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Title: Megahertz single-particle imaging at the European XFEL

Abstract

© 2020, The Author(s). The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

Authors:
ORCiD logo [1];  [2];  [3];  [3];  [4];  [4];  [5]; ORCiD logo [6]; ORCiD logo [7];  [8];  [9];  [3]; ORCiD logo [2]; ORCiD logo [10];  [1]; ORCiD logo [11];  [3]; ORCiD logo [4];  [12]; ORCiD logo [13] more »; ORCiD logo [8];  [3];  [14]; ORCiD logo [15];  [16];  [2];  [17];  [3];  [3];  [14]; ORCiD logo [3];  [5]; ORCiD logo [10]; ORCiD logo [3];  [18];  [3];  [19];  [4];  [16];  [3];  [20]; ORCiD logo [8];  [3];  [3]; ORCiD logo [3];  [16]; ORCiD logo [21];  [3];  [3];  [17];  [14];  [3];  [3];  [2];  [22];  [23]; ORCiD logo [24];  [3];  [25]; ORCiD logo [6];  [3]; ORCiD logo [26];  [1];  [3]; ORCiD logo [27] « less
+ Show Author Affiliations
  1. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). European Molecular Biology Lab. (EMBL)
  2. National Research Centre, Moscow (Russia). Kurchatov Institute
  3. European XFEL GmbH, Schenefeld (Germany)
  4. Uppsala Univ. (Sweden). Lab. of Molecular Biophysics
  5. Academy of Sciences of the Czech Republic, Prague (Czech Republic)
  6. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Max Planck Inst. for the Structure and Dynamics of Matter, Heidelberg (Germany)
  7. Slovak Academy of Science (SAS), Bratislava (Slovakia)
  8. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)
  9. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science
  10. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Univ. of Hamburg (Germany). Hamburg Center for Ultrafast Imaging; Univ. of Hamburg (Germany)
  11. Uppsala Univ. (Sweden). Lab. of Molecular Biophysics; National Univ. of Singapore. Center for BioImaging Sciences
  12. La Trobe Univ., Melbourne, VIC (Australia). ARC CEnter of Advanced Molecular Imaging
  13. Russian Academy of Sciences, Moscow (Russia). Lab. of Bioinformatics and Proteomics; Russian Academy of Sciences, Moscow (Russia). Inst. of Theoretical and Experimental Biophysics
  14. Arizona State Univ., Tempe, AZ (United States)
  15. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Univ. of Hamburg (Germany). Hamburg Center for Ultrafast Imaging
  16. Univ. of Wisconsin, Milwaukee, WI (United States)
  17. Pohang Univ. of Science and Technology (South Korea)
  18. National Univ. of Singapore, Center for BioImaging Sciences
  19. Arizona State Univ., Tempe, AZ (United States). Biodesign Inst.
  20. Australian National Univ., Canberra, ACT (Australia). Laser Physics Center
  21. KTH Royal Inst. of Technology, Stockholm (Sweden). AlbaNova Univ. Center
  22. Uppsala Univ. (Sweden)
  23. State Univ. of New York (SUNY), Buffalo, NY (United States)
  24. European XFEL GmbH, Schenefeld (Germany); Heinrich Pette Inst., Hamburg (Germany). Leibniz Inst. for Experimental Virology
  25. Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
  26. Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); National Research Nuclear Univ., MEPhI, Moscow (Russia)
  27. Uppsala Univ. (Sweden). Lab. of Molecular Biophysics; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Research Foundation of Korea (NRF); Russian Science Foundation; German Ministry for Education and Research (BMBF)
OSTI Identifier:
1649993
Alternate Identifier(s):
OSTI ID: 1661614
Report Number(s):
BNL-216277-2020-JAAM
Journal ID: ISSN 2399-3650
Grant/Contract Number:  
SC0012704; HRSF-0002/18-41-0600; 18-14-00321; NRF-CRP16-2015-05; NSF 1231306; 05K2016; 2017K1A3A7A09016380; AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Communications Physics
Additional Journal Information:
Journal Volume: 3; Journal Issue: 1; Journal ID: ISSN 2399-3650
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; Free-electron lasers; Imaging techniques; Nanoscale biophysics; X-rays

Citation Formats

Sobolev, Egor, Zolotarev, Sergei, Giewekemeyer, Klaus, Bielecki, Johan, Okamoto, Kenta, Reddy, Hemanth N., Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N., Chojnowski, Grzegorz, Daurer, Benedikt J., Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonie, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G., Horke, Daniel A., Hosseinizadeh, Ahmad, Ilyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A., Kirkwood, Henry, Kulyk, Olena, Küpper, Jochen, Letrun, Romain, Loh, N. Duane, Lorenzen, Kristina, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V., Rose, Max, Round, Adam, Sato, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John H., Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Uetrecht, Charlotte, Weinhausen, Britta, Williams, Garth J., Xavier, P. Lourdu, Xu, Chen, Vartanyants, Ivan A., Lamzin, Victor S., Mancuso, Adrian, and Maia, Filipe C. Megahertz single-particle imaging at the European XFEL. United States: N. p., 2020. Web. doi:10.1038/s42005-020-0362-y.
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Sobolev, Egor, Zolotarev, Sergei, Giewekemeyer, Klaus, Bielecki, Johan, Okamoto, Kenta, Reddy, Hemanth N., Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N., Chojnowski, Grzegorz, Daurer, Benedikt J., Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonie, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G., Horke, Daniel A., Hosseinizadeh, Ahmad, Ilyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A., Kirkwood, Henry, Kulyk, Olena, Küpper, Jochen, Letrun, Romain, Loh, N. Duane, Lorenzen, Kristina, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V., Rose, Max, Round, Adam, Sato, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John H., Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Uetrecht, Charlotte, Weinhausen, Britta, Williams, Garth J., Xavier, P. Lourdu, Xu, Chen, Vartanyants, Ivan A., Lamzin, Victor S., Mancuso, Adrian, & Maia, Filipe C. Megahertz single-particle imaging at the European XFEL. United States. https://doi.org/10.1038/s42005-020-0362-y
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Sobolev, Egor, Zolotarev, Sergei, Giewekemeyer, Klaus, Bielecki, Johan, Okamoto, Kenta, Reddy, Hemanth N., Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N., Chojnowski, Grzegorz, Daurer, Benedikt J., Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonie, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G., Horke, Daniel A., Hosseinizadeh, Ahmad, Ilyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A., Kirkwood, Henry, Kulyk, Olena, Küpper, Jochen, Letrun, Romain, Loh, N. Duane, Lorenzen, Kristina, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V., Rose, Max, Round, Adam, Sato, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John H., Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Uetrecht, Charlotte, Weinhausen, Britta, Williams, Garth J., Xavier, P. Lourdu, Xu, Chen, Vartanyants, Ivan A., Lamzin, Victor S., Mancuso, Adrian, and Maia, Filipe C. Fri . "Megahertz single-particle imaging at the European XFEL". United States. https://doi.org/10.1038/s42005-020-0362-y. https://www.osti.gov/servlets/purl/1649993.
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@article{osti_1649993,
title = {Megahertz single-particle imaging at the European XFEL},
author = {Sobolev, Egor and Zolotarev, Sergei and Giewekemeyer, Klaus and Bielecki, Johan and Okamoto, Kenta and Reddy, Hemanth N. and Andreasson, Jakob and Ayyer, Kartik and Barak, Imrich and Bari, Sadia and Barty, Anton and Bean, Richard and Bobkov, Sergey and Chapman, Henry N. and Chojnowski, Grzegorz and Daurer, Benedikt J. and Dörner, Katerina and Ekeberg, Tomas and Flückiger, Leonie and Galzitskaya, Oxana and Gelisio, Luca and Hauf, Steffen and Hogue, Brenda G. and Horke, Daniel A. and Hosseinizadeh, Ahmad and Ilyin, Vyacheslav and Jung, Chulho and Kim, Chan and Kim, Yoonhee and Kirian, Richard A. and Kirkwood, Henry and Kulyk, Olena and Küpper, Jochen and Letrun, Romain and Loh, N. Duane and Lorenzen, Kristina and Messerschmidt, Marc and Mühlig, Kerstin and Ourmazd, Abbas and Raab, Natascha and Rode, Andrei V. and Rose, Max and Round, Adam and Sato, Takushi and Schubert, Robin and Schwander, Peter and Sellberg, Jonas A. and Sikorski, Marcin and Silenzi, Alessandro and Song, Changyong and Spence, John H. and Stern, Stephan and Sztuk-Dambietz, Jolanta and Teslyuk, Anthon and Timneanu, Nicusor and Trebbin, Martin and Uetrecht, Charlotte and Weinhausen, Britta and Williams, Garth J. and Xavier, P. Lourdu and Xu, Chen and Vartanyants, Ivan A. and Lamzin, Victor S. and Mancuso, Adrian and Maia, Filipe C.},
abstractNote = {© 2020, The Author(s). The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.},
doi = {10.1038/s42005-020-0362-y},
journal = {Communications Physics},
number = 1,
volume = 3,
place = {United States},
year = {Fri May 29 00:00:00 EDT 2020},
month = {Fri May 29 00:00:00 EDT 2020}
}
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