Quantitative prediction of repeat dose toxicity values using GenRA

Helman, G.; Patlewicz, G.; Shah, I.

doi:10.1016/j.yrtph.2019.104480

Title: Quantitative prediction of repeat dose toxicity values using GenRA

Full Record
Other Related Research

Authors:

Helman, G.;

;

Publication Date:: 2019-12-01

Sponsoring Org.:: USDOE

OSTI Identifier:: 1703523

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Regulatory Toxicology and Pharmacology

Additional Journal Information:: Journal Name: Regulatory Toxicology and Pharmacology Journal Volume: 109 Journal Issue: C; Journal ID: ISSN 0273-2300

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Citation Formats


                    Helman, G., Patlewicz, G., and Shah, I.. Quantitative prediction of repeat dose toxicity values using GenRA.  United States: N. p., 2019. 
Web.  https://doi.org/10.1016/j.yrtph.2019.104480.

Copy to clipboard


                    Helman, G., Patlewicz, G., & Shah, I.. Quantitative prediction of repeat dose toxicity values using GenRA.  United States.  https://doi.org/10.1016/j.yrtph.2019.104480

Copy to clipboard


                    Helman, G., Patlewicz, G., and Shah, I.. Sun .  
"Quantitative prediction of repeat dose toxicity values using GenRA".  United States.  https://doi.org/10.1016/j.yrtph.2019.104480.

Copy to clipboard


                    
@article{osti_1703523,

  title        = {Quantitative prediction of repeat dose toxicity values using GenRA},

  author       = {Helman, G. and Patlewicz, G. and Shah, I.},

  abstractNote = {},

  doi          = {10.1016/j.yrtph.2019.104480},

  journal      = {Regulatory Toxicology and Pharmacology},

  number       = C,

  volume       = 109,

  place        = {United States},

  year         = {2019},

  month        = {12}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.yrtph.2019.104480

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Structure-based QSAR models to predict repeat dose toxicity points of departure

Journal Article Pradeep, Prachi ; Paul Friedman, Katie ; Judson, Richard - Computational Toxicology
https://doi.org/10.1016/j.comtox.2020.100139
Use of quantitative shape-activity relationships to model the photoinduced toxicity of polycyclic aromatic hydrocarbons: Electron density shape features accurately predict toxicity

Journal Article Mezey, P G ; Zimpel, Z ; Warburton, P ; ... - Environmental Toxicology and Chemistry

The quantitative shape-activity relationship (QShAR) methodology, based on accurate three-dimensional electron densities and detailed shape analysis methods, has been applied to a Lemna gibba photoinduced toxicity data set of 16 polycyclic aromatic hydrocarbon (PAH) molecules. In the first phase of the studies, a shape fragment QShAR database of PAHs was developed. The results provide a very good match to toxicity based on a combination of the local shape features of single rings in comparison to the central ring of anthracene and a more global shape feature involving larger molecular fragments. The local shape feature appears as a descriptor of themore »« less
https://doi.org/10.1897/1551-5028(1998)017<1207:UOQSAR>2.3.CO;2
A Method for the Prediction of Late Organ-at-Risk Toxicity After Radiotherapy of the Prostate Using Equivalent Uniform Dose

Journal Article Fleming, Cathy ; Kelly, Colin ; Thirion, Pierre ; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To evaluate the predictive value of equivalent uniform doses (EUD) for late bladder and rectal toxicity after high-dose three-dimensional conformal radiation therapy (3D-CRT) to the prostate. Materials and Methods: Using the method developed by Kutcher et al., EUDs for whole bladder and rectum were calculated from the dose-volume histograms of 180 patients with localized prostate cancer treated to 70-74 Gy with 3D-CRT. Late complications were recorded using the Radiation Therapy Oncology Group scale, correlated against EUD and known physical predictive indicators. Results: EUD is an independent prognostic factor for Grade 2+ long-term rectal and bladder toxicity after radiation treatmentmore »« less
https://doi.org/10.1016/j.ijrobp.2010.07.1994
Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study

Journal Article Nakayama, Koji ; Kawano, Yukiko ; Kawakami, Yuuki ; ... - Toxicology and Applied Pharmacology

Some compounds have structural isomers of which one is apparently carcinogenic, and the other not. Because of the similarity of their chemical structures, comparisons of their effects can allow gene expression elicited in response to the basic skeletons of the isomers to be disregarded. We compared the gene expression profiles of male Fischer 344 rats administered by daily oral gavage up to 28 days using an in-house oligo microarray. 2-Acetylaminofluorene (2-AAF), 2,4-diaminotoluene (2,4-DAT), 2-nitropropane (2-NP), and 2-nitro-p-phenylenediamine (2-NpP) are hepatocarcinogenic. However, their isomers, 4-acetylaminofluorene (4-AAF), 2,6-diaminotoluene (2,6-DAT), 1-nitropropane (1-NP), and 4-nitro-o-phenylenediamine (4-NoP), are non-hepatocarcinogenic. Because of the limited carcinogenicity ofmore »« less
https://doi.org/10.1016/j.taap.2006.09.008
TOXICITY TESTS OF DECABORANE FOR LABORATORY ANIMALS. II. EFFECT OF REPEATED DOSES

Journal Article Svirbely, J L - Archives of Industrial Health See AMA Arch. Ind. Health

Similar Records