Modulating the Molecular Geometry and Solution Self-Assembly of Amphiphilic Polypeptoid Block Copolymers by Side Chain Branching Pattern

Kang, Liying; Chao, Albert; Zhang, Meng; Yu, Tianyi; Wang, Jun; Wang, Qi; Yu, Huihui; Jiang, Naisheng; Zhang, Donghui

doi:10.1021/jacs.1c01088

Title: Modulating the Molecular Geometry and Solution Self-Assembly of Amphiphilic Polypeptoid Block Copolymers by Side Chain Branching Pattern

Journal Article · 06 April 2021 · Journal of the American Chemical Society

DOI: https://doi.org/10.1021/jacs.1c01088 · OSTI ID:1783968

Kang, Liying ^[1]; Chao, Albert ^[2];

^[2]; Yu, Tianyi ^[2]; Wang, Jun ^[1]; Wang, Qi ^[1]; Yu, Huihui ^[1];

^[3];

^[2]

Univ. of Science and Technology Beijing (China)
Louisiana State Univ., Baton Rouge, LA (United States)
Univ. of Science and Technology Beijing (China); Louisiana State Univ., Baton Rouge, LA (United States)

Solution self-assembly of coil-crystalline diblock copolypeptoids has attracted increasing attention due to its capability to form hierarchical nanostructures with tailorable morphologies and functionalities. While the N-substituent (or side chain) structures are known to affect the crystallization of polypeptoids, their roles in dictating the hierarchical solution self-assembly of diblock copolypeptoids are not fully understood. Herein, we designed and synthesized two types of diblock copolypeptoids, i.e., poly(N-methylglycine)-b-poly(N-octylglycine) (PNMG-b-PNOG) and poly(N-methylglycine)-b-poly(N-2-ethyl-1-hexylglycine) (PNMG-b-PNEHG), to investigate the influence of N-substituent structure on the crystalline packing and hierarchical self-assembly of diblock copolypeptoids in methanol. With a linear aliphatic N-substituent, the PNOG blocks pack into a highly ordered crystalline structure with a board-like molecular geometry, resulting in the self-assembly of PNMG-b-PNOG molecules into a hierarchical microflower morphology composed of radially arranged nanoribbon subunits. By contrast, the PNEHG blocks bearing bulky branched aliphatic N-substituents are rod-like and prefer to stack into a columnar hexagonal liquid crystalline mesophase, which drives PNMG-b-PNEHG molecules to self-assemble into symmetrical hexagonal nanosheets in solution. A combination of time-dependent small/wide-angle X-ray scattering and microscopic imaging analysis further revealed the self-assembly mechanisms for the formation of these microflowers and hexagonal nanosheets. These results highlight the significant impact of the N-substituent architecture (i.e., linear versus branched) on the supramolecular self-assembly of diblock copolypeptoids in solution, which can serve as an effective strategy to tune the geometry and hierarchical structure of polypeptoid-based nanomaterials.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States); Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; National Institutes of Health, National Institute of General Medical Sciences; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0012704; AC02-06CH11357; P41 GM111244; S10 OD012331

OSTI ID:: 1783968

Alternate ID(s):: OSTI ID: 1786004

Report Number(s):: BNL-221499-2021-JACI

Journal Information:: Journal of the American Chemical Society, Vol. 143, Issue 15; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (68)

Cyclic Poly(α-peptoid)s and Their Block Copolymers from N-Heterocyclic Carbene-Mediated Ring-Opening Polymerizations of N-Substituted N -Carboxylanhydrides Guo, Li; Zhang, Donghui Journal of the American Chemical Society, Vol. 131, Issue 50 https://doi.org/10.1021/ja907380d	journal	December 2009
Form factors of block copolymer micelles with spherical, ellipsoidal and cylindrical cores Pedersen, Jan Skov Journal of Applied Crystallography, Vol. 33, Issue 3 https://doi.org/10.1107/S0021889899012248	journal	June 2000
Two-Dimensional Self-Assembled Structures of Highly Ordered Bioactive Crystalline-Based Block Copolymers Ganda, Sylvia; Dulle, Martin; Drechsler, Markus Macromolecules, Vol. 50, Issue 21 https://doi.org/10.1021/acs.macromol.7b01453	journal	October 2017
Morphology and Proton Transport in Humidified Phosphonated Peptoid Block Copolymers Sun, Jing; Jiang, Xi; Siegmund, Aaron Macromolecules, Vol. 49, Issue 8 https://doi.org/10.1021/acs.macromol.6b00353	journal	April 2016
Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles Sun, Jing; Jiang, Xi; Lund, Reidar Proceedings of the National Academy of Sciences, Vol. 113, Issue 15 https://doi.org/10.1073/pnas.1517169113	journal	March 2016
Crystallization and Melting Behaviors of Cyclic and Linear Polypeptoids with Alkyl Side Chains Lee, Chang-Uk; Li, Ang; Ghale, Kushal Macromolecules, Vol. 46, Issue 20 https://doi.org/10.1021/ma401067f	journal	October 2013
Crystallization in Sequence-Defined Peptoid Diblock Copolymers Induced by Microphase Separation Sun, Jing; Teran, Alexander A.; Liao, Xunxun Journal of the American Chemical Society, Vol. 136, Issue 5 https://doi.org/10.1021/ja412123y	journal	January 2014
Multidimensional hierarchical self-assembly of amphiphilic cylindrical block comicelles Qiu, H.; Hudson, Z. M.; Winnik, M. A. Science, Vol. 347, Issue 6228 https://doi.org/10.1126/science.1261816	journal	March 2015
Supramolecular Nanosheets Assembled from Poly(ethylene glycol)- b -poly( N -(2-phenylethyl)glycine) Diblock Copolymer Containing Crystallizable Hydrophobic Polypeptoid: Crystallization Driven Assembly Transition from Filaments to Nanosheets Wei, Yuhan; Tian, Jiliang; Zhang, Zekun Macromolecules, Vol. 52, Issue 4 https://doi.org/10.1021/acs.macromol.8b02230	journal	February 2019
Universal Relationship between Molecular Structure and Crystal Structure in Peptoid Polymers and Prevalence of the cis Backbone Conformation Greer, Douglas R.; Stolberg, Michael A.; Kundu, Joyjit Journal of the American Chemical Society, Vol. 140, Issue 2 https://doi.org/10.1021/jacs.7b11891	journal	January 2018
Polypeptoid polymers: Synthesis, characterization, and properties Chan, Brandon A.; Xuan, Sunting; Li, Ang Biopolymers, Vol. 109, Issue 1 https://doi.org/10.1002/bip.23070	journal	October 2017
Crystallization-Driven Self-Assembly of Metallo-Polyelectrolyte Block Copolymers with a Polycaprolactone Core-Forming Segment Cha, Yujin; Jarrett-Wilkins, Charles; Rahman, Md Anisur ACS Macro Letters, Vol. 8, Issue 7 https://doi.org/10.1021/acsmacrolett.9b00335	journal	June 2019
Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications Birke, Alexander; Ling, Jun; Barz, Matthias Progress in Polymer Science, Vol. 81 https://doi.org/10.1016/j.progpolymsci.2018.01.002	journal	June 2018
Method of Comparing Solid-State Kinetic Data and Its Application to the Decomposition of Kaolinite, Brucite, and BaCO3 Hancock, J. D.; Sharp, J. H. Journal of the American Ceramic Society, Vol. 55, Issue 2 https://doi.org/10.1111/j.1151-2916.1972.tb11213.x	journal	February 1972
From Heterogeneous to Homogeneous Nucleation of Isotactic Poly(propylene) Confined to Nanoporous Alumina Duran, Hatice; Steinhart, Martin; Butt, Hans-Jürgen Nano Letters, Vol. 11, Issue 4 https://doi.org/10.1021/nl200153c	journal	April 2011
Imaging Unstained Synthetic Polymer Crystals and Defects on Atomic Length Scales Using Cryogenic Electron Microscopy Jiang, Xi; Greer, Douglas R.; Kundu, Joyjit Macromolecules, Vol. 51, Issue 19 https://doi.org/10.1021/acs.macromol.8b01508	journal	September 2018
Permission to Enter Cell by Shape: Nanodisk vs Nanosphere Zhang, Yi; Tekobo, Samuel; Tu, Ying ACS Applied Materials & Interfaces, Vol. 4, Issue 8 https://doi.org/10.1021/am300840p	journal	July 2012
Tuning the Size of Cylindrical Micelles from Poly( l -lactide)- b -poly(acrylic acid) Diblock Copolymers Based on Crystallization-Driven Self-Assembly Sun, Liang; Petzetakis, Nikos; Pitto-Barry, Anaïs Macromolecules, Vol. 46, Issue 22 https://doi.org/10.1021/ma401634s	journal	November 2013
Crystallization-Driven Two-Dimensional Nanosheet from Hierarchical Self-Assembly of Polypeptoid-Based Diblock Copolymers Shi, Zhekun; Wei, Yuhan; Zhu, Chenhui Macromolecules, Vol. 51, Issue 16 https://doi.org/10.1021/acs.macromol.8b00986	journal	August 2018
A Stepwise “Micellization–Crystallization” Route to Oblate Ellipsoidal, Cylindrical, and Bilayer Micelles with Polyethylene Cores in Water Yin, Ligeng; Lodge, Timothy P.; Hillmyer, Marc A. Macromolecules, Vol. 45, Issue 23 https://doi.org/10.1021/ma302069s	journal	November 2012
Synthesis and gelation of copolypept(o)ides with random and block structure: XIAO et al. Xiao, Yan; Wang, Jianqiang; Zhang, Jun Biopolymers, Vol. 107, Issue 10 https://doi.org/10.1002/bip.23038	journal	August 2017
Liquid-Crystalline Phase Behavior in Polypeptoid Diblock Copolymers Greer, Douglas R.; Stolberg, Michael A.; Xuan, Sunting Macromolecules, Vol. 51, Issue 23 https://doi.org/10.1021/acs.macromol.8b01952	journal	November 2018
Biomineralization and osteogenic differentiation modulated by substrate stiffness Jin, Ruitao; Wang, Yuting; Liu, Yanpeng European Polymer Journal, Vol. 122 https://doi.org/10.1016/j.eurpolymj.2019.109395	journal	January 2020
Crystallization-Driven Self-Assembly of Block Copolymers with a Short Crystallizable Core-Forming Segment: Controlling Micelle Morphology through the Influence of Molar Mass and Solvent Selectivity Hsiao, Ming-Siao; Yusoff, Siti Fairus M.; Winnik, Mitchell A. Macromolecules, Vol. 47, Issue 7 https://doi.org/10.1021/ma402429d	journal	March 2014
In Situ Synchrotron X-ray Scattering Study on Isotactic Polypropylene Crystallization under the Coexistence of Shear Flow and Carbon Nanotubes Chen, Yan-Hui; Zhong, Gan-Ji; Lei, Jun Macromolecules, Vol. 44, Issue 20 https://doi.org/10.1021/ma201688p	journal	October 2011
Cylindrical Micelles of Controlled Length with a π-Conjugated Polythiophene Core via Crystallization-Driven Self-Assembly Patra, Sanjib K.; Ahmed, Rumman; Whittell, George R. Journal of the American Chemical Society, Vol. 133, Issue 23 https://doi.org/10.1021/ja202408w	journal	June 2011
Diffraction by DNA, carbon nanotubes and other helical nanostructures Lucas, Amand A.; Lambin, Philippe Reports on Progress in Physics, Vol. 68, Issue 5 https://doi.org/10.1088/0034-4885/68/5/R05	journal	April 2005
Monodisperse Cylindrical Micelles of Controlled Length with a Liquid-Crystalline Perfluorinated Core by 1D “Self-Seeding” Li, Xiaoyu; Jin, Bixin; Gao, Yang Angewandte Chemie International Edition, Vol. 55, Issue 38 https://doi.org/10.1002/anie.201604551	journal	August 2016
Rod-coil copolymers: their aggregation behavior Halperin, A. Macromolecules, Vol. 23, Issue 10 https://doi.org/10.1021/ma00212a023	journal	May 1990
Influence of Solvent Quality on the Self-Organization of Archetypical Hairy Rods−Branched and Linear Side Chain Polyfluorenes: Rodlike Chains versus “Beta-Sheets” in Solution Knaapila, M.; Garamus, V. M.; Dias, F. B. Macromolecules, Vol. 39, Issue 19 https://doi.org/10.1021/ma060886c	journal	September 2006
Hierarchical supramolecular assembly of a single peptoid polymer into a planar nanobrush with two distinct molecular packing motifs Sun, Jing; Wang, Zhiwei; Zhu, Chenhui Proceedings of the National Academy of Sciences, Vol. 117, Issue 50 https://doi.org/10.1073/pnas.2011816117	journal	December 2020
Self-Organization of Rod−Coil Molecules with Layered Crystalline States into Thermotropic Liquid Crystalline Assemblies Lee, Myongsoo; Cho, Byoung-Ki; Kim, Heesub Journal of the American Chemical Society, Vol. 120, Issue 36 https://doi.org/10.1021/ja980654w	journal	August 1998
Growth and Termination of Cylindrical Micelles via Liquid-Crystallization-Driven Self-Assembly Gao, Liang; Gao, Hongbing; Lin, Jiaping Macromolecules, Vol. 53, Issue 20 https://doi.org/10.1021/acs.macromol.0c01820	journal	October 2020
Getting into Shape: Reflections on a New Generation of Cylindrical Nanostructures’ Self-Assembly Using Polymer Building Blocks Foster, Jeffrey C.; Varlas, Spyridon; Couturaud, Benoit Journal of the American Chemical Society, Vol. 141, Issue 7 https://doi.org/10.1021/jacs.8b08648	journal	January 2019
Cylindrical Block Copolymer Micelles and Co-Micelles of Controlled Length and Architecture Wang, X.; Guerin, G.; Wang, H. Science, Vol. 317, Issue 5838, p. 644-647 https://doi.org/10.1126/science.1141382	journal	August 2007
Self-Assembled Smectic Phases in Rod-Coil Block Copolymers Chen, J. T.; Thomas, E. L.; Ober, C. K. Science, Vol. 273, Issue 5273 https://doi.org/10.1126/science.273.5273.343	journal	July 1996
Uniform Biodegradable Fiber-Like Micelles and Block Comicelles via “Living” Crystallization-Driven Self-Assembly of Poly( l -lactide) Block Copolymers: The Importance of Reducing Unimer Self-Nucleation via Hydrogen Bond Disruption He, Yunxiang; Eloi, Jean-Charles; Harniman, Robert L. Journal of the American Chemical Society, Vol. 141, Issue 48 https://doi.org/10.1021/jacs.9b09885	journal	October 2019
Polypeptoids: A perfect match for molecular definition and macromolecular engineering? Luxenhofer, Robert; Fetsch, Corinna; Grossmann, Arlett Journal of Polymer Science Part A: Polymer Chemistry, Vol. 51, Issue 13 https://doi.org/10.1002/pola.26687	journal	April 2013
Crystallization-Driven Self-Assembly of Coil–Comb-Shaped Polypeptoid Block Copolymers: Solution Morphology and Self-Assembly Pathways Jiang, Naisheng; Yu, Tianyi; Darvish, Omead A. Macromolecules, Vol. 52, Issue 22 https://doi.org/10.1021/acs.macromol.9b01546	journal	November 2019
Monodisperse cylindrical micelles by crystallization-driven living self-assembly Gilroy, Joe B.; Gädt, Torben; Whittell, George R. Nature Chemistry, Vol. 2, Issue 7 https://doi.org/10.1038/nchem.664	journal	May 2010
Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design Xuan, Sunting; Lee, Chang-Uk; Chen, Cong Chemistry of Materials, Vol. 28, Issue 3 https://doi.org/10.1021/acs.chemmater.5b03528	journal	January 2016
Smectic Ordering in Block-Copolymer Melts Semenov, A. N. Molecular Crystals and Liquid Crystals, Vol. 209, Issue 1 https://doi.org/10.1080/00268949108036194	journal	December 1991
1D vs. 2D shape selectivity in the crystallization-driven self-assembly of polylactide block copolymers Inam, Maria; Cambridge, Graeme; Pitto-Barry, Anaïs Chemical Science, Vol. 8, Issue 6 https://doi.org/10.1039/C7SC00641A	journal	January 2017
Self-Assembly of Organometallic Block Copolymers: The Role of Crystallinity of the Core-Forming Polyferrocene Block in the Micellar Morphologies Formed by Poly(ferrocenylsilane- b -dimethylsiloxane) in n -Alkane Solvents Massey, Jason A.; Temple, Karen; Cao, Lan Journal of the American Chemical Society, Vol. 122, Issue 47 https://doi.org/10.1021/ja002205d	journal	November 2000
Lipid Rafts As a Membrane-Organizing Principle Lingwood, D.; Simons, K. Science, Vol. 327, Issue 5961 https://doi.org/10.1126/science.1174621	journal	December 2009
Uniform, High Aspect Ratio Fiber-like Micelles and Block Co-micelles with a Crystalline π-Conjugated Polythiophene Core by Self-Seeding Qian, Jieshu; Li, Xiaoyu; Lunn, David J. Journal of the American Chemical Society, Vol. 136, Issue 11 https://doi.org/10.1021/ja500661k	journal	March 2014
Synthesis and Characterization of Amphiphilic Cyclic Diblock Copolypeptoids from N -Heterocyclic Carbene-Mediated Zwitterionic Polymerization of N -Substituted N -Carboxyanhydride Lee, Chang-Uk; Smart, Thomas P.; Guo, Li Macromolecules, Vol. 44, Issue 24 https://doi.org/10.1021/ma2020936	journal	December 2011
Polypeptoid Materials: Current Status and Future Perspectives Zhang, Donghui; Lahasky, Samuel H.; Guo, Li Macromolecules, Vol. 45, Issue 15 https://doi.org/10.1021/ma202319g	journal	May 2012
One-pot universal initiation-growth methods from a liquid crystalline block copolymer Jin, Bixin; Sano, Koki; Aya, Satoshi Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-10341-7	journal	June 2019
Understanding the CDSA of poly(lactide) containing triblock copolymers Yu, Wei; Inam, Maria; Jones, Joseph R. Polymer Chemistry, Vol. 8, Issue 36 https://doi.org/10.1039/C7PY01056G	journal	January 2017
Crystallization-Driven Thermoreversible Gelation of Coil-Crystalline Cyclic and Linear Diblock Copolypeptoids Lee, Chang-Uk; Lu, Lu; Chen, Jihua ACS Macro Letters, Vol. 2, Issue 5 https://doi.org/10.1021/mz300667n	journal	April 2013
Development of Structural Complexity by Liquid-Crystal Self-assembly Tschierske, Carsten Angewandte Chemie International Edition, Vol. 52, Issue 34 https://doi.org/10.1002/anie.201300872	journal	August 2013
Scattering Form Factor of Block Copolymer Micelles Pedersen, Jan Skov; Gerstenberg, Michael C. Macromolecules, Vol. 29, Issue 4 https://doi.org/10.1021/ma9512115	journal	January 1996
Toward Uniform Nanofibers with a π-Conjugated Core: Optimizing the “Living” Crystallization-Driven Self-Assembly of Diblock Copolymers with a Poly(3-octylthiophene) Core-Forming Block Tritschler, Ulrich; Gwyther, Jessica; Harniman, Robert L. Macromolecules, Vol. 51, Issue 14 https://doi.org/10.1021/acs.macromol.8b00488	journal	July 2018
Polymers for gene delivery across length scales Putnam, David Nature Materials, Vol. 5, Issue 6 https://doi.org/10.1038/nmat1645	journal	June 2006
Synthesis and Characterization of Well-Defined PEGylated Polypeptoids as Protein-Resistant Polymers Xuan, Sunting; Gupta, Sudipta; Li, Xin Biomacromolecules, Vol. 18, Issue 3 https://doi.org/10.1021/acs.biomac.6b01824	journal	February 2017
Kinetics of Phase Change. II Transformation‐Time Relations for Random Distribution of Nuclei Avrami, Melvin The Journal of Chemical Physics, Vol. 8, Issue 2 https://doi.org/10.1063/1.1750631	journal	February 1940
Two-dimensional assemblies from crystallizable homopolymers with charged termini He, Xiaoming; Hsiao, Ming-Siao; Boott, Charlotte E. Nature Materials, Vol. 16, Issue 4 https://doi.org/10.1038/nmat4837	journal	January 2017
Nanoscale Phase Separation in Sequence-Defined Peptoid Diblock Copolymers Sun, Jing; Teran, Alexander A.; Liao, Xunxun Journal of the American Chemical Society, Vol. 135, Issue 38 https://doi.org/10.1021/ja404233d	journal	September 2013
Solution crystallization of polyethylene at high temperatures: Part 1 Lateral crystal habits Organ, S. J.; Keller, A. Journal of Materials Science, Vol. 20, Issue 5 https://doi.org/10.1007/BF00555261	journal	May 1985
50th Anniversary Perspective : Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers Tritschler, Ulrich; Pearce, Sam; Gwyther, Jessica Macromolecules, Vol. 50, Issue 9 https://doi.org/10.1021/acs.macromol.6b02767	journal	April 2017
Precision Epitaxy for Aqueous 1D and 2D Poly(ε-caprolactone) Assemblies Arno, Maria C.; Inam, Maria; Coe, Zachary Journal of the American Chemical Society, Vol. 139, Issue 46 https://doi.org/10.1021/jacs.7b10199	journal	November 2017
Shape effects of filaments versus spherical particles in flow and drug delivery Geng, Yan; Dalhaimer, Paul; Cai, Shenshen Nature Nanotechnology, Vol. 2, Issue 4 https://doi.org/10.1038/nnano.2007.70	journal	March 2007
Tailored hierarchical micelle architectures using living crystallization-driven self-assembly in two dimensions Hudson, Zachary M.; Boott, Charlotte E.; Robinson, Matthew E. Nature Chemistry, Vol. 6, Issue 10 https://doi.org/10.1038/nchem.2038	journal	September 2014
Cyclic Topology Enhancing Structural Ordering and Stability of Comb-Shaped Polypeptoid Thin Films against Melt-Induced Dewetting Jiang, Naisheng; Chen, Jianxia; Yu, Tianyi Macromolecules, Vol. 53, Issue 17 https://doi.org/10.1021/acs.macromol.0c01205	journal	August 2020
Synthesis, Characterization, and Photovoltaic Properties of a Low Band Gap Polymer Based on Silole-Containing Polythiophenes and 2,1,3-Benzothiadiazole Hou, Jianhui; Chen, Hsiang-Yu; Zhang, Shaoqing Journal of the American Chemical Society, Vol. 130, Issue 48, p. 16144-16145 https://doi.org/10.1021/ja806687u	journal	December 2008
General Pathway toward Crystalline-Core Micelles with Tunable Morphology and Corona Segregation Schmelz, Joachim; Karg, Matthias; Hellweg, Thomas ACS Nano, Vol. 5, Issue 12 https://doi.org/10.1021/nn202638t	journal	November 2011
Peptoids and Polypeptoids at the Frontier of Supra- and Macromolecular Engineering Gangloff, Niklas; Ulbricht, Juliane; Lorson, Thomas Chemical Reviews, Vol. 116, Issue 4 https://doi.org/10.1021/acs.chemrev.5b00201	journal	December 2015

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