Nanofabrication of silicon surfaces for reduced virus adhesion
Abstract
Nanofabrication is a remarkably effective technique to create desirable nanoscale patterns. In this work, the effect of surface nanofabrication on altering virus adhesion to the substrates was examined. Arrays of nanoholes, 50 nm in diameter, 22 nm deep, and 100 nm in pitch distance, were created on silicon (Si) wafers by electron-beam lithography and reactive ion etching. MS2 coliphage, which is 26 ± 2 nm in diameter and is frequently used as a surrogate for human viruses, was applied to investigate the interaction between the virions and smooth or nanostructured Si surfaces. Scanning electron microscopy and atomic force microscopy along with surface wettability analyses revealed that the nanofabrication had the effect of reducing not only the number of viruses attached but also the strength of virus adhesion. These effects were ascribed to the presence of nanoholes, which were inaccessible to the virions due to the unique surface topographical parameters and the surface chemistry, resulting in the decrease of the overall solid contact area for MS2 attachment. The periodic spacing of the nanoholes also limited the unit landing area for MS2 particles, restricting the formation of MS2 aggregates and leading to the reduced amount of MS2 attachment. We anticipate that smart design of a surface’s chemical compositionmore »
- Authors:
-
- Illinois Institute of Technology, Chicago, IL (United States)
- U.S. Food and Drug Administration (FDA), Bedford Park, IL (United States)
- Argonne National Lab. (ANL), Argonne, IL (United States). Center for Nanoscale Materials
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; U.S. Food and Drug Administration (FDA)
- OSTI Identifier:
- 1798301
- Alternate Identifier(s):
- OSTI ID: 1755785
- Grant/Contract Number:
- AC02-06CH11357; FDA-CFSAN-IF01673
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Vacuum Science and Technology B
- Additional Journal Information:
- Journal Volume: 39; Journal Issue: 1; Journal ID: ISSN 2166-2746
- Publisher:
- American Vacuum Society / AIP
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; nanofabrication; electron-beam lithography; virus adhesion; surface topography; atomic force microscopy
Citation Formats
Guo, Ao, Shieh, Y. Carol, Divan, Ralu, and Wang, Rong R. Nanofabrication of silicon surfaces for reduced virus adhesion. United States: N. p., 2021.
Web. doi:10.1116/6.0000548.
Guo, Ao, Shieh, Y. Carol, Divan, Ralu, & Wang, Rong R. Nanofabrication of silicon surfaces for reduced virus adhesion. United States. https://doi.org/10.1116/6.0000548
Guo, Ao, Shieh, Y. Carol, Divan, Ralu, and Wang, Rong R. Tue .
"Nanofabrication of silicon surfaces for reduced virus adhesion". United States. https://doi.org/10.1116/6.0000548. https://www.osti.gov/servlets/purl/1798301.
@article{osti_1798301,
title = {Nanofabrication of silicon surfaces for reduced virus adhesion},
author = {Guo, Ao and Shieh, Y. Carol and Divan, Ralu and Wang, Rong R.},
abstractNote = {Nanofabrication is a remarkably effective technique to create desirable nanoscale patterns. In this work, the effect of surface nanofabrication on altering virus adhesion to the substrates was examined. Arrays of nanoholes, 50 nm in diameter, 22 nm deep, and 100 nm in pitch distance, were created on silicon (Si) wafers by electron-beam lithography and reactive ion etching. MS2 coliphage, which is 26 ± 2 nm in diameter and is frequently used as a surrogate for human viruses, was applied to investigate the interaction between the virions and smooth or nanostructured Si surfaces. Scanning electron microscopy and atomic force microscopy along with surface wettability analyses revealed that the nanofabrication had the effect of reducing not only the number of viruses attached but also the strength of virus adhesion. These effects were ascribed to the presence of nanoholes, which were inaccessible to the virions due to the unique surface topographical parameters and the surface chemistry, resulting in the decrease of the overall solid contact area for MS2 attachment. The periodic spacing of the nanoholes also limited the unit landing area for MS2 particles, restricting the formation of MS2 aggregates and leading to the reduced amount of MS2 attachment. We anticipate that smart design of a surface’s chemical composition and nanostructure will offer a feasible solution to improve mitigations for controlling viral adhesion and transmission to and from food contact surfaces.},
doi = {10.1116/6.0000548},
journal = {Journal of Vacuum Science and Technology B},
number = 1,
volume = 39,
place = {United States},
year = {Tue Jan 05 00:00:00 EST 2021},
month = {Tue Jan 05 00:00:00 EST 2021}
}
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