Design and Testing of Vector-Producing HEK293T Cells Bearing a Genomic Deletion of the SV40 T Antigen Coding Region

Bae, Dahae Hailey; Marino, Michael; Iaffaldano, Brian; Fenstermaker, Sydney; Afione, Sandra; Argaw, Takele; McCright, Jacob; Kwilas, Anna; Chiorini, John A.; Timmons, Andrew E.; Reiser, Jakob

doi:10.1016/j.omtm.2020.07.006

Title: Design and Testing of Vector-Producing HEK293T Cells Bearing a Genomic Deletion of the SV40 T Antigen Coding Region

Journal Article · 31 August 2020 · Molecular Therapy. Methods & Clinical Development

DOI: https://doi.org/10.1016/j.omtm.2020.07.006 · OSTI ID:1644328

Bae, Dahae Hailey; Marino, Michael; Iaffaldano, Brian; Fenstermaker, Sydney; Afione, Sandra; Argaw, Takele; McCright, Jacob; Kwilas, Anna; Chiorini, John A.; Timmons, Andrew E.; Reiser, Jakob

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Sponsoring Organization:: USDOE

OSTI ID:: 1644328

Journal Information:: Molecular Therapy. Methods & Clinical Development, Journal Name: Molecular Therapy. Methods & Clinical Development Journal Issue: C Vol. 18; ISSN 2329-0501

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations Lin, Yao-Cheng; Boone, Morgane; Meuris, Leander Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5767	journal	September 2014
Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors Kutner, Robert H.; Zhang, Xian-Yang; Reiser, Jakob Nature Protocols, Vol. 4, Issue 4 https://doi.org/10.1038/nprot.2009.22	journal	March 2009
Specific Targeting of Human Interleukin (IL)-13 Receptor α2-Positive Cells with Lentiviral Vectors Displaying IL-13 Ou, Wu; Marino, Michael P.; Suzuki, Akiko Human Gene Therapy Methods, Vol. 23, Issue 2 https://doi.org/10.1089/hgtb.2012.054	journal	April 2012
Efficiency and Specificity of Targeted Integration Mediated by the Adeno-Associated Virus Serotype 2 Rep 78 Protein Li, Pingjuan; Marino, Michael P.; Zou, Jizhong Human Gene Therapy Methods, Vol. 29, Issue 3 https://doi.org/10.1089/hgtb.2018.052	journal	June 2018
Large-Scale Manufacture and Characterization of a Lentiviral Vector Produced for ClinicalEx VivoGene Therapy Application Merten, Otto-Wilhelm; Charrier, Sabine; Laroudie, Nicolas Human Gene Therapy, Vol. 22, Issue 3 https://doi.org/10.1089/hum.2010.060	journal	March 2011
Lentivirus Production Is Influenced by SV40 Large T-Antigen and Chromosomal Integration of the Vector in HEK293 Cells Gama-Norton, Leonor; Botezatu, Lacramioara; Herrmann, Sabrina Human Gene Therapy, Vol. 22, Issue 10 https://doi.org/10.1089/hum.2010.143	journal	October 2011
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Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 Russell, W. C.; Graham, F. L.; Smiley, J. Journal of General Virology, Vol. 36, Issue 1 https://doi.org/10.1099/0022-1317-36-1-59	journal	July 1977
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Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells Heinzel, S. S.; Krysan, P. J.; Calos, M. P. Journal of Virology, Vol. 62, Issue 10 https://doi.org/10.1128/jvi.62.10.3738-3746.1988	journal	October 1988
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