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Title: FLASH radiotherapy: ultra-high dose rates to spare healthy tissue

Abstract

A recent addition to the treatment options in external beam therapy, so-called FLASH radiotherapy, shows remarkable healthy-tissue-sparing properties in a number of pre-clinical studies without impacting the overall treatment efficacy. Its potential in clinical applications is attracting a great deal of interest in the medical community. The use of ultra-high dose rates at extremely short irradiation times has been shown to significantly enhance the differential effects between normal and tumor tissue. This makes it possible to increase treatment doses without further harming the surrounding healthy tissue. While most studies to date have focused on the use of electron beams, X-ray and proton FLASH radiotherapy have also shown beneficial effects, although for these latter two the results still need to be independently confirmed. Additionally, the mechanisms underlying the biological effects remain to be elucidated. Very recently, the FLASH effect has been demonstrated in the first human patient, with promising results, supporting further clinical studies. In this work, we present an overview of the investigations into FLASH radiotherapy to date.

Authors:
ORCiD logo [1]
  1. Delft Univ. of Technology (Netherlands); Argonne National Lab. (ANL), Argonne, IL (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC)
OSTI Identifier:
1645018
Grant/Contract Number:  
AC02-06CH11357; 2019-0296
Resource Type:
Accepted Manuscript
Journal Name:
International Journal of Radiation Biology
Additional Journal Information:
Journal Volume: 96; Journal Issue: 4; Journal ID: ISSN 0955-3002
Publisher:
Taylor and Francis
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FLASH-RT; normal tissue protection; ultra-high dose-rate irradiation; differential effect

Citation Formats

de Kruijff, R. M.. FLASH radiotherapy: ultra-high dose rates to spare healthy tissue. United States: N. p., 2019. Web. https://doi.org/10.1080/09553002.2020.1704912.
de Kruijff, R. M.. FLASH radiotherapy: ultra-high dose rates to spare healthy tissue. United States. https://doi.org/10.1080/09553002.2020.1704912
de Kruijff, R. M.. Thu . "FLASH radiotherapy: ultra-high dose rates to spare healthy tissue". United States. https://doi.org/10.1080/09553002.2020.1704912. https://www.osti.gov/servlets/purl/1645018.
@article{osti_1645018,
title = {FLASH radiotherapy: ultra-high dose rates to spare healthy tissue},
author = {de Kruijff, R. M.},
abstractNote = {A recent addition to the treatment options in external beam therapy, so-called FLASH radiotherapy, shows remarkable healthy-tissue-sparing properties in a number of pre-clinical studies without impacting the overall treatment efficacy. Its potential in clinical applications is attracting a great deal of interest in the medical community. The use of ultra-high dose rates at extremely short irradiation times has been shown to significantly enhance the differential effects between normal and tumor tissue. This makes it possible to increase treatment doses without further harming the surrounding healthy tissue. While most studies to date have focused on the use of electron beams, X-ray and proton FLASH radiotherapy have also shown beneficial effects, although for these latter two the results still need to be independently confirmed. Additionally, the mechanisms underlying the biological effects remain to be elucidated. Very recently, the FLASH effect has been demonstrated in the first human patient, with promising results, supporting further clinical studies. In this work, we present an overview of the investigations into FLASH radiotherapy to date.},
doi = {10.1080/09553002.2020.1704912},
journal = {International Journal of Radiation Biology},
number = 4,
volume = 96,
place = {United States},
year = {2019},
month = {12}
}

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Works referenced in this record:

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