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Title: Bringing diffuse X-ray scattering into focus

Abstract

X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.

Authors:
; ; ORCiD logo
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1633124
Alternate Identifier(s):
OSTI ID: 1422967
Report Number(s):
LA-UR-17-30486
Journal ID: ISSN 0959-440X; S0959440X1730180X; PII: S0959440X1730180X
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Published Article
Journal Name:
Current Opinion in Structural Biology
Additional Journal Information:
Journal Name: Current Opinion in Structural Biology Journal Volume: 50 Journal Issue: C; Journal ID: ISSN 0959-440X
Publisher:
Elsevier
Country of Publication:
United Kingdom
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION; Biological Science

Citation Formats

Wall, Michael E., Wolff, Alexander M., and Fraser, James S. Bringing diffuse X-ray scattering into focus. United Kingdom: N. p., 2018. Web. doi:10.1016/j.sbi.2018.01.009.
Wall, Michael E., Wolff, Alexander M., & Fraser, James S. Bringing diffuse X-ray scattering into focus. United Kingdom. doi:10.1016/j.sbi.2018.01.009.
Wall, Michael E., Wolff, Alexander M., and Fraser, James S. Fri . "Bringing diffuse X-ray scattering into focus". United Kingdom. doi:10.1016/j.sbi.2018.01.009.
@article{osti_1633124,
title = {Bringing diffuse X-ray scattering into focus},
author = {Wall, Michael E. and Wolff, Alexander M. and Fraser, James S.},
abstractNote = {X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.},
doi = {10.1016/j.sbi.2018.01.009},
journal = {Current Opinion in Structural Biology},
number = C,
volume = 50,
place = {United Kingdom},
year = {2018},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1016/j.sbi.2018.01.009

Citation Metrics:
Cited by: 2 works
Citation information provided by
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