
Bimodal Imaging Probes for Combined PET and OI: Recent Developments and Future Directions for Hybrid Agent Development Seibold, Uwe; Wängler, Björn; Schirrmacher, Ralf BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/153741	journal	January 2014
Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity Albright, Charles F.; Graciani, Nilsa; Han, Wei Molecular Cancer Therapeutics, Vol. 4, Issue 5 https://doi.org/10.1158/1535-7163.MCT-05-0006	journal	May 2005
Antibody–Drug Conjugates: A Comprehensive Review Khongorzul, Puregmaa; Ling, Cai Jia; Khan, Farhan Ullah Molecular Cancer Research, Vol. 18, Issue 1 https://doi.org/10.1158/1541-7786.MCR-19-0582	journal	October 2019
The Significance of Cross-links in the Formation of Hapten-carrier Complexes Mayer, R. L. International Archives of Allergy and Immunology, Vol. 8, Issue 3 https://doi.org/10.1159/000228275	journal	January 1956
Photodynamic Therapy: Current Status and Future Directions Benov, Ludmil Medical Principles and Practice, Vol. 24, Issue s1 https://doi.org/10.1159/000362416	journal	January 2015
Synthetic carbohydrate-based vaccines: challenges and opportunities Mettu, Ravinder; Chen, Chiang-Yun; Wu, Chung-Yi Journal of Biomedical Science, Vol. 27, Issue 1 https://doi.org/10.1186/s12929-019-0591-0	journal	January 2020
Advances in redox-responsive drug delivery systems of tumor microenvironment Guo, Xiaoshuang; Cheng, Yuan; Zhao, Xiaotian Journal of Nanobiotechnology, Vol. 16, Issue 1 https://doi.org/10.1186/s12951-018-0398-2	journal	September 2018
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs) Murale, Dhiraj P.; Hong, Seong Cheol; Haque, Md. Mamunul Proteome Science, Vol. 15, Issue 1 https://doi.org/10.1186/s12953-017-0123-3	journal	December 2016
Functionalized Calix[4]resorcinarene Cavitands. Versatile Platforms for the Modular Construction of Extended Molecular Switches Azov, Vladimir A.; Schlegel, Anna; Diederich, François Bulletin of the Chemical Society of Japan, Vol. 79, Issue 12 https://doi.org/10.1246/bcsj.79.1926	journal	December 2006
Substituent Effects in 1, 3, 5-Triazine Derivatives Fukushima, Yoshiaki; Hashida, Yejl; Matsui, Kohji NIPPON KAGAKU KAISHI, Issue 3 https://doi.org/10.1246/nikkashi.1972.629	journal	January 1972
Racemization-Free Synthesis of C-Terminal Cysteine-Peptide Using 2-Chlorotrityl Resin. Fujiwara, Yoichi; Akaji, Kenichi; Kiso, Yoshiaki Chemical and Pharmaceutical Bulletin, Vol. 42, Issue 3 https://doi.org/10.1248/cpb.42.724	journal	January 1994
Studies on Synthesis of the Antibacterial Agent NM441. II. Selection of a Suitable Base for ALkylation of 1-Substituted Piperazine with 4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one. Fujii, Tatsuya; Nishida, Hiroshi; Abiru, Yoshiaki Chemical and Pharmaceutical Bulletin, Vol. 43, Issue 11 https://doi.org/10.1248/cpb.43.1872	journal	January 1995
Synthesis and Antiviral Activities of Some 2,4,6-Trisubstituted 1,3,5-Triazines Mibu, Nobuko; Yokomizo, Kazumi; Koga, Airi Chemical and Pharmaceutical Bulletin, Vol. 62, Issue 10 https://doi.org/10.1248/cpb.c14-00421	journal	January 2014
Synthesis and Antiviral Evaluation of Some C₃-Symmetrical Trialkoxy-Substituted 1,3,5-Triazines and Their Molecular Geometry Mibu, Nobuko; Yokomizo, Kazumi; Aki, Hatsumi CHEMICAL & PHARMACEUTICAL BULLETIN, Vol. 63, Issue 11 https://doi.org/10.1248/cpb.c15-00309	journal	January 2015
Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response McKeown, S. R. The British Journal of Radiology, Vol. 87, Issue 1035 https://doi.org/10.1259/bjr.20130676	journal	March 2014
Boron-dipyrromethene dyes for incorporation in synthetic multi-pigment light-harvesting arrays Wagner, R. W.; Lindsey, J. S. Pure and Applied Chemistry, Vol. 68, Issue 7 https://doi.org/10.1351/pac199668071373	journal	January 1996
Photodynamic therapy in cancer treatment - an update review Dos Santos, Anc��ly Ferreira; De Almeida, Daria Raquel Queiroz; Terra, Leticia Ferreira Journal of Cancer Metastasis and Treatment, Vol. 2019 https://doi.org/10.20517/2394-4722.2018.83	journal	January 2019
[1,3,5]-Triazine: A Versatile Heterocycle in Current Applications of Organic Chemistry Giacomelli, Giampaolo; Porcheddu, Andrea; Luca, Lidia Current Organic Chemistry, Vol. 8, Issue 15 https://doi.org/10.2174/1385272043369845	journal	October 2004
Melamine Derivatives - A Review on Synthesis and Application Bretterbauer, Klaus; Schwarzinger, Clemens Current Organic Synthesis, Vol. 9, Issue 3 https://doi.org/10.2174/157017912801270612	journal	May 2012
1,3,5-Triazine as core for the preparation of dendrons Sheyi, Rotimi; Sharma, Anamika; Kumar, Ashish Arkivoc, Vol. 2020, Issue 3 https://doi.org/10.24820/ark.5550190.p011.245	journal	August 2020
Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game Sharma, Anamika; El-Faham, Ayman; de la Torre, Beatriz G. Frontiers in Chemistry, Vol. 6 https://doi.org/10.3389/fchem.2018.00516	journal	November 2018
Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa Goyard, David; Thomas, Baptiste; Gillon, Emilie Frontiers in Chemistry, Vol. 7 https://doi.org/10.3389/fchem.2019.00666	journal	October 2019
Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy Kirtland, Max E.; Tsitoura, Daphne C.; Durham, Stephen R. Frontiers in Immunology, Vol. 11 https://doi.org/10.3389/fimmu.2020.599083	journal	November 2020
Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making Debie, Pieterjan; Hernot, Sophie Frontiers in Pharmacology, Vol. 10 https://doi.org/10.3389/fphar.2019.00510	journal	May 2019
Native Chemical Ligation: A Boon to Peptide Chemistry Thapa, Parashar; Zhang, Rui-Yang; Menon, Vinay Molecules, Vol. 19, Issue 9 https://doi.org/10.3390/molecules190914461	journal	September 2014
Functionalization of a Triazine Dendrimer Presenting Four Maleimides on the Periphery and a DOTA Group at the Core Lee, Changsuk; Ji, Kun; Simanek, Eric Molecules, Vol. 21, Issue 3 https://doi.org/10.3390/molecules21030335	journal	March 2016
Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests Molina, Noemi; Martin-Serrano, Angela; Fernandez, Tahia Molecules, Vol. 23, Issue 5 https://doi.org/10.3390/molecules23050997	journal	April 2018
A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand Bundle, David; Paszkiewicz, Eugenia; Elsaidi, Hassan Molecules, Vol. 23, Issue 8 https://doi.org/10.3390/molecules23081961	journal	August 2018
Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety He, Rongjun; Finan, Brian; Mayer, John P. Molecules, Vol. 24, Issue 10 https://doi.org/10.3390/molecules24101855	journal	May 2019
Design, Synthesis, In Vitro, and Initial In Vivo Evaluation of Heterobivalent Peptidic Ligands Targeting Both NPY(Y1)- and GRP-Receptors—An Improvement for Breast Cancer Imaging? Vall-Sagarra, Alicia; Litau, Shanna; Decristoforo, Clemens Pharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.3390/ph11030065	journal	July 2018
Micellar Organocatalysis Using Smart Polymer Supports: Influence of Thermoresponsive Self-Assembly on Catalytic Activity Yu, Xiaoqian; Herberg, Artjom; Kuckling, Dirk Polymers, Vol. 12, Issue 10 https://doi.org/10.3390/polym12102265	journal	October 2020
Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii Gilkes, Adrienne P.; Albin, Tyler J.; Manna, Saikat The Journal of Immunology, Vol. 204, Issue 3 https://doi.org/10.4049/jimmunol.1900991	journal	December 2019
Reactivities of Cyanuric Chloride Derivatives. II Goi, Mituhiro Journal of Synthetic Organic Chemistry, Japan, Vol. 18, Issue 5 https://doi.org/10.5059/yukigoseikyokaishi.18.332	journal	January 1960
Reactivities of Cyanuric Chloride Derivatives II Goi, Mituhiro Journal of Synthetic Organic Chemistry, Japan, Vol. 18, Issue 5 https://doi.org/10.5059/yukigoseikyokaishi.18.337	journal	January 1960
Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy Song, Xinyu; Han, Xiaoyue; Yu, Fabiao Theranostics, Vol. 8, Issue 8 https://doi.org/10.7150/thno.24041	journal	January 2018
Theranostics based on AIEgens Wang, Dong; Lee, Michelle Mei Suet; Xu, Wenhan Theranostics, Vol. 8, Issue 18 https://doi.org/10.7150/thno.27787	journal	January 2018
Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging Chen, Peiyao; Kuang, Wen; Zheng, Zhen Theranostics, Vol. 9, Issue 24 https://doi.org/10.7150/thno.37625	journal	January 2019
Protease-Activated Drug Development Choi, Ki Young; Swierczewska, Magdalena; Lee, Seulki Theranostics, Vol. 2, Issue 2 https://doi.org/10.7150/thno.4068	journal	January 2012
Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe Zhu, Lei; Guo, Ning; Li, Quanzheng Theranostics, Vol. 2, Issue 8 https://doi.org/10.7150/thno.4762	journal	January 2012
Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer Shi, Jiyun; Liu, Tracy W. B.; Chen, Juan Theranostics, Vol. 1 https://doi.org/10.7150/thno/v01p0363	journal	January 2011

Similar Records

Rigid, well-defined block copolymers for efficient light harvesting

Journal Article · 1994 · Journal of the American Chemical Society; (United States) · OSTI ID:6914726

Watkins, D M; Fox, M A

Self-assembling hydrogel scaffolds for photocatalytic hydrogen production

Journal Article · 2014 · Nature Chemistry · OSTI ID:1162321

Weingarten, Adam S.; Kazantsev, Roman V.; Palmer, Liam C.; +6 more

Beyond green with synthetic chlorophylls – Connecting structural features with spectral properties

Journal Article · 2022 · Journal of Photochemistry and Photobiology C: Photochemistry Reviews · OSTI ID:1977387

Taniguchi, Masahiko; Bocian, David F.; Holten, Dewey; +1 more

Title: Design, Synthesis, and Utility of Defined Molecular Scaffolds

Citation Formats

References (332)

Similar Records

Related Subjects