The Effect of Steroids in Patients Undergoing Cardiopulmonary Bypass: An Individual Patient Meta-Analysis of Two Randomized Trials

Whitlock, Richard P.; Dieleman, Jan M.; Belley-Cote, Emilie; Vincent, Jessica; Zhang, Michelle; Devereaux, P. J.; Kalkman, Cor J.; van Dijk, Diederik; Yusuf, Salim

doi:10.1053/j.jvca.2019.06.012

Title: The Effect of Steroids in Patients Undergoing Cardiopulmonary Bypass: An Individual Patient Meta-Analysis of Two Randomized Trials

Journal Article · 31 December 2019 · Journal of Cardiothorac Vascular Anesthesia

DOI: https://doi.org/10.1053/j.jvca.2019.06.012 · OSTI ID:1694010

Whitlock, Richard P.; Dieleman, Jan M.; Belley-Cote, Emilie; Vincent, Jessica; Zhang, Michelle; Devereaux, P. J.; Kalkman, Cor J.; van Dijk, Diederik; Yusuf, Salim

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 1694010

Journal Information:: Journal of Cardiothorac Vascular Anesthesia, Journal Name: Journal of Cardiothorac Vascular Anesthesia Journal Issue: 1 Vol. 34; ISSN 1053-0770

Publisher:: Elsevier BVCopyright Statement

Country of Publication:: United States

Language:: English

References (17)

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Prophylactic corticosteroids for cardiopulmonary bypass in adults Dieleman, Jan M.; van Paassen, Judith; van Dijk, Diederik Cochrane Database of Systematic Reviews https://doi.org/10.1002/14651858.CD005566.pub3	journal	May 2011
Methods for categorizing a prognostic variable in a multivariable setting Mazumdar, Madhu; Smith, Alex; Bacik, Jennifer Statistics in Medicine, Vol. 22, Issue 4 https://doi.org/10.1002/sim.1333	journal	January 2003
Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial Whitlock, Richard P.; Devereaux, P. J.; Teoh, Kevin H. The Lancet, Vol. 386, Issue 10000 https://doi.org/10.1016/S0140-6736(15)00273-1	journal	September 2015
Rationale and design of the Steroids in Cardiac Surgery trial Whitlock, Richard; Teoh, Kevin; Vincent, Jessica American Heart Journal, Vol. 167, Issue 5 https://doi.org/10.1016/j.ahj.2014.01.018	journal	May 2014
Steroids in cardiac surgery: a systematic review and meta-analysis Dvirnik, N.; Belley-Cote, E. P.; Hanif, H. British Journal of Anaesthesia, Vol. 120, Issue 4 https://doi.org/10.1016/j.bja.2017.10.025	journal	April 2018
Consideration of a New Definition of Clinically Relevant Myocardial Infarction After Coronary Revascularization Moussa, Issam D.; Klein, Lloyd W.; Shah, Binita Journal of the American College of Cardiology, Vol. 62, Issue 17 https://doi.org/10.1016/j.jacc.2013.08.720	journal	October 2013
Con: Methylprednisolone is not indicated for patients during cardiopulmonary bypass Sulzer, Christopher F.; Mackensen, G. Burkhard; Grocott, Hilary P. Journal of Cardiothoracic and Vascular Anesthesia, Vol. 19, Issue 2 https://doi.org/10.1053/j.jvca.2005.02.008	journal	April 2005
Pro: Steroids should be used for cardiopulmonary bypass Whitlock, Richard P.; Rubens, Fraser D.; Young, Ed Journal of Cardiothoracic and Vascular Anesthesia, Vol. 19, Issue 2 https://doi.org/10.1053/j.jvca.2005.02.010	journal	April 2005
Steroids and Survival in Critically Ill Adult Patients: A Meta-analysis of 135 Randomized Trials Martino, Enrico A.; Baiardo Redaelli, Martina; Sardo, Salvatore Journal of Cardiothoracic and Vascular Anesthesia, Vol. 32, Issue 5 https://doi.org/10.1053/j.jvca.2018.04.017	journal	October 2018
Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials Whitlock, R. P.; Chan, S.; Devereaux, P. J. European Heart Journal, Vol. 29, Issue 21 https://doi.org/10.1093/eurheartj/ehn333	journal	May 2008
Third universal definition of myocardial infarction Thygesen, Kristian; Alpert, Joseph S.; Jaffe, Allan S. European Heart Journal, Vol. 33, Issue 20 https://doi.org/10.1093/eurheartj/ehs184	journal	August 2012
Steroids in Cardiopulmonary Bypass Vincent, Jean-Louis; Wan, Song; Yim, Anthony P. C. Critical Care Medicine, Vol. 28, Issue 9 https://doi.org/10.1097/00003246-200009000-00060	journal	January 2000
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations Guyatt, Gordon H.; Oxman, Andrew D.; Vist, Gunn E. BMJ, Vol. 336, Issue 7650 https://doi.org/10.1136/bmj.39489.470347.AD	journal	April 2008
Steroid Inhibition of Cytokine-Mediated Vasodilation After Warm Heart Surgery Teoh, Kevin H. T.; Bradley, Christine A.; Gauldie, Jack Circulation, Vol. 92, Issue 9 https://doi.org/10.1161/01.CIR.92.9.347	journal	November 1995
Benefits and Risks of Corticosteroid Prophylaxis in Adult Cardiac Surgery: A Dose-Response Meta-Analysis Ho, Kwok M.; Tan, Jen Aik Circulation, Vol. 119, Issue 14 https://doi.org/10.1161/CIRCULATIONAHA.108.848218	journal	April 2009
Corticosteroids and Cardiopulmonary Bypass Chaney, Mark A. Chest, Vol. 121, Issue 3 https://doi.org/10.1378/chest.121.3.921	journal	March 2002

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Title: The Effect of Steroids in Patients Undergoing Cardiopulmonary Bypass: An Individual Patient Meta-Analysis of Two Randomized Trials

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