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Title: Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools

Abstract

Specific lipid and protein changes characterized term preeclampsia (PRE) and gestational diabetes mellitus (GDM) and novel visualization tools were created to aid in the process.

Authors:
ORCiD logo [1];  [2];  [3];  [2];  [4];  [3];  [3];  [3];  [3];  [5];  [5];  [6]; ORCiD logo [7]; ORCiD logo [8]
  1. Department of Chemistry, North Carolina State University, Raleigh, USA
  2. National Security Division, Pacific Northwest National Laboratory, Richland, USA
  3. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
  4. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA, Department of Biostatistics and Informatics
  5. Department of Chemistry, North Carolina State University, Raleigh, USA, Bioinformatics Research Center
  6. College of Public Health, Temple University, Philadelphia, USA
  7. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, USA
  8. Department of Chemistry, North Carolina State University, Raleigh, USA, Comparative Medicine Institute
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1664579
Grant/Contract Number:  
AC05-76RLO 1830
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Molecular Omics
Additional Journal Information:
Journal Name: Molecular Omics Journal Volume: 16 Journal Issue: 6; Journal ID: ISSN 2515-4184
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Odenkirk, Melanie T., Stratton, Kelly G., Gritsenko, Marina A., Bramer, Lisa M., Webb-Robertson, Bobbie-Jo M., Bloodsworth, Kent J., Weitz, Karl K., Lipton, Anna K., Monroe, Matthew E., Ash, Jeremy R., Fourches, Denis, Taylor, Brandie D., Burnum-Johnson, Kristin E., and Baker, Erin S.. Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools. United Kingdom: N. p., 2020. Web. https://doi.org/10.1039/D0MO00074D.
Odenkirk, Melanie T., Stratton, Kelly G., Gritsenko, Marina A., Bramer, Lisa M., Webb-Robertson, Bobbie-Jo M., Bloodsworth, Kent J., Weitz, Karl K., Lipton, Anna K., Monroe, Matthew E., Ash, Jeremy R., Fourches, Denis, Taylor, Brandie D., Burnum-Johnson, Kristin E., & Baker, Erin S.. Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools. United Kingdom. https://doi.org/10.1039/D0MO00074D
Odenkirk, Melanie T., Stratton, Kelly G., Gritsenko, Marina A., Bramer, Lisa M., Webb-Robertson, Bobbie-Jo M., Bloodsworth, Kent J., Weitz, Karl K., Lipton, Anna K., Monroe, Matthew E., Ash, Jeremy R., Fourches, Denis, Taylor, Brandie D., Burnum-Johnson, Kristin E., and Baker, Erin S.. Mon . "Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools". United Kingdom. https://doi.org/10.1039/D0MO00074D.
@article{osti_1664579,
title = {Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools},
author = {Odenkirk, Melanie T. and Stratton, Kelly G. and Gritsenko, Marina A. and Bramer, Lisa M. and Webb-Robertson, Bobbie-Jo M. and Bloodsworth, Kent J. and Weitz, Karl K. and Lipton, Anna K. and Monroe, Matthew E. and Ash, Jeremy R. and Fourches, Denis and Taylor, Brandie D. and Burnum-Johnson, Kristin E. and Baker, Erin S.},
abstractNote = {Specific lipid and protein changes characterized term preeclampsia (PRE) and gestational diabetes mellitus (GDM) and novel visualization tools were created to aid in the process.},
doi = {10.1039/D0MO00074D},
journal = {Molecular Omics},
number = 6,
volume = 16,
place = {United Kingdom},
year = {2020},
month = {12}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1039/D0MO00074D

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Works referenced in this record:

Low alpha-synuclein levels in the blood are associated with insulin resistance
journal, July 2015

  • Rodriguez-Araujo, Gerardo; Nakagami, Hironori; Takami, Yoichi
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep12081

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures
journal, July 2007

  • Baker, Erin Shammel; Clowers, Brian H.; Li, Fumin
  • Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 7, p. 1176-1187
  • DOI: 10.1016/j.jasms.2007.03.031

STRING v10: protein–protein interaction networks, integrated over the tree of life
journal, October 2014

  • Szklarczyk, Damian; Franceschini, Andrea; Wyder, Stefan
  • Nucleic Acids Research, Vol. 43, Issue D1
  • DOI: 10.1093/nar/gku1003

C-Reactive Protein and Its Role in Preeclampsia
journal, February 2015


Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis
journal, November 2013

  • Ananth, C. V.; Keyes, K. M.; Wapner, R. J.
  • BMJ, Vol. 347, Issue nov07 15
  • DOI: 10.1136/bmj.f6564

The degradation of nucleotide triphosphates extracted under boiling ethanol conditions is prevented by the yeast cellular matrix
journal, November 2016


Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy
journal, August 2011

  • Hutcheon, Jennifer A.; Lisonkova, Sarka; Joseph, K. S.
  • Best Practice & Research Clinical Obstetrics & Gynaecology, Vol. 25, Issue 4
  • DOI: 10.1016/j.bpobgyn.2011.01.006

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
journal, May 2018

  • Chong, Jasmine; Soufan, Othman; Li, Carin
  • Nucleic Acids Research, Vol. 46, Issue W1
  • DOI: 10.1093/nar/gky310

Preeclampsia Is Characterized by Placental Complement Dysregulation
journal, November 2012


Triglycerides and HDL Cholesterol: Stars or second leads in diabetes?
journal, October 2009

  • Bitzur, R.; Cohen, H.; Kamari, Y.
  • Diabetes Care, Vol. 32, Issue suppl_2
  • DOI: 10.2337/dc09-S343

VIBE 2.0: Visual Integration for Bayesian Evaluation
journal, November 2009


KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model
journal, January 2014

  • Du, Junli; Yuan, Zhifa; Ma, Ziwei
  • Mol. BioSyst., Vol. 10, Issue 9
  • DOI: 10.1039/C4MB00287C

The association between preeclampsia and the severity of gestational diabetes: The impact of glycemic control
journal, November 2004

  • Yogev, Yariv; Xenakis, Elly M. J.; Langer, Oded
  • American Journal of Obstetrics and Gynecology, Vol. 191, Issue 5
  • DOI: 10.1016/j.ajog.2004.03.074

Fraction of Gestational Diabetes Mellitus Attributable to Overweight and Obesity by Race/Ethnicity, California, 2007–2009
journal, October 2013

  • Kim, Shin Y.; Saraiva, Carina; Curtis, Michael
  • American Journal of Public Health, Vol. 103, Issue 10
  • DOI: 10.2105/AJPH.2013.301469

Lipopolysaccharide-Binding Protein as Marker of Fetal Inflammatory Response Syndrome after Preterm Premature Rupture of Membranes
journal, December 2013

  • Pavcnik-Arnol, Maja; Lucovnik, Miha; Kornhauser-Cerar, Lilijana
  • Neonatology, Vol. 105, Issue 2
  • DOI: 10.1159/000356735

Immunohistochemical expression of Annexin A5 in preeclamptic placentas☆
journal, March 2011


The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
journal, July 2017


Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses
journal, January 2008

  • Livesay, Eric A.; Tang, Keqi; Taylor, Beverley K.
  • Analytical Chemistry, Vol. 80, Issue 1
  • DOI: 10.1021/ac701727r

Defective Fatty Acid Uptake in the Spontaneously Hypertensive Rat Is a Primary Determinant of Altered Glucose Metabolism, Hyperinsulinemia, and Myocardial Hypertrophy
journal, April 2001

  • Hajri, Tahar; Ibrahimi, Azeddine; Coburn, Chris T.
  • Journal of Biological Chemistry, Vol. 276, Issue 26
  • DOI: 10.1074/jbc.M100942200

A short history of inositol lipids
journal, September 2016


Short- and medium-chain fatty acids in energy metabolism: the cellular perspective
journal, April 2016

  • Schönfeld, Peter; Wojtczak, Lech
  • Journal of Lipid Research, Vol. 57, Issue 6
  • DOI: 10.1194/jlr.R067629

Cheminformatics approach to exploring and modeling trait-associated metabolite profiles
journal, June 2019

  • Ash, Jeremy R.; Kuenemann, Melaine A.; Rotroff, Daniel
  • Journal of Cheminformatics, Vol. 11, Issue 1
  • DOI: 10.1186/s13321-019-0366-3

A Multiple Comparison Procedure for Comparing Several Treatments with a Control
journal, December 1955


MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses
journal, May 2016


Variation in lipid levels during pregnancy in women with different types of hypertension
journal, January 1996

  • Gratacós, Eduard; Casals, Elena; Sanllehy, Carolina
  • Acta Obstetricia et Gynecologica Scandinavica, Vol. 75, Issue 10
  • DOI: 10.3109/00016349609055024

Postpartum glucose intolerance: an updated overview
journal, August 2017


Placental glycolysis and energy metabolism in preeclampsia
journal, July 1987

  • Bloxam, David L.; Bullen, Bridget E.; Walters, Barry N. J.
  • American Journal of Obstetrics and Gynecology, Vol. 157, Issue 1
  • DOI: 10.1016/S0002-9378(87)80354-X

Integrated Proteomic and Metabolomic prediction of Term Preeclampsia
journal, November 2017


Effects of obesity and gestational diabetes mellitus on placental phospholipids
journal, August 2015

  • Uhl, Olaf; Demmelmair, Hans; Segura, María Teresa
  • Diabetes Research and Clinical Practice, Vol. 109, Issue 2
  • DOI: 10.1016/j.diabres.2015.05.032

DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein?
journal, January 2017


Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses
journal, December 2017


SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules
journal, February 1988

  • Weininger, David
  • Journal of Chemical Information and Modeling, Vol. 28, Issue 1
  • DOI: 10.1021/ci00057a005

Racial/Ethnic Differences in Dyslipidemia Patterns
journal, February 2014


Improved quality control processing of peptide-centric LC-MS proteomics data
journal, August 2011


Placental Cytokines and the Pathogenesis of Preeclampsia
journal, March 1997


Bayesian Proteoform Modeling Improves Protein Quantification of Global Proteomic Measurements
journal, November 2014

  • Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Datta, Susmita
  • Molecular & Cellular Proteomics, Vol. 13, Issue 12
  • DOI: 10.1074/mcp.M113.030932

A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues
journal, May 1957


Generation and validation of a universal perinatal database and biospecimen repository: PeriBank
journal, September 2016

  • Antony, K. M.; Hemarajata, P.; Chen, J.
  • Journal of Perinatology, Vol. 36, Issue 11
  • DOI: 10.1038/jp.2016.130

Detecting Differential and Correlated Protein Expression in Label-Free Shotgun Proteomics
journal, November 2006

  • Zhang, Bing; VerBerkmoes, Nathan C.; Langston, Michael A.
  • Journal of Proteome Research, Vol. 5, Issue 11
  • DOI: 10.1021/pr0600273

The Pathophysiology of Gestational Diabetes Mellitus
journal, October 2018

  • Plows, Jasmine; Stanley, Joanna; Baker, Philip
  • International Journal of Molecular Sciences, Vol. 19, Issue 11
  • DOI: 10.3390/ijms19113342

Changes in Fatty Acid Composition of Cervical Mucus Lecithin during Pregnancy
journal, January 1989

  • Pschera, Helmut; Larsson, Bertil; Kjaeldgaard, Anders
  • Gynecologic and Obstetric Investigation, Vol. 28, Issue 3
  • DOI: 10.1159/000293545

Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis
journal, November 2007


Plasmalogen metabolism-related enzymes in rat brain during aging: influence of n-3 fatty acid intake
journal, January 2006