Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures

Tolba, Samar A.; Magnuson, Andrew D.; Sun, Tao; Lei, Xin Gen

doi:10.1016/j.psj.2020.05.022

Title: Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures

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Abstract

This research was to determine effects of supplemental dietary microalgal astaxanthin (AST) on hepatic gene expression and protein production of redox enzymes, heat shock proteins (HSPs), cytokines, and lipid metabolism in broilers (BR) and laying hens (LH) under high ambient temperatures. A total of 240 (day old) Cornish male BR and 50 (19 wk old) White Leghorn Shavers LH were allotted in 5 dietary treatments with 6 and 10 cages/treatment (8 BR or 1 LH/cage), respectively. The birds were fed corn-soybean meal basal diets supplemented with microalgal (Haematococcus pluvialis) AST at 0, 10, 20, 40, and 80 mg/kg diet for 6 wk. Supplemental AST to the BR diet linearly decreased (P < 0.10, R² 5 0.18–0.36) hepatic mRNA levels of several redox status-controlling genes, heat shock protein 70 (HSP70), heat shock transcription factor 1 (HSTF1), c-Jun N-terminal kinase 1 (JNK1), tumor necrosis factor-a, and sterol regulatory element-binding protein 1 (SREBP1). The supplementation linearly elevated (P = 0.04, R2 = 0.20) diacylglycerol acyltransferase 2 (DGAT2) mRNA level and produced quadratic changes (P < 0.10, R² 5 0.15–0.47) in mRNA levels of glutathione S-transferase (GST), serine/threonine kinase (AKT1), P38 mitogen-activated protein kinase (P38MAKP), lipid metabolism–controlling genes, and the protein production of HSP90more »« less

Authors:: Tolba, Samar A.; Magnuson, Andrew D.; Sun, Tao; Lei, Xin Gen

Publication Date:: Thu Oct 01 00:00:00 EDT 2020

Research Org.:: Duke Univ., Durham, NC (United States)

Sponsoring Org.:: USDOE Office of Energy Efficiency and Renewable Energy (EERE)

OSTI Identifier:: 1647250

Alternate Identifier(s):: OSTI ID: 1848482

Grant/Contract Number:: EE0007091

Resource Type:: Published Article

Journal Name:: Poultry Science

Additional Journal Information:: Journal Name: Poultry Science Journal Volume: 99 Journal Issue: 10; Journal ID: ISSN 0032-5791

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; agriculture; astaxanthin; gene; poultry; redox status

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                    Tolba, Samar A., Magnuson, Andrew D., Sun, Tao, and Lei, Xin Gen. Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures.  United States: N. p., 2020. 
Web.  doi:10.1016/j.psj.2020.05.022.

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                    Tolba, Samar A., Magnuson, Andrew D., Sun, Tao, & Lei, Xin Gen. Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures.  United States.  https://doi.org/10.1016/j.psj.2020.05.022

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                    Tolba, Samar A., Magnuson, Andrew D., Sun, Tao, and Lei, Xin Gen. Thu .  
"Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures".  United States.  https://doi.org/10.1016/j.psj.2020.05.022.

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@article{osti_1647250,

  title        = {Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures},

  author       = {Tolba, Samar A. and Magnuson, Andrew D. and Sun, Tao and Lei, Xin Gen},

  abstractNote = {This research was to determine effects of supplemental dietary microalgal astaxanthin (AST) on hepatic gene expression and protein production of redox enzymes, heat shock proteins (HSPs), cytokines, and lipid metabolism in broilers (BR) and laying hens (LH) under high ambient temperatures. A total of 240 (day old) Cornish male BR and 50 (19 wk old) White Leghorn Shavers LH were allotted in 5 dietary treatments with 6 and 10 cages/treatment (8 BR or 1 LH/cage), respectively. The birds were fed corn-soybean meal basal diets supplemented with microalgal (Haematococcus pluvialis) AST at 0, 10, 20, 40, and 80 mg/kg diet for 6 wk. Supplemental AST to the BR diet linearly decreased (P < 0.10, R2 5 0.18–0.36) hepatic mRNA levels of several redox status-controlling genes, heat shock protein 70 (HSP70), heat shock transcription factor 1 (HSTF1), c-Jun N-terminal kinase 1 (JNK1), tumor necrosis factor-a, and sterol regulatory element-binding protein 1 (SREBP1). The supplementation linearly elevated (P = 0.04, R2 = 0.20) diacylglycerol acyltransferase 2 (DGAT2) mRNA level and produced quadratic changes (P < 0.10, R2 5 0.15–0.47) in mRNA levels of glutathione S-transferase (GST), serine/threonine kinase (AKT1), P38 mitogen-activated protein kinase (P38MAKP), lipid metabolism–controlling genes, and the protein production of HSP90 and P38MAPK in the liver. Supplementing AST to the LH diets linearly decreased (P < 0.10, R2 5 0.18–0.56) mRNA levels of GST, HSF1, JNK1, and interleukin 10; lipogenesis genes; and JNK1 protein production. However, supplemental dietary AST produced quadratic changes (P < 0.10, R2 5 0.26–0.72) in mRNA levels of most antioxidant-, stress-responsive, and lipid metabolism–related genes in the liver of LH. In conclusion, supplemental dietary AST affected the hepatic gene expression and protein production related to redox status, heat stress and inflammation, and lipid metabolism in both BR and LH. The impacts varied with the chicken type and demonstrated linear and quadratic regressions with the inclusion levels of AST.},

  doi          = {10.1016/j.psj.2020.05.022},

  journal      = {Poultry Science},

  number       = 10,

  volume       = 99,

  place        = {United States},

  year         = {Thu Oct 01 00:00:00 EDT 2020},

  month        = {Thu Oct 01 00:00:00 EDT 2020}

}

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