Role of sphingosine‐1‐phosphate receptors in vascular injury of inflammatory bowel disease

Wang, Xuewen; Chen, Shuhua; Xiang, Hong; Liang, Ziwei; Lu, Hongwei

doi:10.1111/jcmm.16333

Title: Role of sphingosine‐1‐phosphate receptors in vascular injury of inflammatory bowel disease

Journal Article · 16 February 2021 · Journal of Cellular and Molecular Medicine

DOI: https://doi.org/10.1111/jcmm.16333 · OSTI ID:1766586

Wang, Xuewen ^[1]; Chen, Shuhua ^[2]; Xiang, Hong ^[3]; Liang, Ziwei ^[4];

^[1]

Center for Experimental Medicine the Third Xiangya Hospital of Central South University Changsha China, Department of Cardiology the Third Xiangya Hospital of Central South University Changsha China
Department of Biochemistry School of Life Sciences of Central South University Changsha China
Center for Experimental Medicine the Third Xiangya Hospital of Central South University Changsha China
Department of Clinical laboratory Yueyang Hospital Affiliated to Hunan Normal University Yueyang China

Abstract Sphingosine‐1‐phosphate receptors (S1PRs) have an impact on the intestinal inflammation of inflammatory bowel disease (IBD) by regulating lymphocyte migration and differentiation. S1PR modulators as an emerging therapeutic approach are being investigated for the treatment of IBD. However, the role of S1PRs in intestinal vessels has not drawn much attention. Intestinal vascular damage is one of the major pathophysiological features of IBD, characterized by increased vascular density and impaired barrier function. S1PRs have pleiotropic effects on vascular endothelial cells, including proliferation, migration, angiogenesis and barrier homeostasis. Mounting evidence shows that S1PRs are abnormally expressed on intestinal vascular endothelial cells in IBD. Unexpectedly, S1PR modulators may damage intestinal vasculature, for example increase intestinal bleeding; therefore, S1PRs are thought to be involved in the regulation of intestinal vascular function in IBD. However, little is understood about how S1PRs regulate intestinal vascular function and participate in the initiation and progression of IBD. In this review, we summarize the pathogenic role of S1PRs in and the underlying mechanisms behind the intestinal vascular injury in IBD in order for improving IBD practice including S1PR‐targeted therapies.

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Sponsoring Organization:: USDOE

OSTI ID:: 1766586

Journal Information:: Journal of Cellular and Molecular Medicine, Journal Name: Journal of Cellular and Molecular Medicine Journal Issue: 6 Vol. 25; ISSN 1582-1838

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

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