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Title: Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury

Authors:
 [1];  [2];  [2];  [2];  [3];  [4]
  1. Department of Hand Surgery China‐Japan Union Hospital of Jilin University Changchun China, Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co‐innovation Center of Neuroregeneration Nantong University Nantong China
  2. Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co‐innovation Center of Neuroregeneration Nantong University Nantong China
  3. Department of Hand Surgery China‐Japan Union Hospital of Jilin University Changchun China
  4. Department of Tissue and Embryology, Medical School of Nantong University, Co‐innovation Center of Neuroregeneration Nantong University Nantong China, Department of Anesthesiology Affiliated Hospital of Nantong University Nantong China
Publication Date:
Sponsoring Org.:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI Identifier:
1665925
Alternate Identifier(s):
OSTI ID: 1786922
Grant/Contract Number:  
2017YFA0104704; BK20181460; 17KJA180009
Resource Type:
Published Article
Journal Name:
FASEB Journal
Additional Journal Information:
Journal Name: FASEB Journal Journal Volume: 34 Journal Issue: 11; Journal ID: ISSN 0892-6638
Publisher:
FASEB
Country of Publication:
United States
Language:
English

Citation Formats

Yang, Tuo, Xing, Lingyan, Yu, Weiwei, Cai, Yunyun, Cui, Shusen, and Chen, Gang. Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury. United States: N. p., 2020. Web. https://doi.org/10.1096/fj.202001657RR.
Yang, Tuo, Xing, Lingyan, Yu, Weiwei, Cai, Yunyun, Cui, Shusen, & Chen, Gang. Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury. United States. https://doi.org/10.1096/fj.202001657RR
Yang, Tuo, Xing, Lingyan, Yu, Weiwei, Cai, Yunyun, Cui, Shusen, and Chen, Gang. Fri . "Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury". United States. https://doi.org/10.1096/fj.202001657RR.
@article{osti_1665925,
title = {Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury},
author = {Yang, Tuo and Xing, Lingyan and Yu, Weiwei and Cai, Yunyun and Cui, Shusen and Chen, Gang},
abstractNote = {},
doi = {10.1096/fj.202001657RR},
journal = {FASEB Journal},
number = 11,
volume = 34,
place = {United States},
year = {2020},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1096/fj.202001657RR

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Works referenced in this record:

Astrocyte-Specific Deletion of Sox2 Promotes Functional Recovery After Traumatic Brain Injury
journal, November 2017

  • Chen, Chunhai; Zhong, Xiaoling; Smith, Derek K.
  • Cerebral Cortex, Vol. 29, Issue 1
  • DOI: 10.1093/cercor/bhx303

Neuroregeneration using in vivo cellular reprogramming
journal, January 2017


Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
journal, January 2008

  • Courtine, Gregoire; Song, Bingbing; Roy, Roland R.
  • Nature Medicine, Vol. 14, Issue 1
  • DOI: 10.1038/nm1682

Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury
journal, January 2018

  • Wang, Lin; Pei, Shuang; Han, Linlin
  • Cellular Physiology and Biochemistry, Vol. 50, Issue 4
  • DOI: 10.1159/000494652

The Chondroitin Sulfate Proteoglycans Neurocan and Phosphacan Are Expressed by Reactive Astrocytes in the Chronic CNS Glial Scar
journal, December 1999


Proliferating NG2-Cell-Dependent Angiogenesis and Scar Formation Alter Axon Growth and Functional Recovery After Spinal Cord Injury in Mice
journal, December 2017


Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine
journal, May 2009


Astrocyte barriers to neurotoxic inflammation
journal, April 2015

  • Sofroniew, Michael V.
  • Nature Reviews Neuroscience, Vol. 16, Issue 5
  • DOI: 10.1038/nrn3898

OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts
journal, August 2017


Novel Speed-Controlled Automated Ladder Walking Device Reveals Walking Speed as a Critical Determinant of Skilled Locomotion after a Spinal Cord Injury in Adult Rats
journal, September 2019

  • Richards, Tiffany M.; Sharma, Pawan; Kuang, Aaron
  • Journal of Neurotrauma, Vol. 36, Issue 18
  • DOI: 10.1089/neu.2018.6152

The swimming test is effective for evaluating spasticity after contusive spinal cord injury
journal, February 2017


The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
journal, August 2003


Astrocyte scar formation aids central nervous system axon regeneration
journal, March 2016

  • Anderson, Mark A.; Burda, Joshua E.; Ren, Yilong
  • Nature, Vol. 532, Issue 7598
  • DOI: 10.1038/nature17623

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury
journal, September 2013


Animal models of axon regeneration after spinal cord injury
journal, July 2013


Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury
journal, March 2019

  • Xu, An-Kai; Gong, Zhe; He, Yu-Zhe
  • Journal of Zhejiang University-SCIENCE B, Vol. 20, Issue 3
  • DOI: 10.1631/jzus.B1800280

The diversity and disparity of the glial scar
journal, December 2017


Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury
journal, April 2019


Questions and (some) answers on reactive astrocytes
journal, July 2019

  • Escartin, Carole; Guillemaud, Océane; Carrillo‐de Sauvage, Maria‐Angeles
  • Glia, Vol. 67, Issue 12
  • DOI: 10.1002/glia.23687

Spinal cord Regeneration in the rat
journal, January 1940


Novel Direct Conversion of Microglia to Neurons
journal, February 2019


Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
journal, March 2000


Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury
journal, July 2015


Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses
journal, April 2013

  • Shigetomi, Eiji; Bushong, Eric A.; Haustein, Martin D.
  • The Journal of General Physiology, Vol. 141, Issue 5
  • DOI: 10.1085/jgp.201210949

Strain-dependent recovery of spontaneous hindlimb movement in spinal cord transected mice (CD1, C57BL/6, BALB/c).
journal, January 2006


Cell biology of spinal cord injury and repair
journal, July 2017

  • O’Shea, Timothy M.; Burda, Joshua E.; Sofroniew, Michael V.
  • Journal of Clinical Investigation, Vol. 127, Issue 9
  • DOI: 10.1172/JCI90608

Epidemiology, Demographics, and Pathophysiology of Acute Spinal Cord Injury
journal, January 2001


Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
journal, May 2012


Conditional ablation of reactive astrocytes to dissect their roles in spinal cord injury and repair
journal, August 2019


Current Options for Cell Therapy in Spinal Cord Injury
journal, September 2017


Required growth facilitators propel axon regeneration across complete spinal cord injury
journal, August 2018


Regeneration of severed nerve fibers in the spinal cord of the adult cat
journal, December 1954

  • Clemente, Carmine D.; Windle, William F.
  • The Journal of Comparative Neurology, Vol. 101, Issue 3
  • DOI: 10.1002/cne.901010304

Dissecting spinal cord regeneration
journal, May 2018


Spinal cord repair: advances in biology and technology
journal, June 2019


In vivo conversion of astrocytes to neurons in the injured adult spinal cord
journal, February 2014

  • Su, Zhida; Niu, Wenze; Liu, Meng-Lu
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4338

Regenerative Therapies for Spinal Cord Injury
journal, December 2019

  • Ashammakhi, Nureddin; Kim, Han-Jun; Ehsanipour, Arshia
  • Tissue Engineering Part B: Reviews, Vol. 25, Issue 6
  • DOI: 10.1089/ten.teb.2019.0182

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury
journal, March 2004


Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
journal, March 2018


SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain
journal, May 2015


Adult neurogenesis from reprogrammed astrocytes
journal, January 2020

  • Griffiths, BrianB; Bhutani, Anvee; Stary, CreedM
  • Neural Regeneration Research, Vol. 15, Issue 6
  • DOI: 10.4103/1673-5374.270292