Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway

Zhou, Jia-yi; Lin, Hua-lin; Wang, Zhe; Zhang, Sai-wu; Huang, Deng-gui; Gao, Chun-qi; Yan, Hui-chao; Wang, Xiu-qi

doi:10.1016/j.envpol.2020.114290

Title: Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway

Authors:: Zhou, Jia-yi; Lin, Hua-lin; Wang, Zhe; Zhang, Sai-wu; Huang, Deng-gui; Gao, Chun-qi; Yan, Hui-chao; Wang, Xiu-qi

Publication Date:: Wed Jul 01 00:00:00 EDT 2020

Sponsoring Org.:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:: 1691803

Grant/Contract Number:: 2019B020218001

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Environmental Pollution

Additional Journal Information:: Journal Name: Environmental Pollution Journal Volume: 262 Journal Issue: C; Journal ID: ISSN 0269-7491

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Zhou, Jia-yi, Lin, Hua-lin, Wang, Zhe, Zhang, Sai-wu, Huang, Deng-gui, Gao, Chun-qi, Yan, Hui-chao, and Wang, Xiu-qi. Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway.  United Kingdom: N. p., 2020. 
Web.  doi:10.1016/j.envpol.2020.114290.

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                    Zhou, Jia-yi, Lin, Hua-lin, Wang, Zhe, Zhang, Sai-wu, Huang, Deng-gui, Gao, Chun-qi, Yan, Hui-chao, & Wang, Xiu-qi. Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway.  United Kingdom.  https://doi.org/10.1016/j.envpol.2020.114290

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                    Zhou, Jia-yi, Lin, Hua-lin, Wang, Zhe, Zhang, Sai-wu, Huang, Deng-gui, Gao, Chun-qi, Yan, Hui-chao, and Wang, Xiu-qi. Wed .  
"Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway".  United Kingdom.  https://doi.org/10.1016/j.envpol.2020.114290.

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@article{osti_1691803,

  title        = {Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway},

  author       = {Zhou, Jia-yi and Lin, Hua-lin and Wang, Zhe and Zhang, Sai-wu and Huang, Deng-gui and Gao, Chun-qi and Yan, Hui-chao and Wang, Xiu-qi},

  abstractNote = {},

  doi          = {10.1016/j.envpol.2020.114290},

  journal      = {Environmental Pollution},

  number       = C,

  volume       = 262,

  place        = {United Kingdom},

  year         = {Wed Jul 01 00:00:00 EDT 2020},

  month        = {Wed Jul 01 00:00:00 EDT 2020}

}

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Works referenced in this record:

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Title: Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway

Citation Formats

Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative escherichia coli -induced diarrhea journal, September 2014

Mechanisms regulating intestinal barrier integrity and its pathological implications journal, August 2018

High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses journal, October 2015

CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways journal, November 2017

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells journal, September 2008

Tales from the crypt: new insights into intestinal stem cells journal, November 2018

Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury journal, September 2016

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration journal, November 2017

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22 journal, February 2018

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production journal, August 2019

Deoxynivalenol induces apoptosis and disrupts cellular homeostasis through MAPK signaling pathways in bovine mammary epithelial cells journal, September 2019

Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells1 journal, January 2014

LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/β-Catenin Signaling journal, March 2018

Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway journal, May 2019

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life journal, January 2013

Zinc and Oxidative Stress: Current Mechanisms journal, March 2017

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration journal, February 2014

Deoxynivalenol: Toxicology and Potential Effects on Humans journal, December 2005

ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice journal, May 2016

Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα journal, June 2013

A survey of trichothecenes, zearalenone and patulin in milled grain-based products using GC–MS/MS journal, March 2014

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts journal, November 2010

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells journal, May 2017

Zinc protects against indomethacin-induced damage in the rat small intestine journal, March 2011

Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis journal, May 2017

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression journal, August 2017

Deoxynivalenol induces inhibition of cell proliferation via the Wnt/β-catenin signaling pathway journal, August 2019

Zinc Aspartate Alleviates Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats journal, January 2009

Transient fluctuations of intracellular zinc ions in cell proliferation journal, August 2009

Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers journal, August 2012

The downregulation of Wnt/β-catenin signaling pathway is associated with zinc deficiency-induced proliferative deficit of C17.2 neural stem cells journal, July 2015

Methionine and Its Hydroxyl Analogues Improve Stem Cell Activity To Eliminate Deoxynivalenol-Induced Intestinal Injury by Reactivating Wnt/β-Catenin Signaling journal, September 2019

Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice journal, September 2019

mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation journal, April 2019

Extracellular Glutamate-Induced mTORC1 Activation via the IR/IRS/PI3K/Akt Pathway Enhances the Expansion of Porcine Intestinal Stem Cells journal, August 2019

Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative escherichia coli -induced diarrhea
journal, September 2014

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journal, August 2018

High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses
journal, October 2015

CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways
journal, November 2017

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells
journal, September 2008

Tales from the crypt: new insights into intestinal stem cells
journal, November 2018

Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury
journal, September 2016

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
journal, November 2017

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22
journal, February 2018

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production
journal, August 2019

Deoxynivalenol induces apoptosis and disrupts cellular homeostasis through MAPK signaling pathways in bovine mammary epithelial cells
journal, September 2019

Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells1
journal, January 2014

LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/β-Catenin Signaling
journal, March 2018

Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway
journal, May 2019

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life
journal, January 2013

Zinc and Oxidative Stress: Current Mechanisms
journal, March 2017

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration
journal, February 2014

Deoxynivalenol: Toxicology and Potential Effects on Humans
journal, December 2005

ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice
journal, May 2016

Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα
journal, June 2013

A survey of trichothecenes, zearalenone and patulin in milled grain-based products using GC–MS/MS
journal, March 2014

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
journal, November 2010

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells
journal, May 2017

Zinc protects against indomethacin-induced damage in the rat small intestine
journal, March 2011

Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis
journal, May 2017

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression
journal, August 2017

Deoxynivalenol induces inhibition of cell proliferation via the Wnt/β-catenin signaling pathway
journal, August 2019

Zinc Aspartate Alleviates Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats
journal, January 2009

Transient fluctuations of intracellular zinc ions in cell proliferation
journal, August 2009

Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers
journal, August 2012

The downregulation of Wnt/β-catenin signaling pathway is associated with zinc deficiency-induced proliferative deficit of C17.2 neural stem cells
journal, July 2015

Methionine and Its Hydroxyl Analogues Improve Stem Cell Activity To Eliminate Deoxynivalenol-Induced Intestinal Injury by Reactivating Wnt/β-Catenin Signaling
journal, September 2019

Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice
journal, September 2019

mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation
journal, April 2019

Extracellular Glutamate-Induced mTORC1 Activation via the IR/IRS/PI3K/Akt Pathway Enhances the Expansion of Porcine Intestinal Stem Cells
journal, August 2019