COST1 regulates autophagy to control plant drought tolerance

Bao, Yan; Song, Wei-Meng; Wang, Peipei; Yu, Xiang; Li, Bei; Jiang, Chunmei; Shiu, Shin-Han; Zhang, Hongxia; Bassham, Diane C.

doi:10.1073/pnas.1918539117

Title: COST1 regulates autophagy to control plant drought tolerance

Journal Article · 13 March 2020 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.1918539117 · OSTI ID:1637442

^[1]; Song, Wei-Meng ^[2]; Wang, Peipei ^[3]; Yu, Xiang ^[4]; Li, Bei ^[5]; Jiang, Chunmei ^[5];

^[3]; Zhang, Hongxia ^[2]; Bassham, Diane C. ^[6]

Iowa State Univ., Ames, IA (United States); Chinese Academy of Sciences, Shanghai (China); Michigan State Univ., East Lansing, MI (United States)
Chinese Academy of Sciences, Shanghai (China); Ludong Univ., Yantai (China)
Michigan State Univ., East Lansing, MI (United States)
Chinese Academy of Sciences, Shanghai (China)
Ludong Univ., Yantai (China)
Iowa State Univ., Ames, IA (United States)

Plants balance their competing requirements for growth and stress tolerance via a sophisticated regulatory circuitry that controls responses to the external environments. We have identified a plant-specific gene, COST1 (constitutively stressed 1), that is required for normal plant growth but negatively regulates drought resistance by influencing the autophagy pathway. An Arabidopsis thaliana cost1 mutant has decreased growth and increased drought tolerance, together with constitutive autophagy and increased expression of drought-response genes, while overexpression of COST1 confers drought hypersensitivity and reduced autophagy. The COST1 protein is degraded upon plant dehydration, and this degradation is reduced upon treatment with inhibitors of the 26S proteasome or autophagy pathways. The drought resistance of a cost1 mutant is dependent on an active autophagy pathway, but independent of other known drought signaling pathways, indicating that COST1 acts through regulation of autophagy. In addition, COST1 colocalizes to autophagosomes with the autophagosome marker ATG8e and the autophagy adaptor NBR1, and affects the level of ATG8e protein through physical interaction with ATG8e, indicating a pivotal role in direct regulation of autophagy. We propose a model in which COST1 represses autophagy under optimal conditions, thus allowing plant growth. Under drought, COST1 is degraded, enabling activation of autophagy and suppression of growth to enhance drought tolerance. Our research places COST1 as an important regulator controlling the balance between growth and stress responses via the direct regulation of autophagy.

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Research Organization:: Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018409

OSTI ID:: 1637442

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 13; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
autophagy
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COST1

Title: COST1 regulates autophagy to control plant drought tolerance

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