skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs

Authors:
; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1668876
Resource Type:
Published Article
Journal Name:
Bioorganic and Medicinal Chemistry
Additional Journal Information:
Journal Name: Bioorganic and Medicinal Chemistry Journal Volume: 28 Journal Issue: 22; Journal ID: ISSN 0968-0896
Publisher:
Elsevier
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Grajkowski, Andrzej, Takahashi, Mayumi, Cawrse, Brian M., and Beaucage, Serge L.. An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs. United Kingdom: N. p., 2020. Web. https://doi.org/10.1016/j.bmc.2020.115779.
Grajkowski, Andrzej, Takahashi, Mayumi, Cawrse, Brian M., & Beaucage, Serge L.. An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs. United Kingdom. https://doi.org/10.1016/j.bmc.2020.115779
Grajkowski, Andrzej, Takahashi, Mayumi, Cawrse, Brian M., and Beaucage, Serge L.. Sun . "An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs". United Kingdom. https://doi.org/10.1016/j.bmc.2020.115779.
@article{osti_1668876,
title = {An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs},
author = {Grajkowski, Andrzej and Takahashi, Mayumi and Cawrse, Brian M. and Beaucage, Serge L.},
abstractNote = {},
doi = {10.1016/j.bmc.2020.115779},
journal = {Bioorganic and Medicinal Chemistry},
number = 22,
volume = 28,
place = {United Kingdom},
year = {2020},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.bmc.2020.115779

Save / Share:

Works referenced in this record:

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies
journal, October 2015


Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers
journal, October 2016

  • Crooke, Stanley T.; Baker, Brenda F.; Kwoh, T. Jesse
  • Molecular Therapy, Vol. 24, Issue 10
  • DOI: 10.1038/mt.2016.136

H-phosphonate oligonucleotide synthesis on a polyethylen glycol/polystyrene copolymer
journal, September 1991


Synthesis of full-length oligonucleotides: cleavage of apurinic molecules on a novel support
journal, December 1996


Safety of antisense oligonucleotide and siRNA-based therapeutics
journal, May 2017


RNA interference-based therapy and its delivery systems
journal, December 2017

  • Chen, Xiuhui; Mangala, Lingegowda S.; Rodriguez-Aguayo, Cristian
  • Cancer and Metastasis Reviews, Vol. 37, Issue 1
  • DOI: 10.1007/s10555-017-9717-6

Solid-Phase Purification of Synthetic DNA Sequences
journal, July 2016

  • Grajkowski, Andrzej; Cieslak, Jacek; Beaucage, Serge L.
  • The Journal of Organic Chemistry, Vol. 81, Issue 15
  • DOI: 10.1021/acs.joc.6b01020

Sequence identity of the n -1 product of a synthetic oligonucleotide
journal, January 1995

  • Temsamani, Jamal; Kubert, Michael; Agrawal, Sudhir
  • Nucleic Acids Research, Vol. 23, Issue 11
  • DOI: 10.1093/nar/23.11.1841

The effect of spacer, linkage and solid support on the synthesis of oligonucleotides
journal, January 1989


HELP (High Efficiency Liquid Phase) new oligonucleotide synthesis on soluble polymeric support
journal, January 1990

  • Bonora, Gian Maria; Scremin, Carlo Luigi; Colonna, Francesco Paolo
  • Nucleic Acids Research, Vol. 18, Issue 11
  • DOI: 10.1093/nar/18.11.3155