Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors

Liu, Renshuai; Liu, Lulu; Yang, Xinying; Fang, Hao

doi:10.1016/j.bioorg.2019.102938

Title: Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors

Journal Article · 01 July 2019 · Bioorganic Chemistry

DOI: https://doi.org/10.1016/j.bioorg.2019.102938 · OSTI ID:1636105

Liu, Renshuai; Liu, Lulu; Yang, Xinying; Fang, Hao

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

Grant/Contract Number:: 2017CXGC1401

OSTI ID:: 1636105

Journal Information:: Bioorganic Chemistry, Journal Name: Bioorganic Chemistry Vol. 88 Journal Issue: C; ISSN 0045-2068

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 10 works

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References (17)

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Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules: Miniperspective Yap, Jeremy L.; Chen, Lijia; Lanning, Maryanna E. Journal of Medicinal Chemistry, Vol. 60, Issue 3 https://doi.org/10.1021/acs.jmedchem.5b01888	journal	December 2016
Pharmacokinetics of Venetoclax, a Novel BCL-2 Inhibitor, in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Non-Hodgkin Lymphoma: Journal of Clinical Pharmacology Salem, Ahmed Hamed; Agarwal, Suresh K.; Dunbar, Martin The Journal of Clinical Pharmacology, Vol. 57, Issue 4 https://doi.org/10.1002/jcph.821	journal	November 2016
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors Wan, Yichao; Wang, Junhua; Sun, Feng’e Bioorganic & Medicinal Chemistry, Vol. 23, Issue 24 https://doi.org/10.1016/j.bmc.2015.11.014	journal	December 2015
Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains Wan, Yichao; Liu, Tingting; Li, Xiaoxian Bioorganic & Medicinal Chemistry, Vol. 25, Issue 1 https://doi.org/10.1016/j.bmc.2016.10.020	journal	January 2017
Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors Liu, Tingting; Wan, Yichao; Liu, Renshuai Bioorganic & Medicinal Chemistry, Vol. 25, Issue 6 https://doi.org/10.1016/j.bmc.2017.02.014	journal	March 2017
Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors Liu, Renshuai; Liu, Lulu; Liu, Tingting Bioorganic & Medicinal Chemistry, Vol. 26, Issue 17 https://doi.org/10.1016/j.bmc.2018.08.030	journal	September 2018
Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design Van der Poorten, Olivier; Knuhtsen, Astrid; Sejer Pedersen, Daniel Journal of Medicinal Chemistry, Vol. 59, Issue 24 https://doi.org/10.1021/acs.jmedchem.6b01029	journal	October 2016
Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets Schoenwaelder, Simone M.; Jarman, Kate E.; Gardiner, Elizabeth E. Blood, Vol. 118, Issue 6 https://doi.org/10.1182/blood-2011-04-347849	journal	August 2011
An Improved Synthesis of (3 R )-2-( tert -Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid Liu, Cong; Thomas, James; Brieaddy, Larry Synthesis, Vol. 2008, Issue 6 https://doi.org/10.1055/s-2008-1032211	journal	March 2008
Discovery of a Tetrahydroisoquinoline-Based Hydroxamic Acid Derivative (ZYJ-34c) as Histone Deacetylase Inhibitor with Potent Oral Antitumor Activities Zhang, Yingjie; Fang, Hao; Feng, Jinhong Journal of Medicinal Chemistry, Vol. 54, Issue 15 https://doi.org/10.1021/jm200577a	journal	August 2011
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