Strategies for Constructing and Operating DNA Origami Linear Actuators

Benson, Erik; Carrascosa Marzo, Rafael; Bath, Jonathan; Turberfield, Andrew J.

doi:10.1002/smll.202007704

Title: Strategies for Constructing and Operating DNA Origami Linear Actuators

Abstract

Abstract Linear actuators are ubiquitous components at all scales of engineering. DNA nanotechnology offers a unique opportunity for bottom‐up assembly at the molecular scale, providing nanoscale precision with multiple methods for constructing and operating devices. In this paper, DNA origami linear actuators with up to 200 nm travel, based on a rail threading a topologically locked slider, are demonstrated. Two strategies, one‐ and two‐pot assembly, are demonstrated whereby the two components are folded from one or two DNA scaffold strands, respectively. In order to control the position of the slider on the rail, the rail and the inside of the slider are decorated with single‐stranded oligonucleotides with distinct sequences. Two positioning strategies, based on diffusion and capture of signaling strands, are used to link the slider reversibly to determined positions on the rail with high yield and precision. These machine components provide a basis for applications in molecular machinery and nanoscale manufacture including programmed chemical synthesis.

Authors:

Benson, Erik ^[1];

^[1];

^[1]

Department of Physics University of Oxford Parks Road Oxford OX1 3PU UK

Publication Date:: Tue May 04 00:00:00 EDT 2021

Research Org.:: Univ. of Oxford (United Kingdom)

Sponsoring Org.:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Energy Efficiency Office. Advanced Manufacturing Office; European Research Council (ERC)

OSTI Identifier:: 1781435

Alternate Identifier(s):: OSTI ID: 1781438; OSTI ID: 1782725

Grant/Contract Number:: EE0008310; 842291; 765703

Resource Type:: Published Article

Journal Name:: Small

Additional Journal Information:: Journal Name: Small Journal Volume: 17 Journal Issue: 20; Journal ID: ISSN 1613-6810

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: Germany

Language:: English

Subject:: 77 NANOSCIENCE AND NANOTECHNOLOGY; DNA origami; DNA nanotechnology; linear actuators; DNA mechanisms; self‐assembly

Citation Formats


                    Benson, Erik, Carrascosa Marzo, Rafael, Bath, Jonathan, and Turberfield, Andrew J. Strategies for Constructing and Operating DNA Origami Linear Actuators.  Germany: N. p., 2021. 
Web.  doi:10.1002/smll.202007704.

Copy to clipboard


                    Benson, Erik, Carrascosa Marzo, Rafael, Bath, Jonathan, & Turberfield, Andrew J. Strategies for Constructing and Operating DNA Origami Linear Actuators.  Germany.  https://doi.org/10.1002/smll.202007704

Copy to clipboard


                    Benson, Erik, Carrascosa Marzo, Rafael, Bath, Jonathan, and Turberfield, Andrew J. Tue .  
"Strategies for Constructing and Operating DNA Origami Linear Actuators".  Germany.  https://doi.org/10.1002/smll.202007704.

Copy to clipboard


                    
@article{osti_1781435,

  title        = {Strategies for Constructing and Operating DNA Origami Linear Actuators},

  author       = {Benson, Erik and Carrascosa Marzo, Rafael and Bath, Jonathan and Turberfield, Andrew J.},

  abstractNote = {Abstract Linear actuators are ubiquitous components at all scales of engineering. DNA nanotechnology offers a unique opportunity for bottom‐up assembly at the molecular scale, providing nanoscale precision with multiple methods for constructing and operating devices. In this paper, DNA origami linear actuators with up to 200 nm travel, based on a rail threading a topologically locked slider, are demonstrated. Two strategies, one‐ and two‐pot assembly, are demonstrated whereby the two components are folded from one or two DNA scaffold strands, respectively. In order to control the position of the slider on the rail, the rail and the inside of the slider are decorated with single‐stranded oligonucleotides with distinct sequences. Two positioning strategies, based on diffusion and capture of signaling strands, are used to link the slider reversibly to determined positions on the rail with high yield and precision. These machine components provide a basis for applications in molecular machinery and nanoscale manufacture including programmed chemical synthesis.},

  doi          = {10.1002/smll.202007704},

  journal      = {Small},

  number       = 20,

  volume       = 17,

  place        = {Germany},

  year         = {Tue May 04 00:00:00 EDT 2021},

  month        = {Tue May 04 00:00:00 EDT 2021}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
https://doi.org/10.1002/smll.202007704

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Super-resolution microscopy with DNA-PAINT
journal, May 2017

Schnitzbauer, Joerg; Strauss, Maximilian T.; Schlichthaerle, Thomas
Nature Protocols, Vol. 12, Issue 6
DOI: 10.1038/nprot.2017.024

Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure
journal, November 2017

Centola, Mathias; Valero, Julián; Famulok, Michael
Journal of the American Chemical Society, Vol. 139, Issue 45
DOI: 10.1021/jacs.7b08839

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
journal, October 2012

Derr, N. D.; Goodman, B. S.; Jungmann, R.
Science, Vol. 338, Issue 6107
DOI: 10.1126/science.1226734

A self-assembled nanoscale robotic arm controlled by electric fields
journal, January 2018

Kopperger, Enzo; List, Jonathan; Madhira, Sushi
Science, Vol. 359, Issue 6373
DOI: 10.1126/science.aao4284

An easy-to-prepare mini-scaffold for DNA origami
journal, January 2015

Brown, S.; Majikes, J.; Martínez, A.
Nanoscale, Vol. 7, Issue 40
DOI: 10.1039/C5NR04921K

Rapid prototyping of 3D DNA-origami shapes with caDNAno
journal, June 2009

Douglas, Shawn M.; Marblestone, Adam H.; Teerapittayanon, Surat
Nucleic Acids Research, Vol. 37, Issue 15
DOI: 10.1093/nar/gkp436

Reconfigurable, braced, three-dimensional DNA nanostructures
journal, February 2008

Goodman, Russell P.; Heilemann, Mike; Doose, Sören
Nature Nanotechnology, Vol. 3, Issue 2
DOI: 10.1038/nnano.2008.3

TacoxDNA: A user‐friendly web server for simulations of complex DNA structures, from single strands to origami
journal, July 2019

Suma, Antonio; Poppleton, Erik; Matthies, Michael
Journal of Computational Chemistry, Vol. 40, Issue 29
DOI: 10.1002/jcc.26029

Reversible Light Switch for Macrocycle Mobility in a DNA Rotaxane
journal, July 2012

Lohmann, Finn; Ackermann, Damian; Famulok, Michael
Journal of the American Chemical Society, Vol. 134, Issue 29
DOI: 10.1021/ja3042096

Coarse-grained modelling of the structural properties of DNA origami
journal, January 2019

Snodin, Benedict E. K.; Schreck, John S.; Romano, Flavio
Nucleic Acids Research, Vol. 47, Issue 3
DOI: 10.1093/nar/gky1304

DNA Origami as a Carrier for Circumvention of Drug Resistance
journal, August 2012

Jiang, Qiao; Song, Chen; Nangreave, Jeanette
Journal of the American Chemical Society, Vol. 134, Issue 32
DOI: 10.1021/ja304263n

DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs
journal, March 2010

Gu, Hongzhou; Yang, Wei; Seeman, Nadrian C.
Journal of the American Chemical Society, Vol. 132, Issue 12
DOI: 10.1021/ja910188p

Uncovering the forces between nucleosomes using DNA origami
journal, November 2016

Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna
Science Advances, Vol. 2, Issue 11
DOI: 10.1126/sciadv.1600974

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
journal, April 2019

Engelhardt, Floris A. S.; Praetorius, Florian; Wachauf, Christian H.
ACS Nano, Vol. 13, Issue 5
DOI: 10.1021/acsnano.9b01025

Self-assembly of a nanoscale DNA box with a controllable lid
journal, May 2009

Andersen, Ebbe S.; Dong, Mingdong; Nielsen, Morten M.
Nature, Vol. 459, Issue 7243
DOI: 10.1038/nature07971

Folding DNA to create nanoscale shapes and patterns
journal, March 2006

Rothemund, Paul W. K.
Nature, Vol. 440, Issue 7082, p. 297-302
DOI: 10.1038/nature04586

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT
journal, February 2014

Jungmann, Ralf; Avendaño, Maier S.; Woehrstein, Johannes B.
Nature Methods, Vol. 11, Issue 3
DOI: 10.1038/nmeth.2835

Programmable motion of DNA origami mechanisms
journal, January 2015

Marras, Alexander E.; Zhou, Lifeng; Su, Hai-Jun
Proceedings of the National Academy of Sciences, Vol. 112, Issue 3
DOI: 10.1073/pnas.1408869112

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
journal, February 2012

Douglas, S. M.; Bachelet, I.; Church, G. M.
Science, Vol. 335, Issue 6070
DOI: 10.1126/science.1214081

Molecular force spectroscopy with a DNA origami–based nanoscopic force clamp
journal, October 2016

Nickels, Philipp C.; Wünsch, Bettina; Holzmeister, Phil
Science, Vol. 354, Issue 6310
DOI: 10.1126/science.aah5974

A Synthetic DNA Walker for Molecular Transport
journal, September 2004

Shin, Jong-Shik; Pierce, Niles A.
Journal of the American Chemical Society, Vol. 126, Issue 35
DOI: 10.1021/ja047543j

Nanoscale rotary apparatus formed from tight-fitting 3D DNA components
journal, February 2016

Ketterer, Philip; Willner, Elena M.; Dietz, Hendrik
Science Advances, Vol. 2, Issue 2
DOI: 10.1126/sciadv.1501209

Control of enzyme reactions by a reconfigurable DNA nanovault
journal, October 2017

Grossi, Guido; Dalgaard Ebbesen Jepsen, Mette; Kjems, Jørgen
Nature Communications, Vol. 8, Issue 1
DOI: 10.1038/s41467-017-01072-8

Shape-Controlled Synthesis of Gold Nanostructures Using DNA Origami Molds
journal, October 2014

Helmi, Seham; Ziegler, Christoph; Kauert, Dominik J.
Nano Letters, Vol. 14, Issue 11
DOI: 10.1021/nl503441v

Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
journal, November 2009

Maune, Hareem T.; Han, Si-ping; Barish, Robert D.
Nature Nanotechnology, Vol. 5, Issue 1
DOI: 10.1038/nnano.2009.311

From The Cover: Triggered amplification by hybridization chain reaction
journal, October 2004

Dirks, R. M.; Pierce, N. A.
Proceedings of the National Academy of Sciences, Vol. 101, Issue 43
DOI: 10.1073/pnas.0407024101

An autonomous molecular assembler for programmable chemical synthesis
journal, April 2016

Meng, Wenjing; Muscat, Richard A.; McKee, Mireya L.
Nature Chemistry, Vol. 8, Issue 6
DOI: 10.1038/nchem.2495

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades
journal, June 2011

Qian, L.; Winfree, E.
Science, Vol. 332, Issue 6034
DOI: 10.1126/science.1200520

Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation
journal, May 2020

Poppleton, Erik; Bohlin, Joakim; Matthies, Michael
Nucleic Acids Research, Vol. 48, Issue 12
DOI: 10.1093/nar/gkaa417

DNA Origami Post‐Processing by CRISPR‐Cas12a
journal, January 2020

Xiong, Qiancheng; Xie, Chun; Zhang, Zhao
Angewandte Chemie International Edition, Vol. 59, Issue 10
DOI: 10.1002/anie.201915555

DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching
journal, August 2016

Powell, John T.; Akhuetie-Oni, Benjamin O.; Zhang, Zhao
Angewandte Chemie International Edition, Vol. 55, Issue 38
DOI: 10.1002/anie.201604621

Coordinated Chemomechanical Cycles: A Mechanism for Autonomous Molecular Motion
journal, December 2008

Green, S. J.; Bath, J.; Turberfield, A. J.
Physical Review Letters, Vol. 101, Issue 23
DOI: 10.1103/PhysRevLett.101.238101

Direct Mechanical Measurements Reveal the Material Properties of Three-Dimensional DNA Origami
journal, December 2011

Kauert, Dominik J.; Kurth, Thomas; Liedl, Tim
Nano Letters, Vol. 11, Issue 12
DOI: 10.1021/nl203503s

A double-stranded DNA rotaxane
journal, April 2010

Ackermann, Damian; Schmidt, Thorsten L.; Hannam, Jeffrey S.
Nature Nanotechnology, Vol. 5, Issue 6
DOI: 10.1038/nnano.2010.65

Long-range movement of large mechanically interlocked DNA nanostructures
journal, August 2016

List, Jonathan; Falgenhauer, Elisabeth; Kopperger, Enzo
Nature Communications, Vol. 7, Issue 1
DOI: 10.1038/ncomms12414

Mechanical design of DNA nanostructures
journal, January 2015

Castro, Carlos E.; Su, Hai-Jun; Marras, Alexander E.
Nanoscale, Vol. 7, Issue 14
DOI: 10.1039/C4NR07153K

A Precisely Controlled DNA Biped Walking Device
journal, July 2004

Sherman, William B.; Seeman, Nadrian C.
Nano Letters, Vol. 4, Issue 7
DOI: 10.1021/nl049527q

Purification of Functionalized DNA Origami Nanostructures
journal, May 2015

Shaw, Alan; Benson, Erik; Högberg, Björn
ACS Nano, Vol. 9, Issue 5
DOI: 10.1021/nn507035g

Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers
journal, April 2018

Lauback, Stephanie; Mattioli, Kara R.; Marras, Alexander E.
Nature Communications, Vol. 9, Issue 1
DOI: 10.1038/s41467-018-03601-5

Self-assembly of three-dimensional prestressed tensegrity structures from DNA
journal, June 2010

Liedl, Tim; Högberg, Björn; Tytell, Jessica
Nature Nanotechnology, Vol. 5, Issue 7
DOI: 10.1038/nnano.2010.107

Casting inorganic structures with DNA molds
journal, October 2014

Sun, W.; Boulais, E.; Hakobyan, Y.
Science, Vol. 346, Issue 6210
DOI: 10.1126/science.1258361

DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
journal, March 2012

Kuzyk, Anton; Schreiber, Robert; Fan, Zhiyuan
Nature, Vol. 483, Issue 7389
DOI: 10.1038/nature10889

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties
journal, September 2012

Zhao, Yong-Xing; Shaw, Alan; Zeng, Xianghui
ACS Nano, Vol. 6, Issue 10
DOI: 10.1021/nn3022662

Nucleic acid junctions and lattices
journal, November 1982

Seeman, Nadrian C.
Journal of Theoretical Biology, Vol. 99, Issue 2
DOI: 10.1016/0022-5193(82)90002-9

Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker
journal, October 2010

He, Yu; Liu, David R.
Nature Nanotechnology, Vol. 5, Issue 11
DOI: 10.1038/nnano.2010.190

Interlocked DNA nanostructures controlled by a reversible logic circuit
journal, September 2014

Li, Tao; Lohmann, Finn; Famulok, Michael
Nature Communications, Vol. 5, Issue 1
DOI: 10.1038/ncomms5940

A proximity-based programmable DNA nanoscale assembly line
journal, May 2010

Gu, Hongzhou; Chao, Jie; Xiao, Shou-Jun
Nature, Vol. 465, Issue 7295
DOI: 10.1038/nature09026

DNA nanotechnology
journal, November 2017

Seeman, Nadrian C.; Sleiman, Hanadi F.
Nature Reviews Materials, Vol. 3, Issue 1
DOI: 10.1038/natrevmats.2017.68

Self-assembly of DNA into nanoscale three-dimensional shapes
journal, May 2009

Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim
Nature, Vol. 459, Issue 7245
DOI: 10.1038/nature08016

Similar Records in DOE PAGES and OSTI.GOV collections:

A DNA molecular printer capable of programmable positioning and patterning in two dimensions

Journal Article Benson, Erik ; Marzo, Rafael Carrascosa ; Bath, Jonathan ; ... - Science Robotics

Nanoscale manipulation and patterning usually require costly and sensitive top-down techniques such as those used in scanning probe microscopies or in semiconductor lithography. DNA nanotechnology enables exploration of bottom-up fabrication and has previously been used to design self-assembling components capable of linear and rotary motion. In this work, we combine three independently controllable DNA origami linear actuators to create a nanoscale robotic printer. The two-axis positioning mechanism comprises a moveable gantry, running on parallel rails, threading a mobile sleeve. We show that the device is capable of reversibly positioning a write head over a canvas through the addition of signalingmore »« less
https://doi.org/10.1126/scirobotics.abn5459

Full Text Available
Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures

Journal Article Yang, Yunqi ; Lu, Qinyi ; Chen, Yu ; ... - Angewandte Chemie (International Edition)

Abstract DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucleases. Recently, we showed how enzymatic polymerization could be harnessed to grow polynucleotide brushes of tunable length and location on the surface of DNA origami nanostructures, which greatly enhances their nuclease stability. Here, we report on strategies that allow for both spatial and temporal control over polymerization through activatable initiation, cleavage, and regeneration of polynucleotide brushes using restriction enzymes. The ability to site‐specifically decorate DNA origamimore »« less
https://doi.org/10.1002/anie.202311727
Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures

Journal Article Yang, Yunqi ; Lu, Qinyi ; Chen, Yu ; ... - Angewandte Chemie

Abstract DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucleases. Recently, we showed how enzymatic polymerization could be harnessed to grow polynucleotide brushes of tunable length and location on the surface of DNA origami nanostructures, which greatly enhances their nuclease stability. Here, we report on strategies that allow for both spatial and temporal control over polymerization through activatable initiation, cleavage, and regeneration of polynucleotide brushes using restriction enzymes. The ability to site‐specifically decorate DNA origamimore »« less
https://doi.org/10.1002/ange.202311727
The path towards functional nanoparticle-DNA origami composites

Journal Article Johnson, Joshua A. ; Dehankar, Abhilasha ; Robbins, Ariel ; ... - Materials Science and Engineering. R, Reports

Nanoparticles (NPs) hold tremendous promise for diverse applications infields such as imaging, sensing, nanorobotics, and for optical and electronic materials. These applications often require precisely controlled interactions between multiple NPs or between NPs and other components. Hence, the organization of NPs into composite materials has been an active area of research. DNA origami nanotechnology offers a promising path forward with unparalleled control over complex nanoscale geometry and functionalization, programmed dynamic and mechanical properties, stimulus response to local or externally applied triggers, and capability of assembly into higher-order 1D, 2D, or 3D materials. Furthermore, DNA origami self-assembly is rapid and scalable,more »« less
Cited by 10
https://doi.org/10.1016/j.mser.2019.06.003

Full Text Available
Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light

Journal Article Li, Ruixin ; Chen, Haorong ; Lee, Hyeongwoon ; ... - Methods and Protocols

DNA origami has garnered great attention due to its excellent programmability and precision. It offers a powerful means to create complex nanostructures which may not be possible by other methods. The macromolecular structures may be used as static templates for arranging proteins and other molecules. They are also capable of undergoing structural transformation in response to external signals, which may be exploited for sensing and actuation at the nanoscale. Such on-demand reconfigurations are executed mostly by DNA oligomers through base-pairing and/or strand displacement, demonstrating drastic shape changes between two different states, for example, open and close. Recent studies have developedmore »« less
https://doi.org/10.3390/mps4020038

Similar Records

Title: Strategies for Constructing and Operating DNA Origami Linear Actuators

Abstract

Citation Formats

Super-resolution microscopy with DNA-PAINT journal, May 2017

Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure journal, November 2017

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold journal, October 2012

A self-assembled nanoscale robotic arm controlled by electric fields journal, January 2018

An easy-to-prepare mini-scaffold for DNA origami journal, January 2015

Rapid prototyping of 3D DNA-origami shapes with caDNAno journal, June 2009

Reconfigurable, braced, three-dimensional DNA nanostructures journal, February 2008

TacoxDNA: A user‐friendly web server for simulations of complex DNA structures, from single strands to origami journal, July 2019

Reversible Light Switch for Macrocycle Mobility in a DNA Rotaxane journal, July 2012

Coarse-grained modelling of the structural properties of DNA origami journal, January 2019

DNA Origami as a Carrier for Circumvention of Drug Resistance journal, August 2012

DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs journal, March 2010

Uncovering the forces between nucleosomes using DNA origami journal, November 2016

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds journal, April 2019

Self-assembly of a nanoscale DNA box with a controllable lid journal, May 2009

Folding DNA to create nanoscale shapes and patterns journal, March 2006

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT journal, February 2014

Programmable motion of DNA origami mechanisms journal, January 2015

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads journal, February 2012

Molecular force spectroscopy with a DNA origami–based nanoscopic force clamp journal, October 2016

A Synthetic DNA Walker for Molecular Transport journal, September 2004

Nanoscale rotary apparatus formed from tight-fitting 3D DNA components journal, February 2016

Control of enzyme reactions by a reconfigurable DNA nanovault journal, October 2017

Shape-Controlled Synthesis of Gold Nanostructures Using DNA Origami Molds journal, October 2014

Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates journal, November 2009

From The Cover: Triggered amplification by hybridization chain reaction journal, October 2004

An autonomous molecular assembler for programmable chemical synthesis journal, April 2016

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades journal, June 2011

Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation journal, May 2020

DNA Origami Post‐Processing by CRISPR‐Cas12a journal, January 2020

DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching journal, August 2016

Coordinated Chemomechanical Cycles: A Mechanism for Autonomous Molecular Motion journal, December 2008

Direct Mechanical Measurements Reveal the Material Properties of Three-Dimensional DNA Origami journal, December 2011

A double-stranded DNA rotaxane journal, April 2010

Long-range movement of large mechanically interlocked DNA nanostructures journal, August 2016

Mechanical design of DNA nanostructures journal, January 2015

A Precisely Controlled DNA Biped Walking Device journal, July 2004

Purification of Functionalized DNA Origami Nanostructures journal, May 2015

Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers journal, April 2018

Self-assembly of three-dimensional prestressed tensegrity structures from DNA journal, June 2010

Casting inorganic structures with DNA molds journal, October 2014

DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response journal, March 2012

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties journal, September 2012

Nucleic acid junctions and lattices journal, November 1982

Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker journal, October 2010

Interlocked DNA nanostructures controlled by a reversible logic circuit journal, September 2014

A proximity-based programmable DNA nanoscale assembly line journal, May 2010

DNA nanotechnology journal, November 2017

Self-assembly of DNA into nanoscale three-dimensional shapes journal, May 2009

Super-resolution microscopy with DNA-PAINT
journal, May 2017

Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure
journal, November 2017

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
journal, October 2012

A self-assembled nanoscale robotic arm controlled by electric fields
journal, January 2018

An easy-to-prepare mini-scaffold for DNA origami
journal, January 2015

Rapid prototyping of 3D DNA-origami shapes with caDNAno
journal, June 2009

Reconfigurable, braced, three-dimensional DNA nanostructures
journal, February 2008

TacoxDNA: A user‐friendly web server for simulations of complex DNA structures, from single strands to origami
journal, July 2019

Reversible Light Switch for Macrocycle Mobility in a DNA Rotaxane
journal, July 2012

Coarse-grained modelling of the structural properties of DNA origami
journal, January 2019

DNA Origami as a Carrier for Circumvention of Drug Resistance
journal, August 2012

DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs
journal, March 2010

Uncovering the forces between nucleosomes using DNA origami
journal, November 2016

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
journal, April 2019

Self-assembly of a nanoscale DNA box with a controllable lid
journal, May 2009

Folding DNA to create nanoscale shapes and patterns
journal, March 2006

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT
journal, February 2014

Programmable motion of DNA origami mechanisms
journal, January 2015

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
journal, February 2012

Molecular force spectroscopy with a DNA origami–based nanoscopic force clamp
journal, October 2016

A Synthetic DNA Walker for Molecular Transport
journal, September 2004

Nanoscale rotary apparatus formed from tight-fitting 3D DNA components
journal, February 2016

Control of enzyme reactions by a reconfigurable DNA nanovault
journal, October 2017

Shape-Controlled Synthesis of Gold Nanostructures Using DNA Origami Molds
journal, October 2014

Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
journal, November 2009

From The Cover: Triggered amplification by hybridization chain reaction
journal, October 2004

An autonomous molecular assembler for programmable chemical synthesis
journal, April 2016

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades
journal, June 2011

Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation
journal, May 2020

DNA Origami Post‐Processing by CRISPR‐Cas12a
journal, January 2020

DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching
journal, August 2016

Coordinated Chemomechanical Cycles: A Mechanism for Autonomous Molecular Motion
journal, December 2008

Direct Mechanical Measurements Reveal the Material Properties of Three-Dimensional DNA Origami
journal, December 2011

A double-stranded DNA rotaxane
journal, April 2010

Long-range movement of large mechanically interlocked DNA nanostructures
journal, August 2016

Mechanical design of DNA nanostructures
journal, January 2015

A Precisely Controlled DNA Biped Walking Device
journal, July 2004

Purification of Functionalized DNA Origami Nanostructures
journal, May 2015

Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers
journal, April 2018

Self-assembly of three-dimensional prestressed tensegrity structures from DNA
journal, June 2010

Casting inorganic structures with DNA molds
journal, October 2014

DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
journal, March 2012

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties
journal, September 2012

Nucleic acid junctions and lattices
journal, November 1982

Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker
journal, October 2010

Interlocked DNA nanostructures controlled by a reversible logic circuit
journal, September 2014

A proximity-based programmable DNA nanoscale assembly line
journal, May 2010

DNA nanotechnology
journal, November 2017

Self-assembly of DNA into nanoscale three-dimensional shapes
journal, May 2009