Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Sherekar, Mukul; Han, Sae-Won; Ghirlando, Rodolfo; Messing, Simon; Drew, Matthew; Rabara, Dana; Waybright, Timothy; Juneja, Puneet; O'Neill, Hugh; Stanley, Christopher B.; Bhowmik, Debsindhu; Ramanathan, Arvind; Subramaniam, Sriram; Nissley, Dwight V.; Gillette, William; McCormick, Frank; Esposito, Dominic

doi:10.1016/S0021-9258(17)49919-4

Title: Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Journal Article · 31 December 2019 · Journal of Biological Chemistry

DOI: https://doi.org/10.1016/S0021-9258(17)49919-4 · OSTI ID:1780386

; Han, Sae-Won;

; Messing, Simon; Drew, Matthew; Rabara, Dana; Waybright, Timothy; Juneja, Puneet; O'Neill, Hugh;

; Bhowmik, Debsindhu; Ramanathan, Arvind; Subramaniam, Sriram; Nissley, Dwight V.; Gillette, William; McCormick, Frank;

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1780386

Journal Information:: Journal of Biological Chemistry, Journal Name: Journal of Biological Chemistry Journal Issue: 4 Vol. 295; ISSN 0021-9258

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (42)

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin Welti, Stefan; Kühn, Sonja; D'Angelo, Igor Human Mutation, Vol. 32, Issue 2 https://doi.org/10.1002/humu.21405	journal	January 2011
UCSF Chimera?A visualization system for exploratory research and analysis Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C. Journal of Computational Chemistry, Vol. 25, Issue 13 https://doi.org/10.1002/jcc.20084	journal	January 2004
Optimizing Expression and Solubility of Proteins in E. coli Using Modified Media and Induction Parameters Taylor, Troy; Denson, John-Paul; Esposito, Dominic Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-6887-9_5	book	May 2017
Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules Gregory, Paula E.; Gutmann, David H.; Mitchell, Anna Somatic Cell and Molecular Genetics, Vol. 19, Issue 3 https://doi.org/10.1007/BF01233074	journal	May 1993
Mutational and functional analysis of the neurofibromatosis type 1 ( NF1 ) gene Upadhyaya, M.; Osborn, Michael J.; Maynard, Julie Human Genetics, Vol. 99, Issue 1 https://doi.org/10.1007/s004390050317	journal	December 1996
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase Izawa, Ichiro; Tamaki, Norihiko; Saya, Hideyuki FEBS Letters, Vol. 382, Issue 1-2 https://doi.org/10.1016/0014-5793(96)00137-8	journal	March 1996
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 Martin, George A.; Viskoohil, David; Bollag, Gideon Cell, Vol. 63, Issue 4 https://doi.org/10.1016/0092-8674(90)90150-D	journal	November 1990
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling Schuck, Peter Biophysical Journal, Vol. 78, Issue 3 https://doi.org/10.1016/S0006-3495(00)76713-0	journal	March 2000
Analytical Ultracentrifugation: Sedimentation Velocity and Sedimentation Equilibrium Cole, James L.; Lary, Jeffrey W.; Moody, Thomas P. Biophysical Tools for Biologists, Volume One: In Vitro Techniques, p. 143-179 https://doi.org/10.1016/S0091-679X(07)84006-4	book	January 2008
Differential localization of the neurofibromatosis 1 (NF1) gene product, neurofibromin, with the F-actin or microtubule cytoskeleton during differentiation of telencephalic neurons Li, Chengjun; Cheng, Yu; Gutmann, David A. Developmental Brain Research, Vol. 130, Issue 2 https://doi.org/10.1016/S0165-3806(01)00190-0	journal	October 2001
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation Zhao, Huaying; Ghirlando, Rodolfo; Piszczek, Grzegorz Analytical Biochemistry, Vol. 437, Issue 1 https://doi.org/10.1016/j.ab.2013.02.011	journal	June 2013
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt Boyanapalli, Madanamohan; Lahoud, Oscar B.; Messiaen, Ludwine Biochemical and Biophysical Research Communications, Vol. 340, Issue 4 https://doi.org/10.1016/j.bbrc.2005.12.129	journal	February 2006
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner Agamasu, Constance; Ghirlando, Rodolfo; Taylor, Troy Biophysical Journal, Vol. 116, Issue 6 https://doi.org/10.1016/j.bpj.2019.02.004	journal	March 2019
Engineering the transposition-based baculovirus expression vector system for higher efficiency protein production from insect cells Mehalko, Jennifer L.; Esposito, Dominic Journal of Biotechnology, Vol. 238 https://doi.org/10.1016/j.jbiotec.2016.09.002	journal	November 2016
EMAN2: An extensible image processing suite for electron microscopy Tang, Guang; Peng, Liwei; Baldwin, Philip R. Journal of Structural Biology, Vol. 157, Issue 1 https://doi.org/10.1016/j.jsb.2006.05.009	journal	January 2007
Mantid—Data analysis and visualization package for neutron scattering and μ SR experiments Arnold, O.; Bilheux, J. C.; Borreguero, J. M. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 764 https://doi.org/10.1016/j.nima.2014.07.029	journal	November 2014
Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibromin Bonneau, Fabien; Lenherr, Esther D.; Pena, Vladimir Protein Expression and Purification, Vol. 65, Issue 1 https://doi.org/10.1016/j.pep.2008.12.001	journal	May 2009
The NF1 gene in tumor syndromes and melanoma Kiuru, Maija; Busam, Klaus J. Laboratory Investigation, Vol. 97, Issue 2 https://doi.org/10.1038/labinvest.2016.142	journal	January 2017
Accurate assessment of mass, models and resolution by small-angle scattering Rambo, Robert P.; Tainer, John A. Nature, Vol. 496, Issue 7446 https://doi.org/10.1038/nature12070	journal	April 2013
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas Krauthammer, Michael; Kong, Yong; Bacchiocchi, Antonella Nature Genetics, Vol. 47, Issue 9 https://doi.org/10.1038/ng.3361	journal	July 2015
NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome Eisfeld, Ann-Kathrin; Kohlschmidt, Jessica; Mrózek, Krzysztof Leukemia, Vol. 32, Issue 12 https://doi.org/10.1038/s41375-018-0147-4	journal	June 2018
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway Yang, Han-wei; Hong, Hui-ling; Luo, Wen-wei Acta Pharmacologica Sinica, Vol. 39, Issue 12 https://doi.org/10.1038/s41401-018-0079-6	journal	July 2018
Restoring functional neurofibromin by protein transduction Mellert, K.; Lechner, S.; Lüdeke, M. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-24310-5	journal	April 2018
A novel bipartite phospholipid‐binding module in the neurofibromatosis type 1 protein D'angelo, Igor; Welti, Stefan; Bonneau, Fabien EMBO reports, Vol. 7, Issue 2 https://doi.org/10.1038/sj.embor.7400602	journal	February 2006
Neurofibromatosis Type 1 Protein and Amyloid Precursor Protein Interact in Normal Human Melanocytes and Colocalize with Melanosomes De Schepper, Sofie; Boucneau, Joachim M. A.; Westbroek, Wendy Journal of Investigative Dermatology, Vol. 126, Issue 3 https://doi.org/10.1038/sj.jid.5700087	journal	March 2006
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ Dharmaiah, Srisathiyanarayanan; Bindu, Lakshman; Tran, Timothy H. Proceedings of the National Academy of Sciences, Vol. 113, Issue 44 https://doi.org/10.1073/pnas.1615316113	journal	October 2016
The Motor Protein Kinesin-1 Links Neurofibromin and Merlin in a Common Cellular Pathway of Neurofibromatosis Hakimi, Mohamed-Ali; Speicher, David W.; Shiekhattar, Ramin Journal of Biological Chemistry, Vol. 277, Issue 40 https://doi.org/10.1074/jbc.C200434200	journal	August 2002
Structural analysis of the GAP-related domain from neurofibromin and its implications Scheffzek, K. The EMBO Journal, Vol. 17, Issue 15 https://doi.org/10.1093/emboj/17.15.4313	journal	August 1998
Elucidating the impact of neurofibromatosis-1 germline mutations on neurofibromin function and dopamine-based learning Anastasaki, C.; Woo, A. S.; Messiaen, L. M. Human Molecular Genetics, Vol. 24, Issue 12 https://doi.org/10.1093/hmg/ddv103	journal	March 2015
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1 Stowe, I. B.; Mercado, E. L.; Stowe, T. R. Genes & Development, Vol. 26, Issue 13 https://doi.org/10.1101/gad.190876.112	journal	July 2012
MULCh : modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies Whitten, Andrew E.; Cai, Shuzhi; Trewhella, Jill Journal of Applied Crystallography, Vol. 41, Issue 1 https://doi.org/10.1107/S0021889807055136	journal	January 2008
Absolute calibration of small-angle neutron scattering data Wignall, G. D.; Bates, F. S. Journal of Applied Crystallography, Vol. 20, Issue 1 https://doi.org/10.1107/S0021889887087181	journal	February 1987
The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory Heller, William T.; Urban, Volker S.; Lynn, Gary W. Journal of Applied Crystallography, Vol. 47, Issue 4 https://doi.org/10.1107/S1600576714011285	journal	June 2014
ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions Franke, D.; Petoukhov, M. V.; Konarev, P. V. Journal of Applied Crystallography, Vol. 50, Issue 4 https://doi.org/10.1107/S1600576717007786	journal	June 2017
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients Wallace, M.; Marchuk, D.; Andersen, L. Science, Vol. 249, Issue 4965 https://doi.org/10.1126/science.2134734	journal	July 1990
The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans Phan, Vernon T.; Ding, Vivianne W.; Li, Fenglei Molecular and Cellular Biology, Vol. 30, Issue 9 https://doi.org/10.1128/MCB.01450-08	journal	February 2010
Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer Redig, A. J.; Capelletti, M.; Dahlberg, S. E. Clinical Cancer Research, Vol. 22, Issue 13 https://doi.org/10.1158/1078-0432.CCR-15-2377	journal	February 2016
The NF1 somatic mutational landscape in sporadic human cancers Philpott, Charlotte; Tovell, Hannah; Frayling, Ian M. Human Genomics, Vol. 11, Issue 1 https://doi.org/10.1186/s40246-017-0109-3	journal	June 2017
Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Lamm Equation Modeling and Sedimentation Coefficient Distributions c(s) Dam, Julie; Velikovsky, Carlos A.; Mariuzza, Roy A. Biophysical Journal, Vol. 89, Issue 1 https://doi.org/10.1529/biophysj.105.059568	journal	July 2005
Genome Assembly and Annotation of the Trichoplusia ni Tni-FNL Insect Cell Line Enabled by Long-Read Technologies Talsania, Keyur; Mehta, Monika; Raley, Castle Genes, Vol. 10, Issue 2 https://doi.org/10.3390/genes10020079	journal	January 2019
Affinity Purification of NF1 Protein–Protein Interactors Identifies Keratins and Neurofibromin Itself as Binding Partners Carnes, Rachel M.; Kesterson, Robert A.; Korf, Bruce R. Genes, Vol. 10, Issue 9 https://doi.org/10.3390/genes10090650	journal	August 2019
High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE Moriya, Toshio; Saur, Michael; Stabrin, Markus Journal of Visualized Experiments, Issue 123 https://doi.org/10.3791/55448	journal	January 2017

Similar Records

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Journal Article · 2019 · Journal of Biological Chemistry · OSTI ID:1649499

Sherekar, Mukul; Han, Sae-Won; Ghirlando, Rodolfo; +14 more

The PTEN Tumor Suppressor Forms Homodimers in Solution

Journal Article · 2015 · Structure · OSTI ID:1433724

Heinrich, Frank; Chakravarthy, Srinivas; Nanda, Hirsh; +6 more

The high resolution structure of tyrocidine A reveals an amphipathic dimer

Journal Article · 2014 · Biochimica et Biophysica Acta. Biomembranes · OSTI ID:1773906

Loll, Patrick J.; Upton, Elizabeth C.; Nahoum, Virginie; +2 more

Title: Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Citation Formats

References (42)

Similar Records

Related Subjects