Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Abel, E. Paige; Domnanich, Katharina; Clause, Hannah K.; Kalman, Colton; Walker, Wes; Shusterman, Jennifer A.; Greene, John; Gott, Matthew; Severin, Gregory W.

doi:10.1021/acsomega.0c03020

Title: Production, Collection, and Purification of ⁴⁷ Ca for the Generation of ⁴⁷ Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Abstract

An experiment was performed at the National Superconducting Cyclotron Laboratory using a 140 MeV/nucleon 48Ca beam and a flowing-water target to produce 47Ca for the first time with this production route. A production rate of 0.020 ± 0.004 47Ca per incoming beam particle was measured. An isotope harvesting system attached to the target was used to collect radioactive cationic products, including 47Ca, from the water on a cation exchange resin. The 47Ca collected was purified using three separation methods optimized for this work: 1) DGA resin with HNO3 and HCl, 2) AG MP-50 cation exchange resin with an increasing concentration gradient of HCl, and 3) AG MP-50 resin with a methanolic HCl gradient. These methods resulted in ≥99 ± 2% separation yield of 47Ca with 100% radionuclidic purity within the limits of detection for HPGe measurements. ICP-OES was used to identify low levels of stable ions in the water of the isotope harvesting system during the irradiation and in the final purified solution of 47Ca. For the first time, this experiment demonstrated the feasibility of production, collection, and purification of 47Ca through isotope harvesting for the generation of 47Sc for nuclear medicine applications.

Authors:

Abel, E. Paige ^[1]; Domnanich, Katharina ^[1]; Clause, Hannah K. ^[1]; Kalman, Colton ^[2]; Walker, Wes ^[2]; Shusterman, Jennifer A. ^[3]; Greene, John ^[4]; Gott, Matthew ^[4];

^[1]

Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, United States
National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, United States
Department of Chemistry, Hunter College of the City University of New York, New York, New York 10065, United States, Ph. D. Program in Chemistry, The Graduate Center of the City of New York, New York, New York 10016, United States
Physics Division, Argonne National Laboratory, Lemont, Illinois 60439, United States

Publication Date:: Thu Oct 22 00:00:00 EDT 2020

Research Org.:: Michigan State Univ., East Lansing, MI (United States); Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP); USDOE National Nuclear Security Administration (NNSA)

OSTI Identifier:: 1682510

Alternate Identifier(s):: OSTI ID: 1699394; OSTI ID: 1762262

Grant/Contract Number:: AC02-06CH11357; SC0018637; NA0003864

Resource Type:: Published Article

Journal Name:: ACS Omega

Additional Journal Information:: Journal Name: ACS Omega Journal Volume: 5 Journal Issue: 43; Journal ID: ISSN 2470-1343

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Alcohols; Organic polymers; Ions; Isotopes; Irradiation

Citation Formats


                    Abel, E. Paige, Domnanich, Katharina, Clause, Hannah K., Kalman, Colton, Walker, Wes, Shusterman, Jennifer A., Greene, John, Gott, Matthew, and Severin, Gregory W. Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory.  United States: N. p., 2020. 
Web.  doi:10.1021/acsomega.0c03020.

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                    Abel, E. Paige, Domnanich, Katharina, Clause, Hannah K., Kalman, Colton, Walker, Wes, Shusterman, Jennifer A., Greene, John, Gott, Matthew, & Severin, Gregory W. Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory.  United States.  https://doi.org/10.1021/acsomega.0c03020

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                    Abel, E. Paige, Domnanich, Katharina, Clause, Hannah K., Kalman, Colton, Walker, Wes, Shusterman, Jennifer A., Greene, John, Gott, Matthew, and Severin, Gregory W. Thu .  
"Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory".  United States.  https://doi.org/10.1021/acsomega.0c03020.

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@article{osti_1682510,

  title        = {Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory},

  author       = {Abel, E. Paige and Domnanich, Katharina and Clause, Hannah K. and Kalman, Colton and Walker, Wes and Shusterman, Jennifer A. and Greene, John and Gott, Matthew and Severin, Gregory W.},

  abstractNote = {An experiment was performed at the National Superconducting Cyclotron Laboratory using a 140 MeV/nucleon 48Ca beam and a flowing-water target to produce 47Ca for the first time with this production route. A production rate of 0.020 ± 0.004 47Ca per incoming beam particle was measured. An isotope harvesting system attached to the target was used to collect radioactive cationic products, including 47Ca, from the water on a cation exchange resin. The 47Ca collected was purified using three separation methods optimized for this work: 1) DGA resin with HNO3 and HCl, 2) AG MP-50 cation exchange resin with an increasing concentration gradient of HCl, and 3) AG MP-50 resin with a methanolic HCl gradient. These methods resulted in ≥99 ± 2% separation yield of 47Ca with 100% radionuclidic purity within the limits of detection for HPGe measurements. ICP-OES was used to identify low levels of stable ions in the water of the isotope harvesting system during the irradiation and in the final purified solution of 47Ca. For the first time, this experiment demonstrated the feasibility of production, collection, and purification of 47Ca through isotope harvesting for the generation of 47Sc for nuclear medicine applications.},

  doi          = {10.1021/acsomega.0c03020},

  journal      = {ACS Omega},

  number       = 43,

  volume       = 5,

  place        = {United States},

  year         = {Thu Oct 22 00:00:00 EDT 2020},

  month        = {Thu Oct 22 00:00:00 EDT 2020}

}

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Title: Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Abstract

Citation Formats

Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets journal, January 2018

Nuclear Data Sheets for A = 27 journal, August 2011

Influence of diluent on radiolysis of amides in organic solution journal, May 2007

Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc journal, March 2015

Clinical Translation and First In-Human Use of [ 44 Sc]Sc-PSMA-617 for PET Imaging of Metastasized Castrate-Resistant Prostate Cancer journal, January 2017

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Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations journal, August 2019

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Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice journal, July 2014

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47Sc production development by cyclotron irradiation of 48Ca journal, June 2017

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First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44 Sc-DOTATOC: A Proof-of-Concept Study journal, May 2017

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Title: Production, Collection, and Purification of ⁴⁷ Ca for the Generation of ⁴⁷ Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets
journal, January 2018

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journal, October 2008

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journal, May 1977

First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced ⁴⁴ Sc-DOTATOC: A Proof-of-Concept Study
journal, May 2017

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Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory
journal, May 2014

Need satisfaction and the self-regulation of learning
journal, January 1996

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journal, November 2013

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journal, October 2014

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journal, April 2020

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Novel Extraction of Chromatographic Resins Based on Tetraalkyldiglycolamides: Characterization and Potential Applications
journal, May 2005

Radiolysis and radionuclide production in a flowing-water target during fast 40Ca20+ irradiation.
journal, April 2020

Features of Particle and Heavy Ion Transport code System (PHITS) version 3.02
journal, January 2018

Nuclear Data Sheets for A = 44
journal, September 2011

Nuclear Data Sheets Update for A = 46
journal, February 1993