Encapsulation and retention of 225 Ac, 223 Ra, 227 Th, and decay daughters in zircon-type gadolinium vanadate nanoparticles
Abstract
Abstract Unwanted targeting of healthy organs caused by the relocation of radionuclides from the target site has been one of the limiting factors in the widespread application of targeted alpha therapy in patient regimens. GdVO 4 nanoparticles (NPs) were developed as platforms to encapsulate α -emitting radionuclides 223 Ra, 225 Ac, and 227 Th, and retain their decay daughters at the target site. Polycrystalline GdVO 4 NPs with different morphologies and a zircon-type tetragonal crystal structure were obtained by precipitation of GdCl 3 and Na 3 VO 4 in aqueous media at room temperature. The ability of GdVO 4 crystals to host multivalent ions was initially assessed using La, Cs, Bi, Ba, and Pb as surrogates of the radionuclides under investigation. A decrease in Ba encapsulation was obtained after increasing the concentration of surrogate ions, whereas the encapsulation of La cations in GdVO 4 NPs was quantitative (∼100%). Retention of radionuclides was assessed in vitro by dialyzing the radioactive GdVO 4 NPs against deionized water. While 227 Th was quantitatively encapsulated (100%), a partial encapsulation of 223 Ra (∼75%) and 225 Ac (>60%) was observed in GdVO 4 NPs. The maximum leakage of 221 Fr (1st decay daughter of 225more »
- Authors:
-
[1];
[2];
[2];
[3]
- Department of Mechanical and Nuclear Engineering , Virginia Commonwealth University , Richmond , VA , USA, Isotope and Fuel Cycle Technology Division , Oak Ridge National Laboratory , Oak Ridge , TN , USA
- Isotope and Fuel Cycle Technology Division , Oak Ridge National Laboratory , Oak Ridge , TN , USA
- Department of Mechanical and Nuclear Engineering , Virginia Commonwealth University , Richmond , VA , USA
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1734379
- Alternate Identifier(s):
- OSTI ID: 1661262
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Published Article
- Journal Name:
- Radiochimica Acta
- Additional Journal Information:
- Journal Name: Radiochimica Acta Journal Volume: 108 Journal Issue: 12; Journal ID: ISSN 0033-8230
- Publisher:
- Walter de Gruyter GmbH
- Country of Publication:
- Germany
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, and Rojas, Jessika V. Encapsulation and retention of 225 Ac, 223 Ra, 227 Th, and decay daughters in zircon-type gadolinium vanadate nanoparticles. Germany: N. p., 2020.
Web. doi:10.1515/ract-2019-3206.
Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, & Rojas, Jessika V. Encapsulation and retention of 225 Ac, 223 Ra, 227 Th, and decay daughters in zircon-type gadolinium vanadate nanoparticles. Germany. https://doi.org/10.1515/ract-2019-3206
Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, and Rojas, Jessika V. Wed .
"Encapsulation and retention of 225 Ac, 223 Ra, 227 Th, and decay daughters in zircon-type gadolinium vanadate nanoparticles". Germany. https://doi.org/10.1515/ract-2019-3206.
@article{osti_1734379,
title = {Encapsulation and retention of 225 Ac, 223 Ra, 227 Th, and decay daughters in zircon-type gadolinium vanadate nanoparticles},
author = {Toro-González, Miguel and Dame, Ashley N. and Mirzadeh, Saed and Rojas, Jessika V.},
abstractNote = {Abstract Unwanted targeting of healthy organs caused by the relocation of radionuclides from the target site has been one of the limiting factors in the widespread application of targeted alpha therapy in patient regimens. GdVO 4 nanoparticles (NPs) were developed as platforms to encapsulate α -emitting radionuclides 223 Ra, 225 Ac, and 227 Th, and retain their decay daughters at the target site. Polycrystalline GdVO 4 NPs with different morphologies and a zircon-type tetragonal crystal structure were obtained by precipitation of GdCl 3 and Na 3 VO 4 in aqueous media at room temperature. The ability of GdVO 4 crystals to host multivalent ions was initially assessed using La, Cs, Bi, Ba, and Pb as surrogates of the radionuclides under investigation. A decrease in Ba encapsulation was obtained after increasing the concentration of surrogate ions, whereas the encapsulation of La cations in GdVO 4 NPs was quantitative (∼100%). Retention of radionuclides was assessed in vitro by dialyzing the radioactive GdVO 4 NPs against deionized water. While 227 Th was quantitatively encapsulated (100%), a partial encapsulation of 223 Ra (∼75%) and 225 Ac (>60%) was observed in GdVO 4 NPs. The maximum leakage of 221 Fr (1st decay daughter of 225 Ac) was 55.4 ± 3.6%, whereas for 223 Ra (1st decay daughter of 227 Th) the maximum leakage was 73.0 ± 4.0%. These results show the potential of GdVO 4 NPs as platforms of α -emitting radionuclides for their application in targeted alpha therapy.},
doi = {10.1515/ract-2019-3206},
journal = {Radiochimica Acta},
number = 12,
volume = 108,
place = {Germany},
year = {Wed Sep 16 00:00:00 EDT 2020},
month = {Wed Sep 16 00:00:00 EDT 2020}
}
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