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Title: Dynamics of Phospholipid Membranes beyond Thermal Undulations

Abstract

Here, we investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length scale of the size of the headgroup of a lipid. The associated mean squared displacement shows a t0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman–Granek (ZG) model (t0.66) and translational diffusion (t1). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model. The analysis of the mean squared displacement leads to the important conclusion that the friction at the interface between water and liposomes plays a minor role. Center of mass diffusion of liposomes and transient trapping of lipids define the range in which the ZG model can be applied to analyze membrane fluctuations.

Authors:
ORCiD logo [1];  [1];  [1];  [2];  [3]; ORCiD logo [3];  [1]
  1. Louisiana State Univ., Baton Rouge, LA (United States)
  2. Jülich Centre for Neutron Science (JCNS), Oak Ridge, TN (United States)
  3. National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States)
Publication Date:
Research Org.:
Louisiana State Univ., Baton Rouge, LA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1673736
Alternate Identifier(s):
OSTI ID: 1673738
Grant/Contract Number:  
SC0012432
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Physical Chemistry Letters
Additional Journal Information:
Journal Volume: 9; Journal Issue: 11; Journal ID: ISSN 1948-7185
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Vesicles; Lipids; Diffusion; Dynamic light scattering; Membranes

Citation Formats

Gupta, Sudipta, De Mel, Judith U., Perera, Rasangi M., Zolnierczuk, Piotr, Bleuel, Markus, Faraone, Antonio, and Schneider, Gerald J. Dynamics of Phospholipid Membranes beyond Thermal Undulations. United States: N. p., 2018. Web. doi:10.1021/acs.jpclett.8b01008.
Gupta, Sudipta, De Mel, Judith U., Perera, Rasangi M., Zolnierczuk, Piotr, Bleuel, Markus, Faraone, Antonio, & Schneider, Gerald J. Dynamics of Phospholipid Membranes beyond Thermal Undulations. United States. https://doi.org/10.1021/acs.jpclett.8b01008
Gupta, Sudipta, De Mel, Judith U., Perera, Rasangi M., Zolnierczuk, Piotr, Bleuel, Markus, Faraone, Antonio, and Schneider, Gerald J. Sat . "Dynamics of Phospholipid Membranes beyond Thermal Undulations". United States. https://doi.org/10.1021/acs.jpclett.8b01008. https://www.osti.gov/servlets/purl/1673736.
@article{osti_1673736,
title = {Dynamics of Phospholipid Membranes beyond Thermal Undulations},
author = {Gupta, Sudipta and De Mel, Judith U. and Perera, Rasangi M. and Zolnierczuk, Piotr and Bleuel, Markus and Faraone, Antonio and Schneider, Gerald J.},
abstractNote = {Here, we investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length scale of the size of the headgroup of a lipid. The associated mean squared displacement shows a t0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman–Granek (ZG) model (t0.66) and translational diffusion (t1). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model. The analysis of the mean squared displacement leads to the important conclusion that the friction at the interface between water and liposomes plays a minor role. Center of mass diffusion of liposomes and transient trapping of lipids define the range in which the ZG model can be applied to analyze membrane fluctuations.},
doi = {10.1021/acs.jpclett.8b01008},
journal = {Journal of Physical Chemistry Letters},
number = 11,
volume = 9,
place = {United States},
year = {2018},
month = {5}
}

Journal Article:
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Cited by: 49 works
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Figures / Tables:

Figure 1 Figure 1: (a) The dynamic structure factor, S($Q$,t)/S($Q$), from DLS autocorrelation function as a function of time. (b) SANS scattering intensity for, $\phi_w$ = 5% and 0.25% DOPC dispersed in D2O. The solid line represents the vesicle form factor. Inset: Cryo-TEM image.

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