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Title: Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution

Abstract

Abstract Closely related muntjac deer show striking karyotype differences. Here we describe chromosome-scale genome assemblies for Chinese and Indian muntjacs, Muntiacus reevesi (2 n  = 46) and Muntiacus muntjak vaginalis (2 n  = 6/7), and analyze their evolution and architecture. The genomes show extensive collinearity with each other and with other deer and cattle. We identified numerous fusion events unique to and shared by muntjacs relative to the cervid ancestor, confirming many cytogenetic observations with genome sequence. One of these M. muntjak fusions reversed an earlier fission in the cervid lineage. Comparative Hi-C analysis showed that the chromosome fusions on the M. muntjak lineage altered long-range, three-dimensional chromosome organization relative to M. reevesi in interphase nuclei including A/B compartment structure. This reshaping of multi-megabase contacts occurred without notable change in local chromatin compaction, even near fusion sites. A few genes involved in chromosome maintenance show evidence for rapid evolution, possibly associated with the dramatic changes in karyotype.

Authors:
ORCiD logo; ORCiD logo; ; ORCiD logo; ORCiD logo
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1657263
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Published Article
Journal Name:
Communications Biology
Additional Journal Information:
Journal Name: Communications Biology Journal Volume: 3 Journal Issue: 1; Journal ID: ISSN 2399-3642
Publisher:
Nature Publishing Group
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Mudd, Austin B., Bredeson, Jessen V., Baum, Rachel, Hockemeyer, Dirk, and Rokhsar, Daniel S.. Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution. United Kingdom: N. p., 2020. Web. https://doi.org/10.1038/s42003-020-1096-9.
Mudd, Austin B., Bredeson, Jessen V., Baum, Rachel, Hockemeyer, Dirk, & Rokhsar, Daniel S.. Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution. United Kingdom. https://doi.org/10.1038/s42003-020-1096-9
Mudd, Austin B., Bredeson, Jessen V., Baum, Rachel, Hockemeyer, Dirk, and Rokhsar, Daniel S.. Tue . "Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution". United Kingdom. https://doi.org/10.1038/s42003-020-1096-9.
@article{osti_1657263,
title = {Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution},
author = {Mudd, Austin B. and Bredeson, Jessen V. and Baum, Rachel and Hockemeyer, Dirk and Rokhsar, Daniel S.},
abstractNote = {Abstract Closely related muntjac deer show striking karyotype differences. Here we describe chromosome-scale genome assemblies for Chinese and Indian muntjacs, Muntiacus reevesi (2 n  = 46) and Muntiacus muntjak vaginalis (2 n  = 6/7), and analyze their evolution and architecture. The genomes show extensive collinearity with each other and with other deer and cattle. We identified numerous fusion events unique to and shared by muntjacs relative to the cervid ancestor, confirming many cytogenetic observations with genome sequence. One of these M. muntjak fusions reversed an earlier fission in the cervid lineage. Comparative Hi-C analysis showed that the chromosome fusions on the M. muntjak lineage altered long-range, three-dimensional chromosome organization relative to M. reevesi in interphase nuclei including A/B compartment structure. This reshaping of multi-megabase contacts occurred without notable change in local chromatin compaction, even near fusion sites. A few genes involved in chromosome maintenance show evidence for rapid evolution, possibly associated with the dramatic changes in karyotype.},
doi = {10.1038/s42003-020-1096-9},
journal = {Communications Biology},
number = 1,
volume = 3,
place = {United Kingdom},
year = {2020},
month = {9}
}

Journal Article:
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https://doi.org/10.1038/s42003-020-1096-9

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