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Title: Divergent Members of the Nitrogenase Superfamily: Tetrapyrrole Biosynthesis and Beyond

Abstract

The nitrogenase superfamily constitutes a large and diverse ensemble of two–component metalloenzymes. These systems couple the hydrolysis of ATP to the reduction of disparate substrates from diatomic gases (Mo and alternative nitrogenases) to photosynthetic pigments (protochlorophyllide and chlorophyllide oxidoreductases). Only very recently have the activities of the highly divergent and paraphyletic Group IV nitrogenases begun to be uncovered. In conclusion, this review highlights the first characterized member of this group, which was found to catalyze an unprecedented reaction in the coenzyme F430 biosynthetic pathway, and the catalytic potential of a superfamily that has yet to be fully explored.

Authors:
 [1]; ORCiD logo [1]
  1. Auburn University, AL (United States)
Publication Date:
Research Org.:
Auburn Univ., AL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1656752
Alternate Identifier(s):
OSTI ID: 1633690
Grant/Contract Number:  
SC0018043
Resource Type:
Accepted Manuscript
Journal Name:
ChemBioChem: a European journal of chemical biology
Additional Journal Information:
Journal Volume: 21; Journal Issue: 12; Journal ID: ISSN 1439-4227
Publisher:
ChemPubSoc Europe
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Ghebreamlak, Selamawit M., and Mansoorabadi, Steven O.. Divergent Members of the Nitrogenase Superfamily: Tetrapyrrole Biosynthesis and Beyond. United States: N. p., 2020. Web. https://doi.org/10.1002/cbic.201900782.
Ghebreamlak, Selamawit M., & Mansoorabadi, Steven O.. Divergent Members of the Nitrogenase Superfamily: Tetrapyrrole Biosynthesis and Beyond. United States. https://doi.org/10.1002/cbic.201900782
Ghebreamlak, Selamawit M., and Mansoorabadi, Steven O.. Mon . "Divergent Members of the Nitrogenase Superfamily: Tetrapyrrole Biosynthesis and Beyond". United States. https://doi.org/10.1002/cbic.201900782. https://www.osti.gov/servlets/purl/1656752.
@article{osti_1656752,
title = {Divergent Members of the Nitrogenase Superfamily: Tetrapyrrole Biosynthesis and Beyond},
author = {Ghebreamlak, Selamawit M. and Mansoorabadi, Steven O.},
abstractNote = {The nitrogenase superfamily constitutes a large and diverse ensemble of two–component metalloenzymes. These systems couple the hydrolysis of ATP to the reduction of disparate substrates from diatomic gases (Mo and alternative nitrogenases) to photosynthetic pigments (protochlorophyllide and chlorophyllide oxidoreductases). Only very recently have the activities of the highly divergent and paraphyletic Group IV nitrogenases begun to be uncovered. In conclusion, this review highlights the first characterized member of this group, which was found to catalyze an unprecedented reaction in the coenzyme F430 biosynthetic pathway, and the catalytic potential of a superfamily that has yet to be fully explored.},
doi = {10.1002/cbic.201900782},
journal = {ChemBioChem: a European journal of chemical biology},
number = 12,
volume = 21,
place = {United States},
year = {2020},
month = {3}
}

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