Title: Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Abstract

Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen ( ¹ O ₂ ) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. In this paper, a simple and effective multimodal therapeutic system was designed via combining chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain. IR-780 (IR780) dye-labeled tube-forming peptoids (PepIR) were synthesized and self-assembled into crystalline nanotubes (PepIR nanotubes). These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density; thus, a self-quenching of these IR780 molecules was significantly reduced. Moreover, the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells. Given the unique properties of peptoids and peptoid nanotubes, we believe that the developedmore » multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.« less

Authors:

Cai, Xiaoli ^[1]; Wang, Mingming ^[2]; Mu, Peng ^[3]; Jian, Tengyue ^[2]; Liu, Dong ^[1]; Ding, Shichao  ^[1];

• Search DOE PAGES for author "Ding, Shichao"
• Search DOE PAGES for ORCID "0000-0003-3795-306X"

Luo, Yanan ^[1]; Du, Dan  ^[1];

• Search DOE PAGES for author "Du, Dan"
• Search DOE PAGES for ORCID "0000-0003-1952-4042"

Song, Yang  ^[1];

• Search DOE PAGES for author "Song, Yang"
• Search DOE PAGES for ORCID "0000-0003-0848-4831"

Chen, Chun-Long  ^[2];

• Search DOE PAGES for author "Chen, Chun-Long"
• Search DOE PAGES for ORCID "0000-0002-5584-824X"

Lin, Yuehe  ^[1]

• Search DOE PAGES for author "Lin, Yuehe"
• Search DOE PAGES for ORCID "0000-0003-3791-7587"

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+ Show Author Affiliations

1. School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
2. Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
3. Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA, Department of Mechanical Engineering and Materials Science and Engineering Program, State University of New York, Binghamton, New York 13902, USA

Publication Date:

Sun May 16 00:00:00 EDT 2021

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:

1783304

Alternate Identifier(s):

OSTI ID: 1811675

Report Number(s):

PNNL-SA-160831
Journal ID: ISSN 2639-5274; 2021/9861384

Grant/Contract Number:  

AC02-05CH11231; AC05-76RL01830

Resource Type:

Published Article

Journal Name:

Research

Additional Journal Information:

Journal Name: Research Journal Volume: 2021; Journal ID: ISSN 2639-5274

Publisher:

American Association for the Advancement of Science (AAAS)

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES; Peptoid; Nanotube; Chemo-Phototherapy