Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio

Callaway, Connor P.; Bond, Nicholas; Hendrickson, Kayla; Lee, Seung Min; Jang, Seung Soon

doi:10.1021/acs.jpcb.8b07769

Title: Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio

Journal Article · 14 November 2018 · Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry

DOI: https://doi.org/10.1021/acs.jpcb.8b07769 · OSTI ID:1657067

Callaway, Connor P. ^[1]; Bond, Nicholas ^[2]; Hendrickson, Kayla ^[2]; Lee, Seung Min ^[2];

^[2]

Georgia Inst. of Technology, Atlanta, GA (United States); Georgia Tech, Atlanta, GA, US
Georgia Inst. of Technology, Atlanta, GA (United States)

Structural variation in multicompartment micelles consisting of lipophilic–hydrophilic–fluorophilic (hereafter referred to as BAC) triblock copolymers is investigated using the dissipative particle dynamics simulation method. It is demonstrated from our results that the structure of BAC multicompartment micelles is effectively tuned as a function of the lipophilic–fluorophilic ratio parameter, here termed $$R_1$$, of the constituent linear triblock copolymers. In particular, a morphological deviation from onion-like ABC micelles arises in BAC micelle systems as $$R_1$$ increases. The morphologies of BAC micelles with $$R_1\ll$$1 or $$R_1\gg$$1 display striking similarities, with the only notable difference being an inversion of the lipophilic and fluorophilic regions. When $$R\approx$$ 1, segmented worm-like structures with multiple cores are favored in BAC micelle systems. Through this study, it is confirmed that the block length ratio is an effective control parameter to tune the structure of multicompartment micelles.

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Research Organization:: Georgia Inst. of Technology, Atlanta, GA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-03ER15459

OSTI ID:: 1657067

Journal Information:: Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry, Journal Name: Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry Journal Issue: 50 Vol. 122; ISSN 1520-6106

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Structural Tunability of Multicompartment Micelles as a Function of Lipophilic–Fluorophilic Block Length Ratio

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