Rationally Programming Nanomaterials with DNA for Biomedical Applications

He, Liangcan; Mu, Jing; Gang, Oleg; Chen, Xiaoyuan

doi:10.1002/advs.202003775

Title: Rationally Programming Nanomaterials with DNA for Biomedical Applications

Journal Article · 23 February 2021 · Advanced Science

DOI: https://doi.org/10.1002/advs.202003775 · OSTI ID:1767300

He, Liangcan ^[1]; Mu, Jing ^[2]; Gang, Oleg ^[3];

^[1]

Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 117597 Singapore
Institute of Precision Medicine Peking University Shenzhen Hospital Shenzhen 518036 China
Department of Chemical Engineering and Department of Applied Physics and Applied Mathematics Columbia University New York NY 10027 USA, Center for Functional Nanomaterials Brookhaven National Laboratory Upton NY 11973 USA

Abstract DNA is not only a carrier of genetic information, but also a versatile structural tool for the engineering and self‐assembling of nanostructures. In this regard, the DNA template has dramatically enhanced the scalability, programmability, and functionality of the self‐assembled DNA nanostructures. These capabilities provide opportunities for a wide range of biomedical applications in biosensing, bioimaging, drug delivery, and disease therapy. In this review, the importance and advantages of DNA for programming and fabricating of DNA nanostructures are first highlighted. The recent progress in design and construction of DNA nanostructures are then summarized, including DNA conjugated nanoparticle systems, DNA‐based clusters and extended organizations, and DNA origami‐templated assemblies. An overview on biomedical applications of the self‐assembled DNA nanostructures is provided. Finally, the conclusion and perspectives on the self‐assembled DNA nanostructures are presented.

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Research Organization:: Columbia Univ., New York, NY (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division

Grant/Contract Number:: SC0008772

OSTI ID:: 1767300

Journal Information:: Advanced Science, Journal Name: Advanced Science Journal Issue: 8 Vol. 8; ISSN 2198-3844

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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