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Title: A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Journal Article · · Cancer Cell

Not Available

Sponsoring Organization:
USDOE
OSTI ID:
1734943
Journal Information:
Cancer Cell, Journal Name: Cancer Cell Journal Issue: 6 Vol. 36; ISSN 1535-6108
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (64)

MLL Leukemia and Future Treatment Strategies: MLL Leukemia and Future Treatment Strategies journal March 2015
PBX3 is essential for leukemia stem cell maintenance in MLL -rearranged leukemia: PBX3 is essential for leukemia stem cell maintenance in MLL -rearranged leukemia journal May 2017
MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP journal March 2003
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo journal April 2015
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice journal April 2016
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes journal July 2008
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias journal November 2008
MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L journal July 2011
hDOT1L Links Histone Methylation to Leukemogenesis journal April 2005
The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis journal October 2005
Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia journal January 2017
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia journal January 2017
Chromatin modifications as therapeutic targets in MLL-rearranged leukemia journal November 2012
Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis journal June 2010
Unique and Independent Roles for MLL in Adult Hematopoietic Stem Cells and Progenitors journal September 2007
Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening journal August 2016
A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program journal July 2016
Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia journal November 2016
The MLL recombinome of acute leukemias in 2017 journal July 2017
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 journal July 2006
Integrative genomics viewer journal January 2011
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation journal September 2014
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia journal January 2012
FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis journal January 2012
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes journal June 2003
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia journal December 2001
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia journal March 2015
Fast gapped-read alignment with Bowtie 2 journal March 2012
Full-length RNA-seq from single cells using Smart-seq2 journal January 2014
Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq journal September 2016
MLL translocations, histone modifications and leukaemia stem-cell development journal November 2007
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles journal September 2005
Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation journal April 2011
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration journal April 2012
The Sequence Alignment/Map format and SAMtools journal June 2009
CEAS: cis-regulatory element annotation system journal August 2009
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data journal November 2009
STAR: ultrafast universal RNA-seq aligner journal October 2012
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features journal November 2013
HTSeq--a Python framework to work with high-throughput sequencing data journal September 2014
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling journal November 2006
Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia journal February 2017
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia journal December 2008
The super elongation complex (SEC) and MLL in development and disease journal April 2011
A xenograft model of infant leukaemia reveals a complex MLL translocation journal March 2008
Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications journal December 2005
Variant Review with the Integrative Genomics Viewer journal October 2017
Effective Targeting of the P53–MDM2 Axis in Preclinical Models of Infant MLL -Rearranged Acute Lymphoblastic Leukemia journal January 2015
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia journal August 2016
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia journal February 2018
MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C journal February 2016
Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia journal April 2017
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies journal May 2004
A role for MEIS1 in MLL-fusion gene leukemia journal February 2009
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome journal June 2011
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia journal November 2012
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia journal August 2013
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia journal July 2014
The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse journal June 2002
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 journal December 2014
CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis journal September 2019
The molecular biology of mixed lineage leukemia journal June 2009
Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls journal November 2017
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites journal January 2017