Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies
Abstract
Peptoids are a family of sequence-defined, non-natural biomimetic polymers which show excellent properties including good chemical and enzymatic stability and high structural tunability. The solid-phase submonomer synthesis method allows precise control over the identity and sequence of chemically diverse side chains, enabling the atomic engineering of their chemical structures for a variety of applications. This unprecedented level of structural control enables access to atomically defined three-dimensional chain conformations and assemblies, facilitating the design and optimization of a variety of nanoscale architectures that can function in biology and materials science. In order to approach the rational design of peptoid materials in a more predictive and precise manner, it is crucial to fully understand how chemical information, in the form of the monomer sequence, encodes their folding and assembly into structurally defined, functional 3D shapes. Furthermore, this perspective focuses on recent studies into the atomic engineering of peptoid nanostructures by examining the impact of sequence variations on their secondary and three-dimensional structures, as well as their functional properties.
- Authors:
-
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1782161
- Alternate Identifier(s):
- OSTI ID: 1633397
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Polymer
- Additional Journal Information:
- Journal Volume: 202; Journal ID: ISSN 0032-3861
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Sequence-defined polymers; Peptoids; Diblock copolymers; Biomimetic polymers; Self-assembly; Sequence-controlled polymers
Citation Formats
Xuan, Sunting, and Zuckermann, Ronald N. Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies. United States: N. p., 2020.
Web. doi:10.1016/j.polymer.2020.122691.
Xuan, Sunting, & Zuckermann, Ronald N. Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies. United States. https://doi.org/10.1016/j.polymer.2020.122691
Xuan, Sunting, and Zuckermann, Ronald N. Sat .
"Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies". United States. https://doi.org/10.1016/j.polymer.2020.122691. https://www.osti.gov/servlets/purl/1782161.
@article{osti_1782161,
title = {Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies},
author = {Xuan, Sunting and Zuckermann, Ronald N.},
abstractNote = {Peptoids are a family of sequence-defined, non-natural biomimetic polymers which show excellent properties including good chemical and enzymatic stability and high structural tunability. The solid-phase submonomer synthesis method allows precise control over the identity and sequence of chemically diverse side chains, enabling the atomic engineering of their chemical structures for a variety of applications. This unprecedented level of structural control enables access to atomically defined three-dimensional chain conformations and assemblies, facilitating the design and optimization of a variety of nanoscale architectures that can function in biology and materials science. In order to approach the rational design of peptoid materials in a more predictive and precise manner, it is crucial to fully understand how chemical information, in the form of the monomer sequence, encodes their folding and assembly into structurally defined, functional 3D shapes. Furthermore, this perspective focuses on recent studies into the atomic engineering of peptoid nanostructures by examining the impact of sequence variations on their secondary and three-dimensional structures, as well as their functional properties.},
doi = {10.1016/j.polymer.2020.122691},
journal = {Polymer},
number = ,
volume = 202,
place = {United States},
year = {Sat Jun 06 00:00:00 EDT 2020},
month = {Sat Jun 06 00:00:00 EDT 2020}
}
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